[(3R,4R,5R,6R)-4,5-diacetyloxy-6-(2-methyl-4-oxo-3-phenylmethoxypyridin-1-yl)oxan-3-yl] acetate | 174355-18-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(3R,4R,5R,6R)-4,5-diacetyloxy-6-(2-methyl-4-oxo-3-phenylmethoxypyridin-1-yl)oxan-3-yl] acetate
• CAS: 174355-18-1
• 化学式: C₂₄H₂₇NO₉
• 分子量: 473.48
• InChiKey: WKOULNHUGYQXPH-MSNJVRRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  [(3R,4R,5R,6R)-4,5-diacetyloxy-6-(2-methyl-4-oxo-3-phenylmethoxypyridin-1-yl)oxan-3-yl] acetate 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 水 、 溶剂黄146 为溶剂， 生成 Acetic acid (2R,3R,4R,5R)-4,5-diacetoxy-2-(3-hydroxy-2-methyl-4-oxo-4H-pyridin-1-yl)-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Synthesis of 2-Alkyl-3-hydroxy-4-pyridinone-ribonucleosides, Potential Oral Iron Chelators

  摘要：

  Several ribonucleosides, named 2-alkyl-3-hydroxy-1-(beta-D-ribofuranosyl or pyranosyl)-4-pyridinones, were synthesized in good yield. The method provides a useful means to obtain alpha-ketohydroxypyridin derivatives with different sugar moieties that, if used as drugs, might enhance their absorption from the intestine and certain other desirable pharmacological properties.

  DOI：

  10.1080/15257779508010712
• 作为产物：
  描述：

  3-苄氧基-2-甲基-4(1H)-吡啶酮 在 三甲基氯硅烷 、 四氯化锡 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 6.0h， 生成 [(3R,4R,5R,6R)-4,5-diacetyloxy-6-(2-methyl-4-oxo-3-phenylmethoxypyridin-1-yl)oxan-3-yl] acetate
  参考文献：
  名称：

  Synthesis of 2-Alkyl-3-hydroxy-4-pyridinone-ribonucleosides, Potential Oral Iron Chelators

  摘要：

  Several ribonucleosides, named 2-alkyl-3-hydroxy-1-(beta-D-ribofuranosyl or pyranosyl)-4-pyridinones, were synthesized in good yield. The method provides a useful means to obtain alpha-ketohydroxypyridin derivatives with different sugar moieties that, if used as drugs, might enhance their absorption from the intestine and certain other desirable pharmacological properties.

  DOI：

  10.1080/15257779508010712