维甲酸钠盐 | 13497-05-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 维甲酸钠盐
• 中文别名: 维生素A酸钠盐；视黄酸钠盐
• 英文名称: sodium trans-retinoleate
• 英文别名: Sodium retinoate；sodium;(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
• CAS: 13497-05-7
• 化学式: C₂₀H₂₇O₂*Na
• 分子量: 322.423
• InChiKey: MLZFHHXDDHGSIR-ABAXVIISSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.27
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-二乙氨基-1-溴乙烷氢溴酸盐 、 维甲酸钠盐 以 乙腈 为溶剂， 以72.9%的产率得到N,N-diethylaminoethyl trans-retinoate hydrobromide
  参考文献：
  名称：

  非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ

  摘要：

  设计和合成带有新正电荷的構造31型视黄醇或类视黄醇化合物的前药。这些前药中的带正电荷的氨基不仅显著增加了药物在水中的溶解性，还与磷脂膜头部基的负电荷结合。这种结合不仅会轻微干扰膜，还可以为前药的疏水部分提供空间。当膜分子移动时，由于前药的结合，膜会出现微小的“裂缝”，这使得前药能够插入膜中。前药可以在人类或动物中医药上使用，治疗患有视黄醇或类视黄醇化合物可治疗状态的疾病。前药可以经皮途径用于任何类型的医学治疗，并且可以避免大部分视黄醇或类视黄醇化合物的副作用。【图示】图2

  公开号：

  JP2019006795A

文献信息

• HIGH PENETRATION PRODRUG COMPOSITIONS OF RETINOIDS AND RETINOID-RELATED COMPOUNDS
  申请人：Yu Chongxi

  公开号：US20100010084A1

  公开（公告）日：2010-01-14

  The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of retinoids and retinoid-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

  本发明提供了一种新型高穿透力(retinoids)和相关化合物的高穿透力前药(HPP)或高穿透力制剂(HPC)的组合物，能够高效地穿过生物屏障。HPP能够在穿过生物屏障后转化为原活性药物或药物代谢物，从而可以治疗与原药物或代谢物相关的疾病。此外，HPP能够到达原药物无法进入或无法在目标区域达到足够浓度的区域，从而提供新的治疗方法。HPP可以通过各种给药途径给予受试者，例如在治疗区域局部给药以高浓度作用或全身给药以更快的速率进入循环系统。
• MULTILAYER FILM AND INTERMEDIATE FILM FOR LAMINATED GLASS FORMED OF SAME
  申请人：Kuraray Co., Ltd.

  公开号：EP3064352A1

  公开（公告）日：2016-09-07

  There is provided a multilayer film comprising a layer (X) containing a polyvinyl acetal (I) having an acetalization degree of 55 to 80 mol%, a content of a vinyl ester monomer unit of 0.1 to 1.5 mol% and a viscosity-average degree of polymerization of 1,400 to 5,000; and a layer (Y) containing a polyvinyl acetal (II) having an acetalization degree of 70 to 85 mol%, a content of a vinyl ester monomer unit of 5 to 15 mol% and a viscosity-average degree of polymerization of 1,400 to 5,000, wherein the multilayer film satisfies formulas (1) and (2): (A-B)/A < 0.80 (1) and 1.00 × 10-2 < (b/y)/(a/x) < 2.00 × 10-1 (2). There is thus provided a film which exhibits sufficient sound-absorbability, resistance to coloration by heating, reduction in foreign materials (undissolved materials) and excellent recyclability.

  提供了一种多层薄膜，包括一层（X），该层含有聚乙烯醇缩醛（I），其缩醛度为 55 至 80 摩尔%，乙烯基酯单体单元含量为 0.1 至 1.5 摩尔%，粘度平均聚合度为 1,400 至 5,000 度；以及一层（Y），该层含有聚乙烯醇缩醛（II），其缩醛度为 70 至 85 摩尔%。5 mol%，平均聚合粘度为 1,400 至 5,000 度；以及一层 (Y)，该层含有聚乙烯醇缩醛 (II)，其缩醛度为 70 至 85 mol%，乙烯基酯单体单元含量为 5 至 15 mol%，平均聚合粘度为 1,400 至 5,000 度，其中多层膜满足式 (1) 和 (2)：(A-B)/A < 0.80 (1)和 1.00 × 10-2 < (b/y)/(a/x) < 2.00 × 10-1 (2)。因此，本发明提供的薄膜具有足够的吸音性、耐加热着色性、减少异物（未溶解物质）和出色的可回收性。
• BINDER FOR FORMATION OF CERAMIC OR FOR USE IN CONDUCTIVE PASTE, AND USE OF SAME
  申请人：Kuraray Co., Ltd.

  公开号：EP3109263A9

  公开（公告）日：2017-04-12

  There is provided a binder for ceramic formation or a conductive paste, comprising polyvinyl acetal having a degree of acetalization of from 50 to 85 mol%, a content of vinyl ester monomer unit of from 0.1 to 20 mol%, and having a viscosity-average degree of polymerization of from 200 to 5000, wherein a peak-top molecular weight (A) as measured by a differential refractive index detector and a peak-top molecular weight (B) as measured by an absorptiometer (measurement wavelength: 280 nm) in gel permeation chromatographic measurement of the polyvinyl acetal heated at 230°C for 3 hours satisfy a formula (1) (A-B)/A < 0.60 and the polyvinyl acetal has an absorbance in the peak-top molecular weight (B) of from 0.50 × 10-3 to 1.00 × 10-2.

