α-amyrin | 5937-48-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: α-amyrin
• 英文别名: 3-epi-alpha-Amyrin；(3R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol
• CAS: 5937-48-4
• 化学式: C₃₀H₅₀O
• 分子量: 426.726
• InChiKey: FSLPMRQHCOLESF-ACUMZOKISA-N

物化性质

• 熔点：
  134-137 °C
• 沸点：
  493.8±45.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  olibanumol K 在 水 、 potassium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以0.8 mg的产率得到α-amyrin
  参考文献：
  名称：

  Four New Ursane-Type Triterpenes, Olibanumols K, L, M, and N, from Traditional Egyptian Medicine Olibanum, the Gum-Resin of Boswellia carterii

  摘要：

  从埃及传统药物橄榄油（Boswellia carterii BIRDW 的渗出胶树脂）中分离出了四种新的熊烷型三萜类化合物，即橄榄油醇 K (1)、L (2)、M (3) 和 N (4)。根据化学和物理化学证据阐明了它们的结构。

  DOI：

  10.1248/cpb.58.1541

文献信息

• NOVEL BOSWELLIA LOW POLAR GUM RESIN EXTRACT AND ITS SYNERGISTIC COMPOSITIONS
  申请人：GOKARAJU Ganga Raju

  公开号：US20120301432A1

  公开（公告）日：2012-11-29

  The present disclosure describes Boswellia low polar gum resin extract (BLPRE) comprising novel phytochemical composition of sesquiterpenes, diterpenes, triterpenes and other phytochemical(s) obtained from gum resin of Boswellia species. The present disclosure also describes compositions comprising BLPRE in combination with one or more component(s) selected from biologically active ingredient(s), functional ingredient(s), excipient(s), diluents(s), carrier(s) and additive(s) or mixtures thereof. Further the present disclosure also provides synergistic composition(s) comprising Boswellia low polar gum resin extract (BLPRE) and at least one component selected from but not limited to extract(s), fraction(s), phytochemical(s) or their salts or mixtures thereof derived from Boswellia species or Curcuma species.

  本公开说明书描述了一种低极性树脂提取物（BLPRE），其包含从乳香树脂中获得的倍半萜、二萜、三萜和其他植物化学物质的新型植物化学成分。本公开说明书还描述了包含BLPRE的组合物，其与生物活性成分、功能性成分、赋形剂、稀释剂、载体和添加剂或其混合物中的一个或多个成分组合使用。此外，本公开说明书还提供了协同作用组合物，其包括乳香低极性树脂提取物（BLPRE）和至少一种从乳香种类或姜黄种类中提取的提取物、分离物、植物化学物质或其盐或混合物，但不限于此。
• Synergistic anti-inflammatory compositions comprising Boswellia serrata extract
  申请人：LAILA NUTRACEUTICALS

  公开号：US10206964B2

  公开（公告）日：2019-02-19

  The present invention discloses synergistic nutraceutical or pharmaceutical or dietary supplement anti-inflammatory compositions comprising therapeutically effective combination of an extract selectively enriched in 3-O-acetyl-1 1-keto-β-boswellic acid (AKBA) derived from Boswellia serrata and Boswellia serrata non-acidic resin extract (BNRE). The composition(s) can be used to prevent, control and treat inflammation and several inflammatory related diseases including asthma, osteoarthritis, rheumatoid arthritis, endothelial dysfunction and the like. The invention further discloses the amelioration of pro-inflammatory biomarker proteins or molecules, whose expression/production is altered during inflammatory diseases.

  本发明公开了协同营养保健品或药物或膳食补充剂抗炎组合物，该组合物包含选择性富含3-O-乙酰基-1 1-酮-β-乳香酸（AKBA）的提取物（来源于血清乳香）和血清乳香非酸性树脂提取物（BNRE）的治疗有效组合。该组合物可用于预防、控制和治疗炎症及多种炎症相关疾病，包括哮喘、骨关节炎、类风湿性关节炎、内皮功能障碍等。本发明进一步揭示了对促炎症生物标志蛋白或分子的改善作用，这些蛋白或分子的表达/产生在炎症性疾病期间会发生改变。
• Compositions comprising non-acidic Boswellia oil fraction as a bio-enhancer for enhancing bioavailability of biological agents
  申请人：LAILA NUTRACEUTICALS

  公开号：US10286023B2

  公开（公告）日：2019-05-14

  The invention relates to a non-acidic Boswellia low polar gum resin extract fraction (BLPRE) in combination with biological agents for enhancing the bioavailability of the biological agents. The invention also provides composition(s) comprising a Boswellia low polar gum resin extract (BLPRE) in combination with a biological agent for increasing the bioavailability of biological agent.

  本发明涉及一种非酸性乳香低极性胶树脂提取物馏分（BLPRE）与生物制剂的组合，用于提高生物制剂的生物利用度。本发明还提供了包含乳香低极性胶树脂提取物（BLPRE）的组合物，该组合物与生物制剂结合使用可提高生物制剂的生物利用度。
• Method and compostitions for treating coronavirus infection
  申请人：PHOENIX BIOTECHNOLOGY, INC.

  公开号：US10729735B1

  公开（公告）日：2020-08-04

  A method of treating viral infection, such as viral infection caused by a virus of the Coronaviridae family, is provided. A composition having at least oleandrin is used to treat viral infection.

  提供了一种治疗病毒感染的方法，例如由冠状病毒科病毒引起的病毒感染。一种至少含有齐墩果素的组合物用于治疗病毒感染。
• Antimicrobial prevention and treatment of human immunedeficience virus and other infectious diseases
  申请人：——

  公开号：US20030104082A1

  公开（公告）日：2003-06-05

  An improved medical treatment and medicine is provided to quickly and safely resolve HIV and other microbial infections. The inexpensive medicine can be self administered and maintained for the prescribed time. The attractive medicine comprises an antimicrobial concentrate comprising microbe inhibitors, phytochemicals or isolates. Desirably, the effective medicine comprises a surfactant and an aqueous carrier or solvent and a nutrient. In the preferred form, the medicine comprises: Echinacea and Commiphora myrrha phytochemicals, benzalkonium chloride, a sterile water solution, and folic acid.

  提供了一种改进的医疗方法和药物，可快速、安全地解决艾滋病毒和其他微生物感染问题。这种药物价格低廉，可自行服用并在规定时间内维持。这种有吸引力的药物包括一种抗微生物浓缩物，其中含有微生物抑制剂、植物化学物质或分离物。理想情况下，有效药物包括表面活性剂和水性载体或溶剂以及营养素。在优选形式中，药物包括紫锥菊和 紫锥菊 植物化学物质、苯扎氯铵、无菌水溶液和叶酸。