4-(3-aminopropylamino)-1H-quinolin-2-one | 913253-72-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(3-aminopropylamino)-1H-quinolin-2-one
• CAS: 913253-72-2
• 化学式: C₁₂H₁₅N₃O
• 分子量: 217.271
• InChiKey: PSSPZTAVJFFOHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-aminopropylamino)-1H-quinolin-2-one 、 3,4-二氯苯甲醛 在 sodium methylate 、 溶剂黄146 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 7.0h， 以60%的产率得到4-[3-[(3,4-dichlorophenyl)methylamino]propylamino]-1H-quinolin-2-one
  参考文献：
  名称：

  Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

  摘要：

  Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E faecium. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.062
• 作为产物：
  描述：

  2,4-二氯喹啉 在 15-冠醚-5 、 sodium hydride 作用下， 反应 48.0h， 生成 4-(3-aminopropylamino)-1H-quinolin-2-one
  参考文献：
  名称：

  Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

  摘要：

  Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E faecium. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.062