1,2-O-isopropylidene-β-D-threofuranose | 37669-00-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-O-isopropylidene-β-D-threofuranose
• 英文别名: 1,2-isopropylidene-β-D-threofuranose；O¹,O²-isopropylidene-β-D-threofuranose；O¹,O²-Isopropyliden-β-D-threofuranose；O¹,O²-Isopropyliden-β-D-threo-furanose；1,2-O-Isopropyliden-β-D-threo-furanose；1,2-O-Isopropyliden-β-D-threofuranose；(3aS,6R,6aS)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol
• CAS: 37669-00-4
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: GCDHRQSHVCHCIJ-SRQIZXRXSA-N

物化性质

• 沸点：
  255.8±35.0 °C(Predicted)
• 密度：
  1.218±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.14
• 重原子数：
  11.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1,2-O-isopropylidene-β-D-threofuranose 在 吡啶 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 118.0h， 生成 3-O-benzoyl-1,2-O-isopropylidene-α-L-erythrofuranose
  参考文献：
  名称：

  Jary, Jiri; Masojidkova, Marie; Kozak, Ivan, Collection of Czechoslovak Chemical Communications, 1980, vol. 45, # 12, p. 3378 - 3391

  摘要：

  DOI：
• 作为产物：
  描述：

  O2,O3-((Ξ)-benzyliden)-D-arabitol 在 sodium periodate 作用下， 生成 1,2-O-isopropylidene-β-D-threofuranose
  参考文献：
  名称：

  The Isomeric 1,3- and 2,3-Benzylidene-D-arabitols

  摘要：

  DOI：

  10.1021/ja01249a001

文献信息

• Perceptions of Depression in a Community Sample in Dubai
  作者：Sultana O. Y. Sulaiman、Dinesh Bhugra、Padmal de Silva

  DOI：10.1177/136346150103800204

  日期：2001.6

  Although words describing depression may not exist across all cultures, the symptoms of depression do. In a study of the Arab community in Dubai, we conducted four focus groups, two each with males and females, to identify the terms and descriptions people use for depression, what symptoms they associate with it, their views on its causes, and their strategies for coping with it. All individuals knew someone who met the description of depression. The key symptoms of depression identified included: social withdrawal, feeling afraid, irritability, loss of sleep, loss of appetite, sadness, crying, excessive thinking, feeling bored and loss of interest in sex. Causes of depression identified included: stresses in the family and in the society, relationships, lack of support, marital conflicts, and problems with children. The most effective coping strategy identified was that of going to religious places and talking to religious professionals.

  尽管描述抑郁症的词语可能并非所有文化都存在，但抑郁症的症状却存在。在迪拜的阿拉伯社区进行的一项研究中，我们开展了四个焦点小组讨论，分别是两个男性和两个女性，以确定人们用于描述抑郁症的术语和描述，他们将哪些症状与之相关联，他们对其原因的看法，以及应对它的策略。所有参与者都认识符合抑郁症描述的人。确定的抑郁症主要症状包括：社交退缩、感到害怕、易怒、失眠、食欲不振、悲伤、哭泣、过度思考、感到无聊和对性的兴趣丧失。确定的抑郁症原因包括：家庭和社会压力、人际关系、缺乏支持、婚姻冲突以及与子女的问题。确定的最有效应对策略是去宗教场所并与宗教专业人士交谈。
• Fluorinated Analogues to the Pentuloses of the Pentose Phosphate Pathway
  作者：Lukas Scheibelberger、Toda Stankovic、Kaja Liepert、Andreas Kienzle、Eva‐Maria Patronas、Theresa Balber、Markus Mitterhauser、Arvand Haschemi、Katharina Pallitsch

  DOI：10.1002/ejoc.202300339

  日期：2023.8.14

  Fluorinated carbohydrates are valuable tools for enzymological studies due to their increased metabolic stability compared to their non‐fluorinated analogues. Replacing different hydroxyl groups within the same monosaccharide by fluorine allows to influence a wide range of sugar–receptor interactions and enzymatic transformations. In the past, this principle was frequently used to study the metabolism of highly abundant carbohydrates, while the metabolic fate of rare sugars is still poorly studied. Rare sugars, however, are key intermediates of many metabolic routes, such as the pentose phosphate pathway (PPP). Here we present the design and purely chemical synthesis of a set of three deoxyfluorinated analogues of the rare sugars d‐xylulose and d‐ribulose: 1‐deoxy‐1‐fluoro‐d‐ribulose (1DFRu), 3‐deoxy‐3‐fluoro‐d‐ribulose (3DFRu) and 3‐deoxy‐3‐fluoro‐d‐xylulose (3DFXu). Together with a designed set of potential late‐stage radio‐fluorination precursors, they have the potential to become useful tools for studies on the complex equilibria of the non‐oxidative PPP.

  摘要与不含氟的类似物相比，含氟碳水化合物具有更高的代谢稳定性，因此是酶学研究的重要工具。用氟取代同一单糖中的不同羟基可以影响糖与受体之间的广泛相互作用和酶促转化。过去，这一原理经常被用于研究高含量碳水化合物的代谢，而对稀有糖类代谢命运的研究还很少。然而，稀有糖是磷酸戊糖途径（PPP）等许多代谢途径的关键中间产物。在此，我们介绍了一组稀有糖类 d-xylulose 和 d-ribulose 的三种脱氧氟化类似物的设计和纯化学合成：1-deoxy-1-fluoro-d-ribulose (1DFRu)、3-deoxy-3-fluoro-d-ribulose (3DFRu) 和 3-deoxy-3-fluoro-d-xylulose (3DFXu)。它们与一套设计好的潜在后期放射性氟化前体一起，有可能成为研究非氧化型 PPP 复杂平衡的有用工具。
• Smith III, Amos B.; Sulikowski, Gary A.; Sulikowski, Michelle M., Journal of the American Chemical Society, 1992, vol. 114, # 7, p. 2567 - 2576
  作者：Smith III, Amos B.、Sulikowski, Gary A.、Sulikowski, Michelle M.、Fujirooto, Kataumi

  DOI：——

  日期：——
• Collins, Peter M.; Farnia, Farnoosh, Journal of the Chemical Society. Perkin transactions I, 1985, p. 575 - 582
  作者：Collins, Peter M.、Farnia, Farnoosh

  DOI：——

  日期：——
• Gakhokidze, Zhurnal Obshchei Khimii, 1945, vol. 15, p. 530
  作者：Gakhokidze

  DOI：——

  日期：——