纳洛酮EP杂质E | 26451-92-3

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 中文名称: 纳洛酮EP杂质E
• 英文名称: 7,8-Didehydro Naloxone
• 英文别名: (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
• CAS: 26451-92-3
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.4
• InChiKey: VHFYKBURRFNDQL-GRGSLBFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  70
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] REDUCTION OF ALPHA, BETA-UNSATURATED KETONE LEVELS IN MORPHINAN DERIVATIVE COMPOSITIONS<br/>[FR] RÉDUCTION DES NIVEAUX DE CÉTONE ALPHA, BETA-INSATURÉE DANS DES COMPOSITIONS DE DÉRIVÉS DE MORPHINANE
  申请人：RHODES TECHNOLOGIES

  公开号：WO2016005923A1

  公开（公告）日：2016-01-14

  The disclosure relates to processes for reducing the amount of a compound of formula (I) or a salt or a solvate thereof present in a composition comprising compounds of formulae (I) and (II) or a salt or a solvate thereof.

  本公开涉及减少式(I)化合物或其盐或溶剂合物在包含式(I)和(II)化合物或其盐或溶剂合物的组合物中的数量的方法。
• [EN] PROCESS FOR THE PREPARATION OF MORPHINAN-6-ONE COMPOUNDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS MORPHINAN-6-ONES
  申请人：JOHNSON MATTHEY PLC

  公开号：WO2015015147A1

  公开（公告）日：2015-02-05

  The present provides a process for preparing a compound of formula (3), the process comprising the steps of: (a) providing an aqueous acidic solution comprising a compound of formula (1) and, as an impurity, a compound of formula (2); and (b) treating the aqueous acidic solution of step (a) such that the compound of formula (2) dehydrates to form a compound of formula (1) and the compound of formula (1) is reduced to form an aqueous acidic solution of the compound of formula (3), wherein: the treating of step (b) is carried out at one or more temperatures greater than ambient in the presence of a hydrogenation catalyst and hydrogen gas; and wherein for the compounds of formulae (1), (2) and (3): i) R1 is -OH, R2 is-OH and R3-H; or ii) R1 is -OCH3, R2 is -H and R3 -CH3; or iii) R1 is-OH, R2 is-H and R3-CH3; or iv) R1, is -OCH3, R2 is -H and R3 -H; or v) R1, is -OH, R2is-H and R3-H; or vi) R1, is -OCH3, R2 is -OH and R3 -H.

  本发明提供了一种制备式（3）化合物的方法，该方法包括以下步骤：（a）提供含有式（1）化合物和式（2）化合物作为杂质的水酸性溶液；和（b）处理步骤（a）中的水酸性溶液，使得式（2）化合物脱水形成式（1）化合物，而式（1）化合物还原形成含有式（3）化合物的水酸性溶液，其中：步骤（b）的处理在氢化催化剂和氢气的存在下，在一个或多个高于环境温度的温度下进行；对于式（1）、（2）和（3）化合物：i）R1为-OH，R2为-OH，R3为H；或ii）R1为-OCH3，R2为H，R3为CH3；或iii）R1为-OH，R2为H，R3为CH3；或iv）R1为-OCH3，R2为H，R3为H；或v）R1为-OH，R2为H，R3为H；或vi）R1为-OCH3，R2为-OH，R3为H。
• PROCESS FOR THE PREPARATION OF MORPHINAN-6-ONE COMPOUNDS
  申请人：JOHNSON MATTHEY PUBLIC LIMITED COMPANY

  公开号：US20160176887A1

  公开（公告）日：2016-06-23

  A process for preparing a compound of formula (3), includes the steps of: (a) providing an aqueous acidic solution including a compound of formula (1) and, as an impurity, a compound of formula (2); and (b) treating the aqueous acidic solution of step (a) such that the compound of formula (2) dehydrates to form a compound of formula (1) which is reduced to form an aqueous acidic solution of the compound of formula (3), the treating step (b) being carried out at one or more temperatures greater than ambient in the presence of a hydrogenation catalyst and hydrogen gas; and wherein for the compounds of formulae (1), (2) and (3): i) R 1 is —OH, R 2 is —OH and R 3 —H; or ii) R 1 is —OCH 3 , R 2 is —H and R 3 —CH 3 ; or iii) R 1 is —OH, R 2 is —H and R 3 —CH 3 ; or iv) R 1 is —OCH 3 , R 2 is —H and R 3 —H; or v) R 1 is —OH, R 2 is —H and R 3 —H; or vi) R 1 is —OCH 3 , R 2 is —OH and R 3 —H.
• REDUCTION OF ALPHA, BETA-UNSATURATED KETONE LEVELS IN MORPHINAN DERIVATIVE COMPOSITIONS
  申请人：Rhodes Technologies

  公开号：US20170342084A1

  公开（公告）日：2017-11-30

  The disclosure relates to processes for reducing the amount of a compound of formula (I) or a salt or a solvate thereof present in a composition comprising compounds of formulae (I) and (II) or a salt or a solvate thereof.
• US9908891B2
  申请人：——

  公开号：US9908891B2

  公开（公告）日：2018-03-06