4-硝基苯基甘氨酸 | 17639-39-3

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 甘氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-硝基苯基甘氨酸
• 英文名称: p-nitrophenyl glycinate
• 英文别名: Glycin-<4-nitro-phenylester>；Glycin-(4-nitro-phenylester)；Glycin-4-nitro-phenylester；Glycin-p-nitrophenylester；p-Nitrophenyl-glycinat；Gly-OPNP；4-Nitrophenyl 2-aminoacetate；(4-nitrophenyl) 2-aminoacetate
• CAS: 17639-39-3
• 化学式: C₈H₈N₂O₄
• mdl: MFCD04037437
• 分子量: 196.163
• InChiKey: KGONNPXPJQKSGN-UHFFFAOYSA-N

物化性质

• 沸点：
  358.7±27.0 °C(Predicted)
• 密度：
  1.375±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  98.1
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  4-硝基苯基甘氨酸 、 丁酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 0.5h， 生成 N-Butyryl-glycine-p-nitrophenol ester
  参考文献：
  名称：

  Synthesis of glutamate receptor antagonist philanthotoxin-433 (PhTX-433) and its analogs

  摘要：

  DOI：

  10.1016/s0040-4020(01)85463-6
• 作为产物：
  描述：

  N-苄氧羰基甘氨酸-4-硝基苯酯 在 氢溴酸 、 溶剂黄146 作用下， 生成 4-硝基苯基甘氨酸
  参考文献：
  名称：

  Schnabel,E., Justus Liebigs Annalen der Chemie, 1964, vol. 673, p. 171 - 175

  摘要：

  DOI：

文献信息

• The potential of N-alkoxymethyl groups as peptide backbone protectants
  作者：Ana I. Fernández-Llamazares、Jan Spengler、Fernando Albericio

  DOI：10.1016/j.tetlet.2013.10.149

  日期：2014.1

  In this study, the potential of N-alkoxymethyl groups as protectants for the peptide backbone has been investigated. These groups were found to be compatible with the standard conditions of Fmoc/tBu SPPS, and can be cleaved off from the peptide backbone by acids. Thus, backbone N-alkoxymethyl groups may be useful to prevent undesired side-reactions and/or interchain aggregation during peptide elongation

  在该研究中，已经研究了N-烷氧基甲基基团作为肽主链保护剂的潜力。发现这些基团与Fmoc / t Bu SPPS的标准条件相容，并且可以被酸从肽主链上裂解下来。因此，主链N-烷氧基甲基可用于防止在固相上的肽延伸过程中不期望的副反应和/或链间聚集。然而，它们作为保护基应用的主要问题是难以将它们掺入肽主链中。
• Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
  申请人：DR. REDDY'S LABORATORIES LIMITED

  公开号：US20030229083A1

  公开（公告）日：2003-12-11

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), 1 their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

  本发明涉及具有化学式（I）的新型抗糖尿病、降血脂、抗肥胖和降胆固醇化合物，其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化物以及含有它们的药学上可接受的组合物。
• [EN] BASIC SALTS AND MONOHYDRATES OF CERTAIN ALPHA, BETA-PROPRIONIC ACID DERIVATIVE<br/>[FR] SELS DE BASE ET MONOHYDRATES DE CERTAINS DERIVES D'ACIDE ALPHA, BETA-PROPRIONIQUE
  申请人：REDDYS LAB LTD DR

  公开号：WO2006001795A1

  公开（公告）日：2006-01-05

  The invention provides novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid, including Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propilamino}phenyl] proprionic acid monohydrate, Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid, and (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid monohydrate. Various aspects and embodiments are included. Compositions containing novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid are also provided.

  本发明提供了(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸的新型盐，包括(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸精氨酸盐单水合物、(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸精氨酸盐和(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸单水合物。本发明还包括各种方面和实施例。本发明还提供了含有(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸新型盐的组合物。
• Basic salts and monohydrates of certain alpha, beta-propionic acid derivative
  申请人：Palle Venkata Raghavendra Charyulu

  公开号：US20050277693A1

  公开（公告）日：2005-12-15

  The invention provides novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid, including Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid monohydrate, Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl) propylamino} phenyl] propionic acid, and (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid monohydrate. Various aspects and embodiments are included. Compositions containing novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl) propylamino}phenyl] propionic acid are also provided.

  本发明提供了(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸的新型盐，包括(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸单水合物的精氨酸盐，(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸的精氨酸盐，以及(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸单水合物。包括各种方面和实施例。还提供了含有(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸新型盐的组合物。
• Phosphonium salt and its use
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04173563A1

  公开（公告）日：1979-11-06

  The amidation and esterification of carboxylic acids with amines and hydroxyl group-containing compounds, respectively, are effected without incurring the drawbacks of reaction equilibrium by the reaction of the reactants, one of which has been activated in the reactive group by contact with a phosphonium salt obtained by reacting a phosphorous ester or phosphorous monoester salt with an organic base such as pyridine and an oxidizing agent such as halogens and mono or divalent mercury halide or acetate. The amidation can be applied to the preparation of peptides by the reaction of amino acids and/or peptides in which one of the reactive groups have been protected.

  通过将含有氨基和羟基的化合物分别与羧酸进行酰胺化和酯化，而不会产生反应平衡的缺点，是通过反应物之一与磷酸铵盐接触而激活反应基团来实现的。磷酸铵盐是通过将磷酸酯或磷酸单酯盐与有机碱（如吡啶）和氧化剂（如卤素和一价或二价汞卤化物或醋酸盐）反应而得到的。酰胺化可以应用于通过保护反应基团中的一个来反应氨基酸和/或肽制备肽。