4-甲基香豆素基-Β-L-吡喃岩藻糖苷 | 72601-82-2

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 4-甲基香豆素基-Β-L-吡喃岩藻糖苷
• 中文别名: 4-甲基伞形酮-beta-L-吡喃岩藻糖苷
• 英文名称: 4-methylumbelliferyl-β-L-fucopyranoside
• 英文别名: 4-Methylumbelliferyl beta-L-fucopyranoside；4-methyl-7-[(2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-2-one
• CAS: 72601-82-2
• 化学式: C₁₆H₁₈O₇
• mdl: MFCD00067660
• 分子量: 322.315
• InChiKey: CQKHENXHLAUMBH-NXPHAWEXSA-N

物化性质

• 熔点：
  233 - 238°C
• 沸点：
  565.9±50.0 °C(Predicted)
• 密度：
  1.441±0.06 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.437
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

安全信息

• WGK Germany：
  3
• 海关编码：
  29400090

反应信息

• 作为产物：
  描述：

  2,3,4-三-O-乙酰基-6-脱氧-alpha-L-溴代半乳糖 在 甲醇 、 sodium hydroxide 、 sodium methylate 、 四丁基硫酸氢铵 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 4-甲基香豆素基-Β-L-吡喃岩藻糖苷
  参考文献：
  名称：

  Profiling of Glycosidase Activities Using Coumarin-Conjugated Glycoside Cocktails

  摘要：

  Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.

  DOI：

  10.1021/ol062889f

文献信息

• Methods and device for detection of microorganisms
  申请人：BioControl Systems, Inc.

  公开号：EP0264221A2

  公开（公告）日：1988-04-20

  A device adapted for containing a volume of growth medium and employed for detection of gas produced by a micro­organism or microorganisms putatively contained within a test sample and added to the growth medium, comprising a primary chamber, a dome defined by the top surface of the primary chamber and communicating therewith, the dome establishing a fluid level and adapted for collection of gas produced by a microorganism within the growth medium, and a fill section adja­cent to and communicating with one end of the primary chamber, the fill section spaced apart from the dome and extending above the fluid level, and further defining an opening for the addi­tion of a test sample is disclosed. The device may be sealed by means of a removable closure. An apparatus consisting of an array of substantially identical devices is also disclosed. In addition, methods of using the device and apparatus for detect­ing and estimating numbers of microorganisms, and for analyzing samples putatively containing a microorganism, are disclosed.

  一种装置，适于容纳一定体积的生长培养基，并用于检测由假定包含在测试样品中并被添加到生长培养基中的一种或多种微生物产生的气体，该装置包括一个主腔室、一个由主腔室顶面限定并与之相通的穹顶、该装置包括主室、一个由主室顶面限定并与之相通的圆顶，圆顶确定一个液面并适于收集生长培养基中微生物产生的气体，以及一个与主室一端相邻并相通的填充部分，填充部分与圆顶间隔开并延伸到液面之上，并进一步确定一个用于添加测试样品的开口。该装置可通过一个可拆卸的封闭装置进行密封。还公开了一种由基本相同的装置阵列组成的装置。此外，还公开了使用该装置和设备检测和估计微生物数量以及分析假定含有微生物的样品的方法。
• Biological indicator
  申请人：American Sterilizer Company

  公开号：US10011843B2

  公开（公告）日：2018-07-03

  This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.

  本发明涉及一种生物指示剂，其成分包括：由形成孢子的细菌组成的宿主生物；产生指示剂酶的报告基因；调控基因；以及将报告基因和调控基因插入宿主生物的载体；宿主生物的基因组中含有转座遗传因子，用于在调控基因中插入插入序列；插入序列包括转座酶、一对末端倒置重复序列和至少一个用于表达转座酶的开放阅读框。载体可被宿主生物吸收。插入序列可插入调控基因中。宿主生物可进行孢子繁殖以形成生物指示剂。本发明公开了一种使用生物指示剂的工艺和装置。
• Compositions and methods for detecting proteinopathies
  申请人：BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

  公开号：US10962553B2

  公开（公告）日：2021-03-30

  This invention is directed to compositions and methods for detecting proteinopathies.

  本发明涉及检测蛋白质病的组合物和方法。
• METHOD AND COMPOSITION FOR DETECTING BACTERIAL CONTAMINATION IN FOOD PRODUCTS
  申请人：BioControl Systems, Inc.

  公开号：EP0870054B1

  公开（公告）日：2008-07-30
• GENETICALLY ENGINEERED BIOLOGICAL INDICATOR
  申请人：American Sterilizer Company

  公开号：EP2084293B1

  公开（公告）日：2014-08-13