Longispinogenin-triacetat | 1721-61-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Longispinogenin-triacetat
• 英文别名: [(4aS,5S,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,10-diacetyloxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicen-4a-yl]methyl acetate
• CAS: 1721-61-5
• 化学式: C₃₆H₅₆O₆
• 分子量: 584.837
• InChiKey: PDSQZLWIMADWQX-UFPXGYACSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Longispinogenin-triacetat 在 selenium(IV) oxide 、 溶剂黄146 作用下， 生成 Acetic acid (4aS,5S,6aS,6bS,8aR,10S,12aS)-10-acetoxy-4a-acetoxymethyl-2,2,6a,6b,9,9,12a-heptamethyl-1,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14-octadecahydro-picen-5-yl ester
  参考文献：
  名称：

  Pyrek,J.S., Polish Journal of Chemistry, 1979, vol. 53, p. 2465 - 2490

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 Longispinogenin-triacetat
  参考文献：
  名称：

  Carrageenan Gel and Aberrant Crypt Foci in the Colon of Conventional and Human Flora-Associated Rats

  摘要：

  Carrageenans (CAR) are sulfated polymers from seaweed used as gelling agents in foods. Chemical carcinogen induction of tumors in the colon of rats is enhanced by CAR. We speculated that gut microflora is involved in this effect. We thus studied the initiating and promoting effects of undegraded CAR-kappa (345,000 mol wt) in conventional rats and in germ-free rats associated with a human fecal flora. The initiating effect of CAR was studied by scoring aberrant crypt foci (ACF) in the colon of Fischer 344 rats given CAR (10% in water). The promoting effect of CAR was studied by comparing the multiplicity of ACF (number of crypts/focus) in vats receiving pure water or CAR (0.25% and 2.5% in water) for 100 days, starting 7 days after azoxymethane initiation (1 dose of 20 mg/kg ip). Duplicate studies were conducted in conventional rats and in human flora-associated rats maintained in isolators. Results show that CAR did not initiate ACF. In conventional rats, the 2.5% CAR gel promoted the growth of ACF: 2.98 +/- 0.29 and 3.44 +/- 0.48 crypts/ACF in control and treated vats, respectively (p < 0.02). The 0.25% CAR gel did not promote ACF. CAR can thus enhance intestinal tumors in this vat model, bur only at a high dose level. In contrast, we did not observe any promoting effect of the administration of the 2.5% CAR gel in human flora-associated Fats: 2.81 +/- 0.18 and 2.78 +/- 0.38 crypts/ACF in control and treated rats, respectively (p = 0.80). The specific microflora of rats, but not the human gut flora, might be involved in colon tumor enhancement by CAR.

  DOI：

  10.1207/s15327914nc372_12

文献信息

• Steroids. LIV.¹ Synthesis of 19-Nov-17α-ethynyltestosterone and 19-Nor-17α-methyltestosterone²
  作者：Carl Djerassi、L. Miramontes、G. Rosenkranz、Franz Sondheimer

  DOI：10.1021/ja01645a010

  日期：1954.8
• Triterpenoids from bupleurum falcatum L.—I
  作者：Tokuo Kubota、F. Tonami、H. Hinoh

  DOI：10.1016/s0040-4020(01)92301-4

  日期：1967.1