(+)-(R,R)-1,3-diphenyl-1,3-propanediazide | 229018-04-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (+)-(R,R)-1,3-diphenyl-1,3-propanediazide
• 英文别名: 1,3-diphenyl-1,3-propanediazide；[(1R,3R)-1,3-diazido-3-phenylpropyl]benzene
• CAS: 229018-04-6
• 化学式: C₁₅H₁₄N₆
• 分子量: 278.316
• InChiKey: YEBRGEJEELPMQG-HUUCEWRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  28.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+)-(R,R)-1,3-diphenyl-1,3-propanediazide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以96.3%的产率得到racemic 1,3-diphenyl-1,3-propanediamine
  参考文献：
  名称：

  Synthesis of novel C2-symmetric ligands based on (R,R)- and (S,S)-diphenyl-1,3-propanediol

  摘要：

  A range of novel Ct-symmetric dioxygen and dinitrogen ligands can readily be obtained through the interconversion of the parent 1,3-diphenyl-1,3-propanediol enantiomers which are, in turn, accessed in good yields via a Sharpless asymmetric epoxidative resolution. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00074-9
• 作为产物：
  描述：

  反-1,3-二苯基-2-丙稀-1-醇 在 titanium(IV) isopropylate 、 叔丁基过氧化氢 、 sodium azide 、 3 A molecular sieve 、 D-(-)-酒石酸二异丙酯 、 三乙胺 、 红铝 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 47.0h， 生成 (+)-(R,R)-1,3-diphenyl-1,3-propanediazide
  参考文献：
  名称：

  Synthesis of novel C2-symmetric ligands based on (R,R)- and (S,S)-diphenyl-1,3-propanediol

  摘要：

  A range of novel Ct-symmetric dioxygen and dinitrogen ligands can readily be obtained through the interconversion of the parent 1,3-diphenyl-1,3-propanediol enantiomers which are, in turn, accessed in good yields via a Sharpless asymmetric epoxidative resolution. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00074-9

文献信息

• Catalysts
  申请人：Hems Patrick William

  公开号：US20070066850A1

  公开（公告）日：2007-03-22

  Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group (8) transition metal compound a chiral phosphine and a chiral diamine of formula (1) in which R 1 , R 2 R 3 or R 4 are independently hydrogen, a saturated or unsaturated alkyl, or cycloalkyl group, an aryl group, a urethane or sulphonyl group and R 5 , R 6 , R 7 or R 8 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, at least one of R 1 , R 2 , R 3 or R 4 is hydrogen and A is a linking group comprising one or two substituted or unsubstituted carbon atoms.

  本文描述了用于不对称氢化反应的催化剂，包括式（1）中的手性膦和手性二胺与8族过渡金属化合物的反应产物，其中R1、R2、R3或R4独立地为氢、饱和或不饱和烷基、环烷基、芳基、脲基或磺酰基，R5、R6、R7或R8独立地为氢、饱和或不饱和烷基或环烷基、或芳基，其中至少有一个为氢，A为含有一个或两个取代或未取代碳原子的连接基。
• CATALYSTS
  申请人：Hems William Patrick

  公开号：US20100197976A1

  公开（公告）日：2010-08-05

  Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group 8 transition metal compound a chiral phosphine and a chiral diamine of formula (I) in which R 1 , R 2 , R 3 and R 4 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, an aryl group or a urethane or sulphonyl group and R 5 , R 6 , R 7 and R 8 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, at least one of R 1 , R 2 , R 3 and R 4 is hydrogen and A is a linking group comprising one or two substituted or unsubstituted carbon atoms.

  本文描述了适用于不对称氢化反应的催化剂，其包括由8族过渡金属化合物、手性膦和手性式(I)的二胺的反应产物。其中，R1、R2、R3和R4独立地为氢、饱和或不饱和的烷基或环烷基、芳基或脲或磺酰基；R5、R6、R7和R8独立地为氢、饱和或不饱和的烷基或环烷基或芳基；R1、R2、R3和R4中至少一个为氢；A为一个包含一个或两个取代或未取代碳原子的连接基团。
• Biphosphine ruthenium complexes with chiral diamine ligands as catalysts
  申请人：Johnson Matthey PLC

  公开号：EP1849792A1

  公开（公告）日：2007-10-31

  A chiral catalyst suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a ruthenium compound, a chiral bis(phosphine) and a chiral diamine of formula (I) in which R1, R2, R3 or R4 are independently hydrogen, a saturated or unsaturated alkyl, or cycloalkyl group, an aryl group, a urethane or sulphonyl group, R1 and R2 may be linked or R3 and R4 may be linked so as to form a 4 to 7-membered ring structure incorporating the nitrogen atom, at least one of R1, R2, R3 or R4 is hydrogen; A is a linking group comprising one or two substituted or unsubstituted carbon atoms; R5, R6, R7 or R8 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, wherein one or more of R5, R6 R7 or R8 forms one or more ring structures with linking group A, and the chiral bis(phosphine) is selected from the group consisting of BINAP, DUPHOS, BIPHEP, TMBTP, BITIANAP, BIBFUP, bppm, CARBOPHOS, JOSIPHOS, BPE, DEGPHOS, DIOP, BIPNOR, PHANEPHOS, SELKE AND BINAPAN.

  描述了一种适用于不对称氢化反应的手性催化剂，该催化剂由钌化合物、手性双膦和手性二胺的反应产物组成，其式为(I) 其中 R1、R2、R3 或 R4 独立地为氢、饱和或不饱和烷基或环烷基、芳基、氨基甲酸酯或磺酰基，R1 和 R2 可连接或 R3 和 R4 可连接以形成包含氮原子的 4 至 7 元环结构，R1、R2、R3 或 R4 中至少有一个为氢；A 为包含一个或两个取代或未取代碳原子的连接基团；R5、R6、R7 或 R8 独立地为氢、饱和或不饱和烷基或环烷基或芳基，其中一个或多个 R5、R6、R7 或 R8 与连接基团 A 形成一个或多个环结构、手性双膦选自 BINAP、DUPHOS、BIPHEP、TMBTP、BITIANAP、BIBFUP、bppm、CARBOPHOS、JOSIPHOS、BPE、DEGPHOS、DIOP、BIPNOR、PHANEPHOS、SELKE 和 BINAPAN 所组成的组。
• [EN] BIPHOSPHINE RUTHENIUM COMPLEXES WITH CHIRAL DIAMINE LIGANDS AS CATALYSTS<br/>[FR] CATALYSEURS
  申请人：JOHNSON MATTHEY PLC

  公开号：WO2005007662A3

  公开（公告）日：2005-03-24
• US8039675B2
  申请人：——

  公开号：US8039675B2

  公开（公告）日：2011-10-18