5-methyl-3-[(3'-coumarinyl)]-7H-[1,3]-thiazolo-[3,2-a]-pyrimidine-7-one | 1233880-54-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 5-methyl-3-[(3'-coumarinyl)]-7H-[1,3]-thiazolo-[3,2-a]-pyrimidine-7-one
• CAS: 1233880-54-0
• 化学式: C₁₆H₁₀N₂O₃S
• 分子量: 310.333
• InChiKey: CVCYFAGPTPVFOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  22.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  64.58
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  甲基硫脲嘧啶 、 3-(溴乙酰基)香豆素 反应 0.02h， 以90%的产率得到5-methyl-3-[(3'-coumarinyl)]-7H-[1,3]-thiazolo-[3,2-a]-pyrimidine-7-one
  参考文献：
  名称：

  Synthesis and biological evaluation of some new coumarinyl thiazolopyrimidinones

  摘要：

  Two new series of coumarin linked, linear and angularly fused thiazolo-[3,2-a]-pyrimidinones have been synthesized from 3-bromoacetyl coumarins by azole and azine approaches. Regioisomeric 5H and 7H thiazolo-[3,2-a]-pyrimidinones have been clearly distinguished by their IR and UV fluorescence spectral data. All the compounds have been characterized by analytical and spectroscopic methods. Rate and yield enhancements have been achieved using microwave irradiation. The results of in vivo diuretic activity indicate that substituents on coumarin do not enhance the activity. In vitro antimicrobial activities have shown that the compounds are specifically active against Gram-positive but are inactive against Gram-negative bacterial strains. Moderate fungal activity was observed against Candida albicans and Penicillium chrysogenum and all the compounds were found to be inactive against Aspergillus niger.

  DOI：

  10.1080/17415990903569544