4-环己基丁烷-2-酮 | 2316-85-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-环己基丁烷-2-酮
• 英文名称: 4-cyclohexyl-2-butanone
• 英文别名: 4-cyclohexylbutan-2-one
• CAS: 2316-85-0
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: IRQGFFDNBUXBLR-UHFFFAOYSA-N

物化性质

• 沸点：
  105 °C(Press: 12 Torr)
• 密度：
  0.9161 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914299000

反应信息

• 作为反应物：
  描述：

  4-环己基丁烷-2-酮 在 咪唑 、 magnesium 、 mercury dichloride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 生成 <<1-(2-Cyclohexylethyl)-1-methyl-3-butynyl>oxy>trimethylsilane
  参考文献：
  名称：

  18-Cycloalkyl analogs of enisoprost

  摘要：

  By use of standard cuprate methodology, a series of 18-cycloalkyl analogues of enisoprost was prepared in an effort to impede omega chain metabolism and prolong duration of gastric antisecretory activity. An initial product of omega chain oxidation, the C-20 hydroxy analogue, was also synthesized for pharmacological comparison. The cyclopropyl, cyclobutyl, and cyclopentyl analogues were approximately one-fourth as potent as enisoprost in inhibiting gastric acid secretion, while the cyclohexyl and cycloheptyl analogues showed very weak activity, and the 20-hydroxy compound was inactive at a dose 100 times the ED50 of enisoprost. The cyclobutyl compound had a longer duration of antisecretory action than enisoprost and the other cycloalkyl analogues. The cycloalkyl analogues unexpectedly possessed low diarrheogenic activity in rats.

  DOI：

  10.1021/jm00125a013
• 作为产物：
  描述：

  (E)-4-cyclohexylbut-3-en-2-ol 在 cis-chloromethyl[bis(dicyclohexylphosphino)ethane]palladium(II) 、 四(3,5-二(三氟甲基)苯基)硼酸钠 作用下， 以 1,2-二氯乙烷 、 环己烯 为溶剂， 反应 18.0h， 以62%的产率得到4-环己基丁烷-2-酮
  参考文献：
  名称：

  钯催化高度取代的烯丙醇、高烯丙醇和烯基醇异构化的范围和机制

  摘要：

  在此，我们报告了通过单一催化体系钯催化的高度取代的烯丙醇和链烯醇的异构化。操作简单的反应方案适用于广泛的底物，并显示出广泛的官能团耐受性，并且产物通常以高化学产率分离。实验和计算机制研究为由重复迁移插入/β-H 消除序列组成的链行走过程提供了补充和收敛的证据。有趣的是，在烯丙醇异构化过程中，催化剂不会从底物上解离，而当烷基链上存在额外的取代基时，它会在烯醇异构化过程中脱离。

  DOI：

  10.1021/ja508736u

文献信息

• Catalytic Transfer Hydrogenation of Arenes and Heteroarenes
  作者：Coralie Gelis、Arne Heusler、Zackaria Nairoukh、Frank Glorius

  DOI：10.1002/chem.202002777

  日期：2020.11.6

  Transfer hydrogenation reactions are of great interest to reduce diverse molecules under mild reaction conditions. To date, this type of reaction has only been successfully applied to alkenes, alkynes and polarized unsaturated compounds such as ketones, imines, pyridines, etc. The reduction of benzene derivatives by transfer hydrogenation has never been described, which is likely due to the high energy

  转移氢化反应对于在温和的反应条件下还原各种分子非常重要。迄今为止，这种类型的反应仅成功地用于烯烃，炔烃和极化的不饱和化合物，例如酮，亚胺，吡啶等。从未描述过通过转移氢化还原苯衍生物的方法，这很可能是由于高使这些化合物脱芳香化所需的能量屏障。在此背景下，我们开发了一种催化转移氢化反应，用于还原苯衍生物和杂芳烃，从而在不需要压缩氢气的情况下，在室温下形成带有各种官能团的复杂三维支架。
• COMPOUNDS HAVING A POTENTIATING EFFECT ON THE ACTIVITY OF ETHIONAMIDE AND USES THEREOF
  申请人：Deprez Benôit

  公开号：US20110136823A1

  公开（公告）日：2011-06-09

  The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.

