methyl (methyl 3-deoxy-9-O-p-toluenesulfonyl-D-glycero-α-D-galacto-2-nonulopyranosid)onate | 361206-46-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (methyl 3-deoxy-9-O-p-toluenesulfonyl-D-glycero-α-D-galacto-2-nonulopyranosid)onate
• 英文别名: methyl (2R,4S,5R,6R)-6-[(1R,2R)-1,2-dihydroxy-3-(4-methylphenyl)sulfonyloxypropyl]-4,5-dihydroxy-2-methoxyoxane-2-carboxylate
• CAS: 361206-46-4
• 化学式: C₁₈H₂₆O₁₁S
• 分子量: 450.464
• InChiKey: YHZNYGAVCACYAI-DGYIVEFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  177
• 氢给体数：
  4
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  methyl (methyl 3-deoxy-9-O-p-toluenesulfonyl-D-glycero-α-D-galacto-2-nonulopyranosid)onate 在 palladium on activated charcoal 叠氮化锂 、 氢气 、 溶剂黄146 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 50.0 ℃ 、344.74 kPa 条件下， 反应 156.0h， 生成 methyl (methyl 9-amino-3,9-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate
  参考文献：
  名称：

  THE SYNTHESIS OF C-9 MODIFIED DERIVATIVES OF THE α-METHYL GLYCOSIDE OF KDN METHYL ESTER

  摘要：

  The synthesis of a range of C-9 substituted derivatives of the cc-methyl glycoside of KDN methyl ester (2) is reported. 9-Deoxy-9-iodo, 9-deoxy-9 thioacetyl and 9-azido-9-deoxy derivatives (compounds 10, 12 and 13) were all prepared from the corresponding 9-O-tosylate 8. Catalytic hydrogenation of 10 and 13 results in reduction to give the 9-deoxy and 9-amino-9-deoxy derivatives 20 and 15, respectively. Further derivatisation of the amine 15 into compounds 17 and 18 was achieved via standard acylation procedures.

  DOI：

  10.1081/car-100103960
• 作为产物：
  描述：

  methyl (methyl 4,5,7,8,9-penta-O-acetyl-3-deoxy-D-glycero-α-D-galacto-2-nonulopyranosid)onate 在 吡啶 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 methyl (methyl 3-deoxy-9-O-p-toluenesulfonyl-D-glycero-α-D-galacto-2-nonulopyranosid)onate
  参考文献：
  名称：

  THE SYNTHESIS OF C-9 MODIFIED DERIVATIVES OF THE α-METHYL GLYCOSIDE OF KDN METHYL ESTER

  摘要：

  The synthesis of a range of C-9 substituted derivatives of the cc-methyl glycoside of KDN methyl ester (2) is reported. 9-Deoxy-9-iodo, 9-deoxy-9 thioacetyl and 9-azido-9-deoxy derivatives (compounds 10, 12 and 13) were all prepared from the corresponding 9-O-tosylate 8. Catalytic hydrogenation of 10 and 13 results in reduction to give the 9-deoxy and 9-amino-9-deoxy derivatives 20 and 15, respectively. Further derivatisation of the amine 15 into compounds 17 and 18 was achieved via standard acylation procedures.

  DOI：

  10.1081/car-100103960

文献信息

• THE SYNTHESIS OF C-9 MODIFIED DERIVATIVES OF THE α-METHYL GLYCOSIDE OF KDN METHYL ESTER
  作者：Adele K. Norton、Gaik B. Kok、Mark von Itzstein

  DOI：10.1081/car-100103960

  日期：2001.3.31

  The synthesis of a range of C-9 substituted derivatives of the cc-methyl glycoside of KDN methyl ester (2) is reported. 9-Deoxy-9-iodo, 9-deoxy-9 thioacetyl and 9-azido-9-deoxy derivatives (compounds 10, 12 and 13) were all prepared from the corresponding 9-O-tosylate 8. Catalytic hydrogenation of 10 and 13 results in reduction to give the 9-deoxy and 9-amino-9-deoxy derivatives 20 and 15, respectively. Further derivatisation of the amine 15 into compounds 17 and 18 was achieved via standard acylation procedures.