(2R,3S,4S,5S,6R)-3,4-Bis-benzyloxy-2-((S)-1,2-bis-benzyloxy-ethyl)-6-ethylsulfanyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran | 188435-15-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5S,6R)-3,4-Bis-benzyloxy-2-((S)-1,2-bis-benzyloxy-ethyl)-6-ethylsulfanyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran
• CAS: 188435-15-6
• 化学式: C₄₅H₅₀O₇S
• 分子量: 734.954
• InChiKey: BSEJVHZSQUVNKN-WRLVAQMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.03
• 重原子数：
  53.0
• 可旋转键数：
  20.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.61
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  (2R,3S,4S,5S,6R)-3,4-Bis-benzyloxy-2-((S)-1,2-bis-benzyloxy-ethyl)-6-ethylsulfanyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran 在 4 A molecular sieve 、 DMTST 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 乙醚 、 二氯甲烷 、 水 为溶剂， 反应 1.67h， 生成
  参考文献：
  名称：

  Synthesis of L-glycero-D-manno-heptopyranose-containing oligosaccharide structures found in lipopolysaccharides from Haemophilus influenzae

  摘要：

  Syntheses are described of the tetrasaccharide 2-(4-trifluoroacetamidophenyl)ethyl O-(beta-D-galactopyranosyl)-(1 --> 2)-O-(L-glycero-alpha-D-manno-heptopyranosyl)-(1 --> 2)-O-(L-glycero-alpha-D--manno-heptopyranosyl)-(1 --> 3)-L-glycero-alpha-D-mnnno-heptopyranoside (20) and the three trisaccharides 2-(4-trifluoroacetamidophenyl)ethyl O-(L-glycero-alpha-D-manno-heptopyranosyl)-(1 --> 2)-O-(L-glycero-alpha-D-manno-heptopyranosl)-(1 --> 3)-L-glycero-alpha-D-manno-heptopyranoside(17), 2-(4-trifluoroacetamidophenyl)ethyl O-(beta-D-glucopyranosyl)-(1 --> 4)-O-(beta-D-glucopyranosyl)-(1 --> 4)-L-glycero-alpha-D-manno-heptopyranoside (5), and 2-(4-trifluoroacetamidophenyl)ethyl O-(beta-D-galactopyranosyl)-(1 --> 4)-O-(beta-D-glucopyranosyl)-(1 --> 4)-L-glycero-alpha-D-manno-heptopyranoside (8), corresponding to structures found in the lipooligosaccharides of Haemophilus influenzae. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(96)00275-3
• 作为产物：
  描述：

  Acetic acid (2R,3S,4S,5S,6R)-4,5-bis-benzyloxy-6-((S)-1,2-bis-benzyloxy-ethyl)-2-ethylsulfanyl-tetrahydro-pyran-3-yl ester 在 sodium methylate 、 sodium hydride 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.83h， 生成 (2R,3S,4S,5S,6R)-3,4-Bis-benzyloxy-2-((S)-1,2-bis-benzyloxy-ethyl)-6-ethylsulfanyl-5-(4-methoxy-benzyloxy)-tetrahydro-pyran
  参考文献：
  名称：

  Synthesis of L-glycero-D-manno-heptopyranose-containing oligosaccharide structures found in lipopolysaccharides from Haemophilus influenzae

  摘要：

  Syntheses are described of the tetrasaccharide 2-(4-trifluoroacetamidophenyl)ethyl O-(beta-D-galactopyranosyl)-(1 --> 2)-O-(L-glycero-alpha-D-manno-heptopyranosyl)-(1 --> 2)-O-(L-glycero-alpha-D--manno-heptopyranosyl)-(1 --> 3)-L-glycero-alpha-D-mnnno-heptopyranoside (20) and the three trisaccharides 2-(4-trifluoroacetamidophenyl)ethyl O-(L-glycero-alpha-D-manno-heptopyranosyl)-(1 --> 2)-O-(L-glycero-alpha-D-manno-heptopyranosl)-(1 --> 3)-L-glycero-alpha-D-manno-heptopyranoside(17), 2-(4-trifluoroacetamidophenyl)ethyl O-(beta-D-glucopyranosyl)-(1 --> 4)-O-(beta-D-glucopyranosyl)-(1 --> 4)-L-glycero-alpha-D-manno-heptopyranoside (5), and 2-(4-trifluoroacetamidophenyl)ethyl O-(beta-D-galactopyranosyl)-(1 --> 4)-O-(beta-D-glucopyranosyl)-(1 --> 4)-L-glycero-alpha-D-manno-heptopyranoside (8), corresponding to structures found in the lipooligosaccharides of Haemophilus influenzae. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(96)00275-3