(3R,3aR,9aS)-5,5,7,7-Tetraisopropyl-2-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol | 188477-15-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,3aR,9aS)-5,5,7,7-Tetraisopropyl-2-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol
• CAS: 188477-15-8
• 化学式: C₁₈H₃₈O₆Si₂
• 分子量: 406.667
• InChiKey: WSCLYCQPYILECV-KTGAGVNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.38
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (3R,3aR,9aS)-5,5,7,7-Tetraisopropyl-2-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol 在 吡啶 、 三甲基氯硅烷 、 sodium azide 、 硫酸 、 氢氟酸 、 四氯化锡 、 溶剂黄146 、 N,N'-硫羰基二咪唑 、 六甲基二硅氮烷 作用下， 生成 Acetic acid (2R,3R,5R)-5-azidomethyl-2-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
  参考文献：
  名称：

  Synthesis of base-modified dihydropacidamycins

  摘要：

  We describe in this paper the synthesis of 1,2-di-O-acetyl-5-azido-3,5-dideoxy-alpha,beta-L-arabinofuranose, a carbohydrate donor that was used for the synthesis of 1-(5'-amino-3',5'-dideoxy-alpha-L-arabinofuranosyl)uracil, the nucleoside found in dihydropacidamycin D. The carbohydrate donor was also used for the synthesis of a set of new nucleosides that were introduced in new dihydropacidamycins. These compounds were tested for biological activity, and the results showed that uracil is the only base recognized by MraY. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00100-2
• 作为产物：
  描述：

  甲醇 、 D-吡喃木糖 、 1,3二氯-1,1,3,3-四异丙基二硅氧烷 在 甲烷磺酸 作用下， 反应 0.67h， 生成 (3R,3aR,9aS)-5,5,7,7-Tetraisopropyl-2-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol
  参考文献：
  名称：

  Synthesis of base-modified dihydropacidamycins

  摘要：

  We describe in this paper the synthesis of 1,2-di-O-acetyl-5-azido-3,5-dideoxy-alpha,beta-L-arabinofuranose, a carbohydrate donor that was used for the synthesis of 1-(5'-amino-3',5'-dideoxy-alpha-L-arabinofuranosyl)uracil, the nucleoside found in dihydropacidamycin D. The carbohydrate donor was also used for the synthesis of a set of new nucleosides that were introduced in new dihydropacidamycins. These compounds were tested for biological activity, and the results showed that uracil is the only base recognized by MraY. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00100-2