1,4-diacetoxy-2,3-dimethoxy-5-methyl-6-decaprenylbenzene | 55823-68-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1,4-diacetoxy-2,3-dimethoxy-5-methyl-6-decaprenylbenzene
• 英文别名: ubiquinol-10 diacetate；Coenzym-Q(10)-hydrochinon-diacetat；Ubiquinol diacetate；[4-acetyloxy-5-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-2,3-dimethoxy-6-methylphenyl] acetate
• CAS: 55823-68-2
• 化学式: C₆₃H₉₆O₆
• 分子量: 949.452
• InChiKey: LWWXMFIAISYVGL-MFUCCPPNSA-N

物化性质

• 沸点：
  876.8±65.0 °C(Predicted)
• 密度：
  0.960±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  20.4
• 重原子数：
  69
• 可旋转键数：
  35
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  水溶型辅酶 Q10 、 乙酸酐 在 吡啶 作用下， 反应 3.0h， 以7.3 g的产率得到1,4-diacetoxy-2,3-dimethoxy-5-methyl-6-decaprenylbenzene
  参考文献：
  名称：

  REDUCED COENZYME Q10 DERIVATIVE AND METHOD FOR PRODUCTION THEREOF

  摘要：

  公式（1）所代表的一种还原辅酶Q10衍生物，其中R1和R2分别独立地为H或由公式（2）表示的烷氧羰基团，且它们中至少有一个是由公式（2）表示的烷氧羰基团；在公式（2）中，R3是一个可选择地取代的线性、支链或环烷基基团，其含有1至20个碳原子，一个可选择地取代的含有6至20个碳原子的芳基基团，或一个可选择地取代的含有4至20个碳原子的杂芳基团，当R3是一个取代了聚乙二醇的基团时，聚乙二醇的分子量不超过300。

  公开号：

  US20150307440A1

文献信息

• Active oxygen chemistry within the liposomal bilayer
  作者：Michal Afri、Benjamin Ehrenberg、Yeshayahu Talmon、Judith Schmidt、Yael Cohen、Aryeh A. Frimer

  DOI：10.1016/j.chemphyslip.2004.04.007

  日期：2004.8

  We have previously shown that the location and orientation of compounds intercalated within the lipid bilayer can be qualitatively determined using an NMR chemical shift-polarity correlation. We describe herein the results of our application of this method to analogs of Vitamin E, ubiquinol and ubiquinone. The results indicate that tocopherol-and presumably the corresponding tocopheroxyl radical-reside adjacent to the interface, and can, therefore, abstract a hydrogen atom from ascorbic acid. On the other hand, the decaprenyl substituted ubiquinol and ubiquinone lie substantially deeper within the lipid membrane. Yet, contrary to the prevailing literature, their location is far from being the same. Ubiquinone-10 is situated above the long-chain fatty acid "slab". Ubiquinol-10 dwells well within the lipid slab, presumably out of "striking range" of Vitamin C. Nevertheless, ubiquinol can act as an antioxidant by reducing C- or O-centered lipid radicals or by recycling the lipid-resident tocopheroxyl radical. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
• METHODS FOR ANALYZING P-HYDROQUINONE LEVELS AND RATIOS
  申请人：HINMAN Andrew W.

  公开号：US20190241497A1

  公开（公告）日：2019-08-08

  Provided herein are compounds and methods of using the compounds for determining levels of, for example, para-hydroquinones in a sample.
• [EN] METHODS OF ANALYZING P-HYDROQUINONE LEVELS AND RATIOS<br/>[FR] PROCÉDÉS D'ANALYSE DE NIVEAUX ET DE RAPPORTS DE P-HYDROQUINONE
  申请人：BIOELECTRON TECH CORP

  公开号：WO2018081644A1

  公开（公告）日：2018-05-03

  Provided herein are compounds and methods of using the compounds for determining levels of, for example, para-hydroquinones in a sample.