| 1429920-41-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1429920-41-1
• 化学式: C₁₁₅H₁₃₂N₂O₂₄
• 分子量: 1926.31
• InChiKey: HNIOVYDWALKERT-YFEQVULDSA-N

反应信息

• 作为反应物：
  描述：

  在 氢气 、 palladium(II) hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 24.0h， 以5 mg的产率得到5-aminopentanyl-3,6-dideoxy-α-L-xylo-hexopyranosyl-(1→3)-3,6-dideoxy-α-L-xylo-hexopyranosyl-(1→6)-α-L-galactopyranosyl-α-D-glucopyranosyl-(1→4)-α-D-galactopyranosyl-(1→3)-2-N-acetyl-β-D-glucopyranoside
  参考文献：
  名称：

  Total Synthesis of theEscherichia coliO111O-Specific Polysaccharide Repeating Unit

  摘要：

  AbstractThe first total synthesis of the O‐antigen pentasaccharide repeating unit from Gram‐negative bacteria Escherichia coli O111 was achieved starting from four monosaccharide building blocks. Key to the synthetic approach was a bis‐glycosylation reaction to combine trisaccharide 10 and colitose 5. The colitose building block (5) was obtained de novo from non‐carbohydrate precursors. The pentasaccharide was equipped at the reducing end with an amino spacer to provide a handle for subsequent conjugation to a carrier protein in anticipation of immunological studies.

  DOI：

  10.1002/chem.201204394
• 作为产物：
  描述：

  在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Total Synthesis of theEscherichia coliO111O-Specific Polysaccharide Repeating Unit

  摘要：

  AbstractThe first total synthesis of the O‐antigen pentasaccharide repeating unit from Gram‐negative bacteria Escherichia coli O111 was achieved starting from four monosaccharide building blocks. Key to the synthetic approach was a bis‐glycosylation reaction to combine trisaccharide 10 and colitose 5. The colitose building block (5) was obtained de novo from non‐carbohydrate precursors. The pentasaccharide was equipped at the reducing end with an amino spacer to provide a handle for subsequent conjugation to a carrier protein in anticipation of immunological studies.

  DOI：

  10.1002/chem.201204394