4-N-pivaloyl-2'-O-(9-phenylxanthen-9-yl)-5'-O-(tert-butoxydiphenylsilyl)adenosine | 195247-47-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 4-N-pivaloyl-2'-O-(9-phenylxanthen-9-yl)-5'-O-(tert-butoxydiphenylsilyl)adenosine
• CAS: 195247-47-3
• 化学式: C₅₀H₅₁N₅O₇Si
• 分子量: 862.07
• InChiKey: APSUKIGZLKOUFV-QQJAHVSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.64
• 重原子数：
  63.0
• 可旋转键数：
  11.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  139.08
• 氢给体数：
  2.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  乙酰丙酸酐 、 4-N-pivaloyl-2'-O-(9-phenylxanthen-9-yl)-5'-O-(tert-butoxydiphenylsilyl)adenosine 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 、 三乙胺 为溶剂， 以81%的产率得到4-N-pivaloyl-2'-O-(9-phenylxanthen-9-yl)-3'-O-laevulinyl-5'-O-(tert-butoxydiphenylsilyl)adenosine
  参考文献：
  名称：

  Solid-phase synthesis of branched RNA and branched DNA/RNA chimeras

  摘要：

  An effective method for synthesising branched oligonucleotides on solid phase in the 5' to 3' direction has been developed. Special branch-point monomers enable the synthesis of branched oligonucleotides which can have sequences of different length and base composition attached to the 2'-and 3'-hydroxyl groups of the branch point ribonucleoside. The branched oligonucleotides are assembled on commercial DNA synthesisers, the crude products are readily purified by reversed phase HPLC and the fully deprotected products are conveniently analysed by mass spectrometry. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00731-x
• 作为产物：
  描述：

  2,2-Dimethyl-N-{9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(9-phenyl-9H-xanthen-9-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-propionamide 在 咪唑 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.25h， 生成 4-N-pivaloyl-2'-O-(9-phenylxanthen-9-yl)-5'-O-(tert-butoxydiphenylsilyl)adenosine
  参考文献：
  名称：

  Solid-phase synthesis of branched RNA and branched DNA/RNA chimeras

  摘要：

  An effective method for synthesising branched oligonucleotides on solid phase in the 5' to 3' direction has been developed. Special branch-point monomers enable the synthesis of branched oligonucleotides which can have sequences of different length and base composition attached to the 2'-and 3'-hydroxyl groups of the branch point ribonucleoside. The branched oligonucleotides are assembled on commercial DNA synthesisers, the crude products are readily purified by reversed phase HPLC and the fully deprotected products are conveniently analysed by mass spectrometry. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00731-x

文献信息

• Groetli, Morten; Sproat, Brian S., Journal of the Chemical Society. Chemical communications, 1995, # 4, p. 495 - 498
  作者：Groetli, Morten、Sproat, Brian S.

  DOI：——

  日期：——