methyl 2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose | 40269-08-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose
• 英文别名: (2S,3R,6S)-6-(aminomethyl)-2-methoxyoxan-3-amine
• CAS: 40269-08-7
• 化学式: C₇H₁₆N₂O₂
• 分子量: 160.216
• InChiKey: KYSLERXPHKJIAU-XVMARJQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose 在 硫酸 、 碳酸氢钠 作用下， 以 吡啶 、 硝基甲烷 、 溶剂黄146 为溶剂， 反应 6.0h， 生成 1-O-acetyl-2,3,4,6-tetradeoxy-2,6-bis-(2,4-dinitrophenylamino)-α-D-erythro-hexopyranose
  参考文献：
  名称：

  Ludin, Christian; Schwesinger, Berit; Schwesinger, Reinhard, Journal of the Chemical Society. Perkin transactions I, 1994, # 19, p. 2685 - 2702

  摘要：

  DOI：
• 作为产物：
  描述：

  (2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran 在 palladium on activated charcoal 1,3,5-三甲基吡唑 、 sodium tetrahydroborate 、 氢气 、 sodium cyanoborohydride 、 碳酸氢钠 、 亚硝酰氯 作用下， 以 甲醇 、 乙醇 、 水 、 溶剂黄146 、 丙酮 为溶剂， -78.0~25.0 ℃ 、5.0 MPa 条件下， 反应 35.5h， 生成 methyl 2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose
  参考文献：
  名称：

  Ludin, Christian; Schwesinger, Berit; Schwesinger, Reinhard, Journal of the Chemical Society. Perkin transactions I, 1994, # 19, p. 2685 - 2702

  摘要：

  DOI：

文献信息

• Synthesis of 2″-oxidized derivatives of 5-deoxy-5-epi-5-fluoro-dibekacin and -arbekacin, and study on structure-chemical shift relationships of urethane(or amide)-type NH protons in synthetic intermediates
  作者：Yoshihiko Kobayashi、Tsutomu Tsuchiya

  DOI：10.1016/s0008-6215(96)00318-7

  日期：1997.3

  Three 2''-modified dibekacin-analogs have been prepared as potential compounds active against resistant bacteria producing 2''-O-phosphotransferases; one is 5-deoxy-5,2''-diepi-5-fluorodibekacin (9) prepared from a suitably protected 2''-O-triflyl derivative through the 2'',3''-cyclic carbamate, and the others are 2''-oxo derivatives (12 and 22, both as the hydrate) of 5-deoxy-5-epi-5-fluoro-dibekacin and -arbekacin prepared through oxidation at C-2'' of suitably protected derivatives. Relationships between the t-butoxycarbonyl(= Boc)-NH-shifts of per-N-Boc synthetic intermediates and their structures were studied. It was found that the shifts, measured in pyridine-d(5) at 80 degrees C, which spread over a close range (delta 6-7 ppm), are sensitively influenced by nearby and surrounding groups around the BocNH group in respect of electron-withdrawing character, hydrogen bonding (BocNH ... acceptor), and also solvent effects (BocNH ... NC5H5). (C) 1997 Elsevier Science Ltd.