(1,2:4,5)-di-O-isopropylidene-scyllo-inositol | 261617-68-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1,2:4,5)-di-O-isopropylidene-scyllo-inositol
• CAS: 261617-68-9
• 化学式: C₁₂H₂₀O₆
• 分子量: 260.287
• InChiKey: LDPFQVWIUACVFE-UVJOLXELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.24
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77.38
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (1,2:4,5)-di-O-isopropylidene-scyllo-inositol 在 三甲基溴硅烷 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 sodium salt of scyllo-inositol 1,4-biphosphate
  参考文献：
  名称：

  Synthesis of all possible regioisomers of scyllo-Inositol phosphate

  摘要：

  scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All possible 12 regioisomers of scyllo-inositol phosphate were synthesized for the first time via a scyllo-inositol benzoate intermediate, which was derived from a myo-inositol derivative. The stereoinversion of myo-inositol into scyllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis-diol. The requisite intermediates, scyllo-inositol benzoates were obtained by benzoyl migration or random benzoylation, and phosphorylated to give scyllo-IPn. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00183-2
• 作为产物：
  描述：

  DL-1-O-mono-benzoyl-(2,3:5,6)-di-O-isopropylidene-scyllo-inositol 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 (1,2:4,5)-di-O-isopropylidene-scyllo-inositol
  参考文献：
  名称：

  Synthesis of all possible regioisomers of scyllo-Inositol phosphate

  摘要：

  scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All possible 12 regioisomers of scyllo-inositol phosphate were synthesized for the first time via a scyllo-inositol benzoate intermediate, which was derived from a myo-inositol derivative. The stereoinversion of myo-inositol into scyllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis-diol. The requisite intermediates, scyllo-inositol benzoates were obtained by benzoyl migration or random benzoylation, and phosphorylated to give scyllo-IPn. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(99)00183-2

文献信息

• Inositol-based molecular transporters and processes for the preparation thereof
  申请人：Chung Sung-Kee

  公开号：US20060280796A1

  公开（公告）日：2006-12-14

  Inositol derivatives in accordance with the present invention are effective in significantly enhancing the transportation of various therapeutic molecules across a biological membrane, which may include the plasma membrane, nuclear membrane or blood-brain barrier.

  根据本发明，肌醇衍生物能够显著增强各种治疗分子通过生物膜的传输，这些生物膜可能包括质膜、核膜或血脑屏障。
• US7589072B2
  申请人：——

  公开号：US7589072B2

  公开（公告）日：2009-09-15