  本发明涉及具有增强抗生素活性的化合物，这些抗生素通过EthA酶途径可激活，用于制备预防和/或治疗如结核病和麻风病等分枝杆菌感染的药物；涉及包含这些化合物与通过EthA途径可激活的抗生素组合的药物组合物；涉及具有增强通过EthA酶途径可激活抗生素活性的化合物；涉及包含这些化合物的药物组合物；以及涉及它们作为药物，特别是用于预防和/或治疗如结核病和麻风病等分枝杆菌感染的药物的使用。
• Iridium-Catalyzed Alkene-Selective Transfer Hydrogenation with 1,4-Dioxane as Hydrogen Donor
  作者：Deliang Zhang、Tomohiro Iwai、Masaya Sawamura

  DOI：10.1021/acs.orglett.9b01989

  日期：2019.8.2

  using 1,4-dioxane as a hydrogen donor is described. The use of 1,2-bis(dicyclohexylphosphino)ethane (DCyPE), featuring bulky and highly electron-donating properties, led to high catalytic activity. A polystyrene-cross-linking bisphosphine PS-DPPBz produced a reusable heterogeneous catalyst. These homogeneous and heterogeneous protocols achieved chemoselective transfer hydrogenation of alkenes over

  描述了使用1，4-二恶烷作为氢供体的铱催化的烯烃的转移加氢。1,2-双（二环己基膦基）乙烷（DCyPE）的使用具有体积大和给电子高的特性，因此具有很高的催化活性。聚苯乙烯交联双膦PS-DPPBz产生了可重复使用的非均相催化剂。这些均质和非均质的方案实现了烯烃在其他可能还原的官能团（例如同一分子中的羰基，硝基，氰基和亚氨基）上的化学选择性转移加氢。
• Rhodium–nickel bimetallic nanocatalysts: high performance of room-temperature hydrogenation
  作者：Haohong Duan、Dingsheng Wang、Yuan Kou、Yadong Li

  DOI：10.1039/c2cc37668g

  日期：——

  Rhodium–nickel bimetallic nanocrystals were fabricated with high activity in hydrogenation of olefins, nitroarenes and arenes at room temperature, indicating that bimetallic nanocrystals of noble and non-noble metals represent a novel kind of nanocatalyst.

  铑-镍双金属纳米晶体在室温下表现出对烯烃、硝基芳烃和芳烃加氢反应的高活性，表明贵金属与非贵金属组成的双金属纳米晶体代表了一类新型的纳米催化剂。
• Bimetallic Nanoparticles in Supported Ionic Liquid Phases as Multifunctional Catalysts for the Selective Hydrodeoxygenation of Aromatic Substrates
  作者：Lisa Offner-Marko、Alexis Bordet、Gilles Moos、Simon Tricard、Simon Rengshausen、Bruno Chaudret、Kylie L. Luska、Walter Leitner

  DOI：10.1002/anie.201806638

  日期：2018.9.24

  Bimetallic iron–ruthenium nanoparticles embedded in an acidic supported ionic liquid phase (FeRu@SILP+IL‐SO3H) act as multifunctional catalysts for the selective hydrodeoxygenation of carbonyl groups in aromatic substrates. The catalyst material is assembled systematically from molecular components to combine the acid and metal sites that allow hydrogenolysis of the C=O bonds without hydrogenation

  嵌入酸性负载型离子液相（FeRu @ SILP + IL-SO 3 H）中的双金属铁-钌纳米粒子可作为多功能催化剂，用于芳香族基质中羰基的选择性加氢脱氧。催化剂材料由分子组分系统地组装，以结合酸和金属位点，从而允许C = O键的氢解而无需芳族环的氢化。所得材料对各种取代的芳族酮中的C = O基团催化加氢脱氧为CH 2单元具有很高的活性和稳定性，因此，它是传统的Clemmensen和Wolff-Kishner还原反应的理想替代品，而该方法需要化学计量比试剂。FeRu @ SILP + IL‐SO的分子设计3 H材料为多功能催化系统（MM'@ SILP + IL-func）开辟了通用途径。