(12-bromododecyl)triethylene glycol | 1174656-62-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (12-bromododecyl)triethylene glycol
• CAS: 1174656-62-2
• 化学式: C₁₈H₃₇BrO₄
• 分子量: 397.393
• InChiKey: YSNIYUIPNPQVID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.32
• 重原子数：
  23.0
• 可旋转键数：
  20.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (12-bromododecyl)triethylene glycol 在 硫脲 、 乙二胺 作用下， 以 乙醇 为溶剂， 反应 36.0h， 以0.51 g的产率得到1-(mercaptododec-12-yl)triethylene glycol
  参考文献：
  名称：

  Creating Protein-Imprinted Self-Assembled Monolayers with Multiple Binding Sites and Biocompatible Imprinted Cavities

  摘要：

  Imprinted monolayers have several advantages over bulk imprinted polymers such as excellent mass transfer of molecules into and out of imprinted sites and transduction of binding signals detected in real time. Protein-imprinted self-assembled monolayers (SAMs) were created with multiple binding sites and biocompatible imprinted cavities from functional thiols and novel disulfide compounds containing an oligoethylene glycol (OEG) terminal moiety and two amide groups incorporated in the chain (DHAP) in a biologically benign solution. DHAP played an important role in the formation of multiple binding sites and biocompatible cavities in addition to resisting nonspecific protein binding. The created protein-imprinted SAMs exhibited the excellent ability of specific binding of target proteins determined by multiple binding sites and imprinted cavities. The strategy generates tailor-made monolayer surfaces with specific protein binding and opens the possibility of controlled assembly of intellectual biomaterials and preparation of biosensors.

  DOI：

  10.1021/ja402423r
• 作为产物：
  描述：

  1,12-二溴十二烷 、 三乙二醇 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 生成 (12-bromododecyl)triethylene glycol
  参考文献：
  名称：

  Synthesis of phosphorylcholine–oligoethylene glycol–alkane thiols and their suppressive effect on non-specific adsorption of proteins

  摘要：

  A series of hosphorylcholine-oligoethylene glycol-alkane thiols were synthesized, and their suppressive effect on the non-specific adsorption of proteins was evaluated by comparison with corresponding oligoethylene glycol-alkane thiols. it was found that phosphorylcholine-oligoethylene glycol-alkane thiols had a greater suppressive effect on the non-specific adsorption of proteins. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.091