(R)-2-ethyl-4-methyl-pent-4-en-1-ol | 56640-41-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-2-ethyl-4-methyl-pent-4-en-1-ol
• 英文别名: (2R)-2-ethyl-4-methylpent-4-en-1-ol
• CAS: 56640-41-6
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: XNKLYDRPRIPJKF-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-2-ethyl-4-methyl-pent-4-en-1-ol 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 以72%的产率得到(2R)-2-ethyl-4-methylpent-4-enal
  参考文献：
  名称：

  Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials

  摘要：

  Introduction in therapy of the naturally occurring trioxane artemisinin opened a new era in malaria treatment and prompted the development of semisynthetic and synthetic derivatives characterized by the presence of the key peroxide bridge. The 1,2-dioxane ring is present in some natural endoperoxides Such as plakortin and dihydroplakortin, which are endowed with interesting antimalarial properties. Here we describe the development of a versatile stereocontrolled synthetic strategy to 1,2-dioxanes functionalized at the critical C3, C4, and C6 positions, potentially useful for the development of innovative antimalarials. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.137
• 作为产物：
  描述：

  ethyl-(2-methyl-allyl)-malonic acid diethyl ester 在 氢氧化钾 、 lithium aluminium tetrahydride 、 氰化钠 作用下， 以 乙醇 、 二甲基亚砜 为溶剂， 生成 (R)-2-ethyl-4-methyl-pent-4-en-1-ol
  参考文献：
  名称：

  Kirmse,W. et al., Chemische Berichte, 1975, vol. 108, p. 1839 - 1854

  摘要：

  DOI：

文献信息

• Kirmse,W. et al., Chemische Berichte, 1975, vol. 108, p. 1839 - 1854
  作者：Kirmse,W. et al.

  DOI：——

  日期：——
• Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials
  作者：Sandra Gemma、Francesc Martí、Emanuele Gabellieri、Giuseppe Campiani、Ettore Novellino、Stefania Butini

  DOI：10.1016/j.tetlet.2009.07.137

  日期：2009.10

  Introduction in therapy of the naturally occurring trioxane artemisinin opened a new era in malaria treatment and prompted the development of semisynthetic and synthetic derivatives characterized by the presence of the key peroxide bridge. The 1,2-dioxane ring is present in some natural endoperoxides Such as plakortin and dihydroplakortin, which are endowed with interesting antimalarial properties. Here we describe the development of a versatile stereocontrolled synthetic strategy to 1,2-dioxanes functionalized at the critical C3, C4, and C6 positions, potentially useful for the development of innovative antimalarials. (C) 2009 Elsevier Ltd. All rights reserved.