3'-phenylpropiophenone | 107075-99-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3'-phenylpropiophenone
• 英文别名: 4'-phenylpropiophenone；1-(3-Phenylphenyl)propan-1-one
• CAS: 107075-99-0
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: UWSZEAAIPZTRHC-UHFFFAOYSA-N

物化性质

• 熔点：
  89 °C
• 沸点：
  344 °C
• 密度：
  1.037±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-甲基噻吩 、 3'-phenylpropiophenone 在 silver carbonate 、 2,2,6,6-四甲基哌啶氧化物 、 lithium acetate 、 palladium diacetate 、 三环己基膦 作用下， 以 乙二醇二甲醚 为溶剂， 反应 24.0h， 以83%的产率得到(E)-1-(biphenyl-3-yl)-3-(5-methylthiophen-2-yl)prop-2-en-1-one
  参考文献：
  名称：

  使用饱和酮作为烯烃源，钯催化（杂）芳烃的CH卤化

  摘要：

  耐受性：通过使用Pd（OAc）2 / PCy 3作为催化剂，富含电子的芳族杂环和缺乏电子的氟苯都可以与（杂）芳基乙基酮进行脱氢交叉偶联，收率很高。宽泛的官能团是可以容忍的，因此提供了一种轻松合成查耳酮或杂环查耳酮类似物的通用方法。此外，二烷基酮也可以参与该转化。

  DOI：

  10.1002/anie.201208627
• 作为产物：
  描述：

  1-([1,1'-biphenyl]-3-yl)propan-1-ol 在 chromium(VI) oxide 、 硫酸 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 3'-phenylpropiophenone
  参考文献：
  名称：

  Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

  摘要：

  Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series, 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.

  DOI：

  10.1016/0223-5234(96)88213-4

文献信息

• ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF
  申请人：AMARI Gabriele

  公开号：US20110311458A1

  公开（公告）日：2011-12-22

  The present invention relates to alkaloid aminoester compounds which act as muscarinic receptor antagonists, processes for their preparation, compositions comprising them, and therapeutic uses thereof.

  本发明涉及作为毒蕈碱受体拮抗剂的生物碱氨基酸酯化合物、它们的制备方法、包含它们的组合物及其治疗用途。
• An efficient class of bis-NHC salts: applications in Pd-catalyzed reactions under mild reaction conditions
  作者：Chien-Cheng Chiu、Hui-Tzu Chiu、Dong-Sheng Lee、Ta-Jung Lu

  DOI：10.1039/c8ra04094j

  日期：——

  (bis-NHC) salts that can be easily made from commercially available and inexpensive starting materials. The application of these salts to Pd-catalyzed reactions is described. The palladium (Pd) catalyst generated in situ was highly effective under mild reaction conditions.

  这项研究描述了一类有效的双-N-杂环卡宾 (bis-NHC) 盐，可以很容易地由市售且廉价的起始材料制成。描述了这些盐在 Pd 催化反应中的应用。原位生成的钯 (Pd) 催化剂在温和的反应条件下非常有效。
• METHOD FOR PRODUCING CYCLOHEXYL ALKYL KETONES
  申请人：Nishiuchi Junya

  公开号：US20120178970A1

  公开（公告）日：2012-07-12

  Provided is an industrially superior method for producing cyclohexyl alkyl ketones, which solves the problems in process reduction and in disposal of wastes such as metals. An aromatic ketone represented by a formula (1) is nuclear-hydrogenated with pressurized hydrogen and in the presence of a solvent at a temperature of from 20 to 120° C., in the presence of a catalyst that carries from 0.1 to 20% by weight of a ruthenium atom on the carrier, thereby producing a cyclohexyl alkyl ketone represented by a formula (2): provided that, in the formula (2), n indicates an integer of from 1 to 3; R represents a hydroxyl group, a cyclohexyl group, an alkyl group having from 1 to 4 carbon atoms, or an acyl group having from 1 to 4 carbon atoms

  提供了一种在工业上优越的生产环己基烷基酮的方法，解决了在过程减少和处理废物（如金属）方面的问题。通过在20至120°C的温度下，在有溶剂存在的情况下使用加压氢气进行核氢化，存在携带从0.1到20%重量的钌原子的催化剂，从而产生一个由式（2）表示的环己基烷基酮：其中，在式（2）中，n表示1到3之间的整数；R代表一个羟基、一个环己基、一个含有1至4个碳原子的烷基或一个含有1至4个碳原子的酰基。
• Ligand-free Suzuki coupling reaction with highly recyclable ionic palladium catalyst, Ti1-xPdxO2-x (x = 0.03)
  作者：Shrikanth Bhat K、Veeranjaneyulu Lanke、Jagadeesh Dasappa Prasad、Kandikere Ramaiah Prabhu

  DOI：10.1016/j.apcata.2020.117516

  日期：2020.4

  We synthesized a recyclable palladium ionic catalyst, Ti0.97Pd0.03O1.97, using a solution combustion method (SCM), and characterized by XRD and Rietveld refinement. The synthesized Pd ionic catalyst is stable, insensitive to moisture and air, and easy to handle. The new catalyst has exhibited a phenomenal result for the Suzuki-Miyaura cross-coupling reaction with a broad substrate scope, and the reaction

  我们使用溶液燃烧法（SCM）合成了可回收的钯离子催化剂Ti 0.97 Pd 0.03 O 1.97，并通过XRD和Rietveld精炼进行了表征。合成的Pd离子催化剂稳定，对湿气和空气不敏感并且易于处理。新型催化剂对于具有宽底物范围的Suzuki-Miyaura交叉偶联反应显示出了惊人的结果，并且该反应在水性介质中进行。不管反应中使用的芳基卤化物（富电子或贫电子或杂环化合物）如何，新催化剂都被证明是有益的，并且产生了优异的收率，并且不同反应的周转频率（TOF）为14–25 h -1。将该催化剂涂覆在堇青石整体料（Mg2 Al 4 Si 5 O 18），提高了催化剂的适用性，并使催化剂的处理和回收非常容易。Suzuki Miyaura反应使用Pd粉体催化剂和Pd涂层蜂窝体进行，结果几乎相似。我们已经证明了Pd包覆堇青石整料的可回收性，并显示了Suzuki-Miyaura反应的催化剂优于其他Pd催化剂。
• Thiophenes useful in control of acarids
  申请人：Uniroyal, Inc.

  公开号：US04174405A1

  公开（公告）日：1979-11-13

  Substituted thiophenes of the following formula, some of which are new compounds, are useful in controlling certain pests, particularly mites: ##STR1## wherein A, Y and Z are various substituents such as phenyl and substituted phenyl.

  以下化学式中的取代噻吩，其中一些是新化合物，可用于控制某些害虫，特别是螨虫：##STR1## 其中A、Y和Z是各种取代基，如苯基和取代苯基。