(-)-(1'R,2'S,5'R)-1-(2'-isopropyl-5'-methylcyclohexyloxy)acetaldehyde | 76993-59-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (-)-(1'R,2'S,5'R)-1-(2'-isopropyl-5'-methylcyclohexyloxy)acetaldehyde
• 英文别名: (-)-menthoxyacetaldehyde；((1R)-menthyloxy)-acetaldehyde；((1R)-Menthyloxy)-acetaldehyd；2-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxyacetaldehyde
• CAS: 76993-59-4
• 化学式: C₁₂H₂₂O₂
• 分子量: 198.305
• InChiKey: HMKVDFLBZALYJQ-GRYCIOLGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  [1,1'-二(环己烷)]-2,2'-二醇(异构体混合物) 、 (-)-(1'R,2'S,5'R)-1-(2'-isopropyl-5'-methylcyclohexyloxy)acetaldehyde 生成 (1R,2R,7S,11S)-9-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxymethyl]-8,10-dioxatricyclo[9.4.0.02,7]pentadecane
  参考文献：
  名称：

  BELL, T. W., J. AMER. CHEM. SOC., 1981, 103, N 5, 1163-1171

  摘要：

  DOI：
• 作为产物：
  描述：

  ((1R)-menthyloxy)-acetaldehyde diethylacetal 在 硫酸 作用下， 生成 (-)-(1'R,2'S,5'R)-1-(2'-isopropyl-5'-methylcyclohexyloxy)acetaldehyde
  参考文献：
  名称：

  Fentanyl is more effective than remifentanil at preventing increases in cerebral blood flow velocity during intubation in children

  摘要：

  Purpose: Controlling the cerebral and systemic hemodynamic responses to laryngoscopy and tracheal intubation may play a role in determining clinical outcome in pediatric neurosurgical patients. This study compared the effects of remifentanil and fentanyl on cerebral blood flow velocity (CBFV) and hemodynamic profile during laryngoscopy and tracheal intubation in children under sevoflurane anesthesia.Methods: Sixty healthy children aged two to six years undergoing dental surgery under general anesthesia were enrolled. Each child was randomly assigned to receive a remifentanil or fentanyl infusion, at a rate of 0.75, 1.0, or 1.5 mug(.)kg(-1.)min(-1) after induction of anesthesia with 2% sevoflurane. Middle cerebral artery blood flow velocity was measured by transcranial Doppler (TCD) sonography. Once a baseline set of hemodynamic variables and TCD measurements were recorded, the opioid infusion was started. Measurements were taken at two-minute intervals, starting four minutes prior to laryngoscopy until four minutes following naso-tracheal intubation.Results: Remifentanil caused a more significant decrease in mean arterial pressure and CBFV prior to tracheal intubation than did fentanyl (P < 0.001). During laryngoscopy and for two minutes following tracheal intubation, CBFV increased in all remifentanil groups (P < 0.05), whereas it remained stable in all fentanyl groups.Conclusion: This study suggests that fentanyl was more effective than remifentanil at preventing increases in CBFV during and immediately following laryngoscopy and tracheal intubation in children undergoing sevoflurane anesthesia. Fentanyl also seemed to provide a more stable hemodynamic profile prior to laryngoscopy and tracheal intubation when compared to remifentanil.

  DOI：

  10.1007/bf03017905

文献信息

• Synthesis and complexation properties of macrocyclic polyethers derived from chiral and meso-1,1'-bicyclohexyl-2,2'-diols
  作者：Thomas W. Bell

  DOI：10.1021/ja00395a028

  日期：1981.3
• Ortiz, Javier; Guijarro, Albert; Yus, Miguel, Anales de Quimica, 1997, vol. 93, # 1, p. 44 - 48
  作者：Ortiz, Javier、Guijarro, Albert、Yus, Miguel

  DOI：——

  日期：——