Acetic acid (1R,2R,3S,4S,6R,7R,8S,14R)-6-hydroxy-2,4,7,14-tetramethyl-9,12-dioxo-4-vinyl-tricyclo[5.4.3.0^1,8]tetradec-3-yl ester | 569657-84-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Acetic acid (1R,2R,3S,4S,6R,7R,8S,14R)-6-hydroxy-2,4,7,14-tetramethyl-9,12-dioxo-4-vinyl-tricyclo[5.4.3.0^1,8]tetradec-3-yl ester
• CAS: 569657-84-7
• 化学式: C₂₂H₃₂O₅
• 分子量: 376.493
• InChiKey: VVUMMPYWDZWXRP-ZGOXWQKVSA-N

反应信息

• 作为反应物：
  描述：

  Acetic acid (1R,2R,3S,4S,6R,7R,8S,14R)-6-hydroxy-2,4,7,14-tetramethyl-9,12-dioxo-4-vinyl-tricyclo[5.4.3.0^1,8]tetradec-3-yl ester 在 sodium hydroxide 、 N,N-二异丙基乙胺 作用下， 以 氯仿 为溶剂， 生成 (4-Methoxy-phenyl)-carbamic acid (1R,2R,3S,4S,6R,7R,8S,14R)-3-hydroxy-2,4,7,14-tetramethyl-9,12-dioxo-4-vinyl-tricyclo[5.4.3.0^1,8]tetradec-6-yl ester
  参考文献：
  名称：

  Synthesis and activity of a C-8 keto pleuromutilin derivative

  摘要：

  A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00297-x
• 作为产物：
  描述：

  8-hydroxymutilin 在 吡啶 、 N-甲基吲哚酮 、 四丙基高钌酸铵 、 4 A molecular sieve 、 2,4-滴二甲胺盐 作用下， 以 乙腈 为溶剂， 生成 Acetic acid (1R,2R,3S,4S,6R,7R,8S,14R)-6-hydroxy-2,4,7,14-tetramethyl-9,12-dioxo-4-vinyl-tricyclo[5.4.3.0^1,8]tetradec-3-yl ester
  参考文献：
  名称：

  Synthesis and activity of a C-8 keto pleuromutilin derivative

  摘要：

  A C-8 keto pleuromutilin derivative has been synthesized from the biotransformation product 8-hydroxy mutilin. A key step in the process was the selective oxidation at C-8 of 8-hydroxy mutilin using tetrapropylammonium perruthenate. The presence of the C-8 keto group precipitated interesting intramolecular chemistry to afford a compound (10) with a novel pleuromutilin-derived ring system. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00297-x