  提供了一种用于陶瓷成型或导电浆料的粘结剂，它包括聚乙烯醇缩醛，其缩醛度为 50 至 85 摩尔%，乙烯基酯单体单元含量为 0.其中，在凝胶渗透色谱法测量在 230°C 下加热 3 小时的聚乙烯醇缩醛时，用差分折射率检测器测得的峰顶分子量 (A) 和用吸收仪（测量波长：280 纳米）测得的峰顶分子量 (B) 满足式 (1) (A-B)/A < 0.60，且聚乙烯醇缩醛的峰顶分子量（B）吸光度为 0.50 × 10-3 至 1.00 × 10-2。
• INTERLAYER FOR LAMINATED GLASS
  申请人：Kuraray Co., Ltd.

  公开号：EP3109213A1

  公开（公告）日：2016-12-28

  An objective of the invention is to provide: an interlayer which is for use in a laminated glass comprising a polyvinyl acetal, which is less discolored by heating and contains less foreign materials (undissolved materials), and in which light-diffusing fine particles are dispersed in a non-agglomerated state. Another objective is to provide a laminated glass, in which, even when the interlayer film for a laminated glass is produced after repeated heating, light-diffusing fine particles are dispersed in a non-agglomerated state, and which exhibits excellent penetration resistance, excellent transparency and excellent light-diffusing properties with the use of the interlayer film. There is provided an interlayer film for a laminated glass comprising a polyvinyl acetal with an acetalization degree of 60 to 80 mol%, a content of a vinyl ester monomer unit of 0.1 to 20 mol% and a viscosity-average degree of polymerization of 1400 to 4000, and light-diffusing fine particles, wherein a difference absolute value between a refractive index of the light-diffusing fine particles and a refractive index of the composition free from the light-diffusing fine particles is 0.20 or more and a haze as measured in accordance with JIS K 7105 for a laminated glass prepared by sandwiching the interlayer film for a laminated glass between two glass sheets with a thickness of 3 mm is 20 % or less, and the interlayer film for a laminated glass satisfies formulas (1) and (2): A−B/A<0.80 1.00×10−2

  本发明的一个目的是提供一种用于夹层玻璃的中间膜，该中间膜由聚乙烯醇缩醛组成，加热后变色较少，含有较少的异物（未溶解物），并且其中的光扩散微粒以非团聚状态分散。另一个目的是提供一种夹层玻璃，在使用该夹层玻璃用中间膜时，即使在反复加热后生成夹层玻璃用中间膜，光扩散细微颗粒也能以非团聚状态分散，并且具有优异的抗渗透性、优异的透明度和优异的光扩散特性。提供了一种夹层玻璃用中间膜，该中间膜由聚乙烯醇缩醛（缩醛度为 60 至 80 摩尔%，乙烯基酯单体单元含量为 0.1 至 20 摩尔%，粘度-平均聚合度为 1400 至 4000）和光扩散微粒组成，其中光扩散微粒的折射率与不含光扩散微粒的组合物的折射率之差的绝对值为 0.根据 JIS K 7105 测量，将夹层玻璃用中间膜夹在厚度为 3 mm 的两片玻璃之间制备的夹层玻璃的雾度为 20 % 或以下，且夹层玻璃用中间膜满足公式 (1) 和 (2)：A−B/A<0.80 1.00×10−2
• Multilayer film and interlayer film for laminated glass therefrom
  申请人：KURARAY CO., LTD.

  公开号：US10016959B2

  公开（公告）日：2018-07-10

  There is provided a multilayer film comprising a layer (X) containing a polyvinyl acetal (I) having an acetalization degree of 55 to 80 mol %, a content of a vinyl ester monomer unit of 0.1 to 1.5 mol % and a viscosity-average degree of polymerization of 1,400 to 5,000; and a layer (Y) containing a polyvinyl acetal (II) having an acetalization degree of 70 to 85 mol %, a content of a vinyl ester monomer unit of 5 to 15 mol % and a viscosity-average degree of polymerization of 1,400 to 5,000, wherein the multilayer film satisfies formulas (1) and (2): (A−B)/A<0.80  (1) and 1.00×10−2<(b/y)/(a/x)<2.00×10−1  (2). There is thus provided a film which exhibits sufficient sound-absorbability, resistance to coloration by heating, reduction in foreign materials (undissolved materials) and excellent recyclability.

  提供了一种多层薄膜，其中一层（X）含有聚乙烯醇缩醛（I），其缩醛度为 55 至 80 摩尔 %，乙烯基酯单体单元含量为 0.1 至 1.5 mol %，平均聚合粘度为 1,400 至 5,000 ；以及一层（Y），该层含有聚乙烯醇缩醛（II），其缩醛度为 70 至 85 mol %，乙烯基酯单体单元含量为 5 至 15 mol %，平均聚合粘度为 1,400 至 5,000 ，其中多层膜满足式（1）和（2）： (a-b)/a<0.80 (1) 和 1.00×10-2<(b/y)/(a/x)<2.00×10-1 (2)。 这样就提供了一种薄膜，它具有足够的吸音性、耐加热着色性、减少异物（未溶解物质）和出色的可回收性。