(2E,6E)-10,11-epoxyfarnesyl 2-diazo-3,3,3-trifluoropropionate | 111836-05-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2E,6E)-10,11-epoxyfarnesyl 2-diazo-3,3,3-trifluoropropionate
• CAS: 111836-05-6
• 化学式: C₁₈H₂₅F₃N₂O₃
• 分子量: 374.403
• InChiKey: TUQFYCOLSSMRLI-WAAHFECUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.39
• 重原子数：
  26.0
• 可旋转键数：
  9.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  75.23
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2E,6E)-10,11-epoxyfarnesyl 2-diazo-3,3,3-trifluoropropionate 以 甲醇 为溶剂， 生成 3,3,3-Trifluoro-2-methoxy-propionic acid (2E,6E)-9-(3,3-dimethyl-oxiranyl)-3,7-dimethyl-nona-2,6-dienyl ester
  参考文献：
  名称：

  Synthesis of Radiolabeled Juvenile Hormone Analogs and Chiral Homologs

  摘要：

  AbstractRadiolabeled juvenile hormone (JHs) and labeled JH derivatives are required for the study of JH metabolism and JH‐protein interactions as well as JH radioimmunoassay in insects. The progress in the synthesis of these labeled compounds for the last five years is reviewed, including the preparation of photoaffinity labels, enantiomerically enriched JH I and JH II with 3H labels, and radioiodinated analogs of JH I, methoprene and phenoxyphenyl ether insect growth regulators (IGRs). Experimental details are given for the efficient synthesis of two 3H‐labeled photoactivatable JH analogs, EFDA and EFTP, their photolysis in methanol, and their competitive binding assays performed on the Manduca sexta JH binding proteins (JHBP).

  DOI：

  10.1002/bscb.19860950913
• 作为产物：
  描述：

  11-hydroxy-3,7,11-trimethyl-10-oxododeca-2,6-dienylacetate 在 吡啶 、 sodium tetrahydroborate 、 potassium carbonate 、 三乙胺 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 反应 51.0h， 生成 (2E,6E)-10,11-epoxyfarnesyl 2-diazo-3,3,3-trifluoropropionate
  参考文献：
  名称：

  Synthesis of Radiolabeled Juvenile Hormone Analogs and Chiral Homologs

  摘要：

  AbstractRadiolabeled juvenile hormone (JHs) and labeled JH derivatives are required for the study of JH metabolism and JH‐protein interactions as well as JH radioimmunoassay in insects. The progress in the synthesis of these labeled compounds for the last five years is reviewed, including the preparation of photoaffinity labels, enantiomerically enriched JH I and JH II with 3H labels, and radioiodinated analogs of JH I, methoprene and phenoxyphenyl ether insect growth regulators (IGRs). Experimental details are given for the efficient synthesis of two 3H‐labeled photoactivatable JH analogs, EFDA and EFTP, their photolysis in methanol, and their competitive binding assays performed on the Manduca sexta JH binding proteins (JHBP).

  DOI：

  10.1002/bscb.19860950913