(3aR,5R,6S,7S,7aR)-7-hydroxy-5-(hydroxymethyl)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,3a,5,6,7,7a-hexahydropyrano[2,3-d][1,3]oxazol-2-one | 884525-64-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5R,6S,7S,7aR)-7-hydroxy-5-(hydroxymethyl)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,3a,5,6,7,7a-hexahydropyrano[2,3-d][1,3]oxazol-2-one
• CAS: 884525-64-8
• 化学式: C₁₃H₂₁NO₁₁
• 分子量: 367.31
• InChiKey: OAQBBQSGVLUIMT-FIYDWFNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  187
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  (3aR,5R,6S,7S,7aR)-7-hydroxy-5-(hydroxymethyl)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,3a,5,6,7,7a-hexahydropyrano[2,3-d][1,3]oxazol-2-one 、 1-((2R,3S,4R,5R,6R)-5-Amino-3,4-dihydroxy-6-phenoxy-tetrahydro-pyran-2-ylmethyl)-3-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-hydroxymethyl-5-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yl]-urea 以 水 为溶剂， 反应 24.0h， 以87 mg的产率得到1-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-3-[[(2R,3S,4R,5R,6R)-5-[[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]carbamoylamino]-3,4-dihydroxy-6-phenoxyoxan-2-yl]methyl]urea
  参考文献：
  名称：

  Synthesis of Urea-Tethered Neoglycoconjugates and Pseudooligosaccharides in Water

  摘要：

  A novel approach to the synthesis of urea glycosides in aqueous media has been explored. Steyermark's glucopyranosyl oxazolidinone was found to be a good synthon for anchoring glucosyl moieties onto amines and thiols. The present method was successfully applied to establish a new route for the synthesis of urea-tethered neoglycoconjugates and pseudooligosaccharides in water.

  DOI：

  10.1021/ja056253f
• 作为产物：
  描述：

  4-O-BETA-D-吡喃葡萄糖基-BETA-D-吡喃葡萄糖基叠氮化物 、 二氧化碳 在 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 以73%的产率得到(3aR,5R,6S,7S,7aR)-7-hydroxy-5-(hydroxymethyl)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,3a,5,6,7,7a-hexahydropyrano[2,3-d][1,3]oxazol-2-one
  参考文献：
  名称：

  Synthesis of Urea-Tethered Neoglycoconjugates and Pseudooligosaccharides in Water

  摘要：

  A novel approach to the synthesis of urea glycosides in aqueous media has been explored. Steyermark's glucopyranosyl oxazolidinone was found to be a good synthon for anchoring glucosyl moieties onto amines and thiols. The present method was successfully applied to establish a new route for the synthesis of urea-tethered neoglycoconjugates and pseudooligosaccharides in water.

  DOI：

  10.1021/ja056253f

文献信息

• Synthesis of Urea-Tethered Neoglycoconjugates and Pseudooligosaccharides in Water
  作者：Yoshiyasu Ichikawa、Yohei Matsukawa、Minoru Isobe

  DOI：10.1021/ja056253f

  日期：2006.3.1

  A novel approach to the synthesis of urea glycosides in aqueous media has been explored. Steyermark's glucopyranosyl oxazolidinone was found to be a good synthon for anchoring glucosyl moieties onto amines and thiols. The present method was successfully applied to establish a new route for the synthesis of urea-tethered neoglycoconjugates and pseudooligosaccharides in water.