4-(p-tolyl)nonan-5-one | 1268834-05-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-(p-tolyl)nonan-5-one
• CAS: 1268834-05-4
• 化学式: C₁₆H₂₄O
• 分子量: 232.366
• InChiKey: CHUWJTKWUFKEHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.64
• 重原子数：
  17.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  、 (pTol)₃Al 生成 4-(p-tolyl)nonan-5-one
  参考文献：
  名称：

  N-烷氧基胺的极性反转使酮的亲核性α-芳基化和α-烷基化：在羰基化合物的α-碳原子位置进入Umpolung反应

  摘要：

  烯胺化学的一个新方面：由酮形成N烷氧基烯胺导致了有效的umpolung反应。的烷基化Ñ -alkoxyenamines与三烷基铝化合物顺利进行，给α -烷基化的酮（参见方案）。该反应无需分离烯胺和中间体亚胺，即可将酮简单地转化为α-取代的酮。

  DOI：

  10.1002/anie.201004374

文献信息

• N -Heterocyclic carbene-palladium(II)-1-methylimidazole complex catalyzed α-arylation of symmetric dialkyl ketones with aryl chlorides
  作者：Zheng-Kang Xiao、Hui-Ying Yin、Jian-Mei Lu

  DOI：10.1016/j.ica.2014.07.061

  日期：2014.11

  N-Heterocyclic carbene-palladium(II)-1-methylimidazole [NHC-Pd(II)-Im] complex 1 showed efficient catalytic activity toward alpha-arylation of symmetric dialkyl ketones under mild conditions. It was found that the ratio of aryl chlorides and ketones drastically affected the reaction. When the ratio of aryl chlorides and ketones was 1:2, mono-arylated products can be obtained in good to high yields as the sole; while that of aryl chlorides and ketones was changed to 1:0.7, di- and mono-arylated products were obtained in good to high total yields at the same time, with the former as the major. (C) 2014 Elsevier B.V. All rights reserved.