4'',6''-O-ethylidenemaltotriose | 144152-01-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4'',6''-O-ethylidenemaltotriose
• CAS: 144152-01-2；144178-94-9
• 化学式: C₂₀H₃₄O₁₆
• 分子量: 530.48
• InChiKey: ROFBVNNUCKDULK-UWIXSKMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.16
• 重原子数：
  36.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  246.68
• 氢给体数：
  9.0
• 氢受体数：
  16.0

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 4'',6''-O-ethylidenemaltotriose 在 吡啶 作用下， 以88%的产率得到4'',6''-O-ethylidenemaltotriose-1,2,3,6,2',3',6',2",3"-nona-acetate
  参考文献：
  名称：

  Studies of the interaction of the maltose-binding protein of Escherichia coli, a closed-groove binder, with 4,6-O-ethylidenemalto-oligosaccharides (dp 2–5) and its regioselective labelling with 3-azibutyl 1-thio-α-(6-3H)maltoside

  摘要：

  Four malto-oligosaccharides (dp 2-5), each with a 4,6-O-ethylidene group on the glucosyl unit at the non-reducing terminus, were synthesised and used to prove that the maltose-binding protein (MBP) of E. coli is a closed-groove binder. Alpha-D-glucosylation of 3-azibutyl 1-thio-alpha-D-(6-H-3)glucopyranoside yielded a H-3-labelled, photolabile 1-thiomaltoside derivative that was used to chemically modify the binding site of MBP. The H-3-labelled peptide containing 83% of the total radioactivity, which was isolated after tryptic cleavage of the modified MBP and sequenced, is part of the closed end of the MBP groove.

  DOI：

  10.1016/s0008-6215(00)90995-9
• 作为产物：
  描述：

  maltotriose 、 二甲氧基乙烷 在 对甲苯磺酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 以50.5%的产率得到4'',6''-O-ethylidenemaltotriose
  参考文献：
  名称：

  Studies of the interaction of the maltose-binding protein of Escherichia coli, a closed-groove binder, with 4,6-O-ethylidenemalto-oligosaccharides (dp 2–5) and its regioselective labelling with 3-azibutyl 1-thio-α-(6-3H)maltoside

  摘要：

  Four malto-oligosaccharides (dp 2-5), each with a 4,6-O-ethylidene group on the glucosyl unit at the non-reducing terminus, were synthesised and used to prove that the maltose-binding protein (MBP) of E. coli is a closed-groove binder. Alpha-D-glucosylation of 3-azibutyl 1-thio-alpha-D-(6-H-3)glucopyranoside yielded a H-3-labelled, photolabile 1-thiomaltoside derivative that was used to chemically modify the binding site of MBP. The H-3-labelled peptide containing 83% of the total radioactivity, which was isolated after tryptic cleavage of the modified MBP and sequenced, is part of the closed end of the MBP groove.

  DOI：

  10.1016/s0008-6215(00)90995-9