8-(diphenyl-phosphinoyl)-10,10-dimethyl-5-(1-oxy-pyridin-2-yl)-6-aza-tricyclo[7.1.1.0(2,7)]undeca-2(7),3,5-triene 6-oxide | 1092577-39-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-(diphenyl-phosphinoyl)-10,10-dimethyl-5-(1-oxy-pyridin-2-yl)-6-aza-tricyclo[7.1.1.0(2,7)]undeca-2(7),3,5-triene 6-oxide
• CAS: 1092577-39-3
• 化学式: C₂₉H₂₇N₂O₃P
• 分子量: 482.519
• InChiKey: IKCWCTYJWWVQNV-FMGHJNRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.82
• 重原子数：
  35.0
• 可旋转键数：
  4.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  70.95
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  8-(diphenyl-phosphinoyl)-10,10-dimethyl-5-pyridin-2-yl-6-aza-tricyclo[7.1.1.0(2,7)]undeca-2(7),3,5-triene 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以84%的产率得到8-(diphenyl-phosphinoyl)-10,10-dimethyl-5-(1-oxy-pyridin-2-yl)-6-aza-tricyclo[7.1.1.0(2,7)]undeca-2(7),3,5-triene 6-oxide
  参考文献：
  名称：

  Enantioselective Strecker-type reaction of phosphinoyl ketimines catalyzed by a chiral Zr-bipyridyldiol catalyst

  摘要：

  An enantioselective Strecker reaction of N-diphenylphosphinoyl ketimines with TMSCN employing a chiral zirconium complex formed from chiral bipyridyl diol 1 as catalyst is described. The catalytic efficiency of chiral ligand 1 with other Lewis acids was also explored. Higher yields (50-85%) with moderate to good enantioselectivities (30-80%) were achieved for a variety of N-diphenylphosphinoyl ketimines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.09.011
• 作为试剂：
  描述：

  三甲基氰硅烷 、 E-P,P-二苯基-N-(1-苯基亚乙基)膦酰胺 在 8-(diphenyl-phosphinoyl)-10,10-dimethyl-5-(1-oxy-pyridin-2-yl)-6-aza-tricyclo[7.1.1.0(2,7)]undeca-2(7),3,5-triene 6-oxide 、 zirconium(IV) tert-butoxide 作用下， 以 甲苯 为溶剂， 反应 40.0h， 生成 N-(1-cyano-1-phenylethyl)-P,P-diphenylphosphinamide
  参考文献：
  名称：

  Enantioselective Strecker-type reaction of phosphinoyl ketimines catalyzed by a chiral Zr-bipyridyldiol catalyst

  摘要：

  An enantioselective Strecker reaction of N-diphenylphosphinoyl ketimines with TMSCN employing a chiral zirconium complex formed from chiral bipyridyl diol 1 as catalyst is described. The catalytic efficiency of chiral ligand 1 with other Lewis acids was also explored. Higher yields (50-85%) with moderate to good enantioselectivities (30-80%) were achieved for a variety of N-diphenylphosphinoyl ketimines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.09.011