细菌萜醇 | 12777-41-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 细菌萜醇
• 英文名称: 3,7,11,15,19,23,27,31,35,39,43-undecamethyl-6,10,14,18,22,26,30,34,38,42-tetratetracontadecaen-1-ol
• 英文别名: Bactoprenol；(6E,10E,14E,18E,22E,26E,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-6,10,14,18,22,26,30,34,38,42-decaen-1-ol
• CAS: 12777-41-2
• 化学式: C₅₅H₉₂O
• 分子量: 769.335
• InChiKey: BNAIICFZMLQZKW-CYAIWNQHSA-N

物化性质

• 沸点：
  775.7±29.0 °C(Predicted)
• 密度：
  0.885±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  19.9
• 重原子数：
  56
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] INHIBITING HYDROCARBON HYDRATE AGGLOMERATION<br/>[FR] INHIBITION DE L'AGGLOMÉRATION D'HYDRATES D'HYDROCARBURES
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2018218281A1

  公开（公告）日：2018-12-06

  A process for inhibiting the formation of gas hydrates in a hydrocarbon fluid comprising adding to the hydrocarbon fluid, a gas hydrate anti-agglomerate which is a biodegradable anti-agglomerant derived from a naturally occurring substance.

  一种抑制碳氢化合物流体中天然气水合物形成的方法包括向碳氢化合物流体中添加一种气体水合物抗凝聚剂，该抗凝聚剂是一种可生物降解的抗凝聚剂，来源于天然存在的物质。
• Penetrating topical pharmaceutical compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0043738A2

  公开（公告）日：1982-01-13

  A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C3-C4 diol, diol ester, or diol ether and (2) a cell envelopedisordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.

  通过将一大类亲油性药理活性化合物置于一种二元渗透增强载体中进行局部涂抹，可以有效地在完整皮肤上传递这些化合物，该载体包含（1）C3-C4 二醇、二醇酯或二醇醚和（2）细胞包膜异序化合物。与单独使用其中任何一种成分相比，这种载体能惊人地增强药理活性成分的皮肤渗透性。
• Penetrating topical pharmaceutical compositions containing 9-(2-hydroxyethoxymethyl) guanine
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0095813A2

  公开（公告）日：1983-12-07

  A group of hydrophilic substituted purine antivirals, especially 9-(2-hydroxyethoxymethyl) guanine, can be effectively delivered across skin by incorporating the selected antiviral into a binary, penetration-enhancing vehicle containing (1) a C3-C, diol, diol ester or diol ether, and (2) a cell-envelope disordering compound. These compositions provide surprising enhancement of delivery for the antivirals when compared to existing vehicles or systems, and provide a method of treating viral infections. They are especially effective as antiherpetics.

  通过将所选的抗病毒药物加入一种二元渗透增强载体中，该载体包含（1）C3-C、二元醇、二元醇酯或二元醇醚，以及（2）细胞包膜紊乱化合物，一组亲水性取代嘌呤抗病毒药物，特别是 9-（2-羟乙氧甲基）鸟嘌呤，可以有效地通过皮肤递送。与现有的载体或系统相比，这些组合物令人惊讶地增强了抗病毒药物的递送，并提供了一种治疗病毒感染的方法。它们作为抗病毒药尤其有效。
• GERANYL DIPHOSPHATE SYNTHASE GENES
  申请人：TOYOTA JIDOSHA KABUSHIKI KAISHA

  公开号：EP0974661A1

  公开（公告）日：2000-01-26

  Geranyl diphosphate synthases having an amino acid sequence derived from the amino acid sequence of farnesyl diphosphate synthase by the substitution of the amino acid at the 82-position by another amino acid having a molecular weight larger than that of Ser. More particularly, the following recombinant proteins (a) and (b) and genes encoding the same: (a) a protein having the amino acid sequence represented by SEQ ID NO:1; and (b) a protein having an amino acid sequence derived from the one represented by SEQ ID NO:1 by deletion, substitution or addition of at least one amino acid other than the one at the 82-position and exhibiting a geranyl diphosphate synthase activity.

  二磷酸香叶酯合成酶，其氨基酸序列来源于二磷酸法呢酯合成酶的氨基酸序列，方法是将 82 位的氨基酸用分子量大于 Ser 的另一种氨基酸取代。更具体地说，下列重组蛋白质(a)和(b)以及编码它们的基因：(a)具有 SEQ ID NO:1 所代表的氨基酸序列的蛋白质；和(b)具有从 SEQ ID NO:1 所代表的氨基酸序列通过删除、替换或添加除 82 位氨基酸以外的至少一个氨基酸而衍生的氨基酸序列并显示出香叶酯二磷酸合酶活性的蛋白质。
• Method for preparing lipid II and use of the lipid II thus obtained
  申请人：Universiteit Utrecht Holding B.V.

  公开号：EP1275731A1

  公开（公告）日：2003-01-15

  The present invention relates to a method for preparing Lipid II, which method comprises the steps of preparing a mixture of bacterial membranes, uridine diphosphate N-acetylmuramyl peptide (UDP-MurNAc), uridine diphosphate N-acetylglucosamine (GlcNAc), a chain of n prenyl residues, wherein n is at least 2, and optionally a detergent in a buffer; reacting the mixture thus obtained to prepare an n-Lipid II containing mixture, wherein n represents the amount of prenyl residues in the Lipid II molecule and wherein n is at least 2; and optionally further purifying the n-Lipid II containing mixture. Preferably n is selected from the range 2-25. Instead of bacterial membranes the reaction mixture may comprise isolated enzymes, such as MraY (undecaprenyl phosphate phospho-N-acetylmuramoyl-pentapeptide transferase).

  本发明涉及一种制备脂质 II 的方法，该方法包括以下步骤：在缓冲液中制备细菌膜、二磷酸尿苷 N-乙酰氨酰肽（UDP-MurNAc）、二磷酸尿苷 N-乙酰葡糖胺（GlcNAc）、n 个炔基残基链（其中 n 至少为 2）和去垢剂的混合物；将由此得到的混合物进行反应，制备含有 n-脂质 II 的混合物，其中 n 代表脂质 II 分子中炔基残基的数量，其中 n 至少为 2；并可选择进一步纯化含有 n-脂质 II 的混合物。n 最好选自 2-25 的范围。反应混合物中可以不包含细菌膜，而是包含分离出来的酶，如 MraY（十一烯丙基磷酸磷酸-N-乙酰基木酰基五肽转移酶）。