genipin | 860379-65-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: genipin
• 英文别名: Methyl 1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
• CAS: 860379-65-3
• 化学式: C₁₁H₁₄O₅
• 分子量: 226.229
• InChiKey: AZKVWQKMDGGDSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  genipin 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 生成 methyl 1-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
  参考文献：
  名称：

  WO2023/102652

  摘要：

  公开号：
• 作为产物：
  描述：

  geniposide 在 β-glucosidase 作用下， 生成 genipin
  参考文献：
  名称：

  CN116514764

  摘要：

  公开号：

文献信息

• [EN] QUINOLINYL-PYRAZINE-CARBOXAMIDE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE QUINOLINYL-PYRAZINE-CARBOXAMIDE ET UTILISATIONS ASSOCIÉES
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2020132459A1

  公开（公告）日：2020-06-25

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinolinyl-pyrazine-carboxamide (or similar) structure which function as activators of the cholesterol biosynthesis pathway within cancer cells and/or immune cells, which function as activators of the cell cycle regulation pathway within cancer cells and/or immune cells, and which function as up-regulators of HMGCS1 protein expression within cancer cells and/or immune cells, and which function as effective therapeutic agents for treating, ameliorating, and preventing various forms of cancer and other inflammatory disease.

  这项发明属于药物化学领域。具体来说，该发明涉及一类新型小分子，其具有喹啉基-吡嗪-羧酰胺（或类似）结构，其在癌细胞和/或免疫细胞内作为胆固醇生物合成途径的激活剂，作为癌细胞和/或免疫细胞内细胞周期调控途径的激活剂，作为癌细胞和/或免疫细胞内HMGCS1蛋白表达的上调剂，以及作为治疗、改善和预防各种癌症和其他炎症性疾病的有效治疗剂。
• [EN] SEMI-PERMANENT TATTOOS<br/>[FR] TATOUAGES SEMI-PERMANENTS
  申请人：INKBOX INK INC

  公开号：WO2022036113A1

  公开（公告）日：2022-02-17

  The present disclosure relates to semi-permanent tattoos, for example, compositions comprising semi-permanent colorants and semi-permanent colorant precursors that include derivatives of genipin and lawsone. In some embodiments, the composition comprises: a semi-permanent colorant present in an amount of about 10% to about 20% w/w of the composition; a solvent present in an amount of about 65% to about 80% w/w of the composition; and a thickening agent present in an amount of 0.01% to about 0.3% w/w of the composition. In some embodiments, the composition further includes one or more of a film-forming agent, a humectant, and a preservative.

  本公开涉及半永久纹身，例如，包括半永久颜料和半永久颜料前体的组合物，其中包括龙胆素和罗孚酮的衍生物。在某些实施例中，组合物包括：半永久颜料，其占组合物质量的约10％至约20％；溶剂，其占组合物质量的约65％至约80％；以及增稠剂，其占组合物质量的0.01％至约0.3％。在某些实施例中，组合物进一步包括一种或多种膜形成剂、保湿剂和防腐剂。
• Solvent-tunable dipeptide-based nanostructures with enhanced optical-to-electrical transduction
  作者：Huimin Xue、Xianbao Li、Keqing Wang、Wei Cui、Jie Zhao、Jinbo Fei、Junbai Li

  DOI：10.1039/c9cc07520h

  日期：——

  We explore a facile approach to construct solvent-tunable dipeptide-based nanostructures, which exhibit a structure-dependent and remarkably enhanced optoelectronic response.

  我们探索了一种简便的方法来构建可溶剂调控的二肽基纳米结构，这些结构表现出结构依赖性和显著增强的光电响应。
• Product of crosslinked material and method for producing the same
  申请人：SpinPlant GmbH

  公开号：EP2458043A1

  公开（公告）日：2012-05-30

  The invention relates to a method for producing a nanofiber-based product, comprising the steps of providing a carrier material solution comprising a carrier material, and of bringing the carrier material in contact with a collector by electrospinning the carrier material solution out of a spinning device. Thereby, the collector has a first electrical polarity and the spinning device has a second electrical polarity being opposite to the first polarity. According to the invention, the carrier material essentially consists of a polymer being - at least after having contacted the collector - chemically crosslinked with the residue of a crosslinker and/or embedded in a polymer, which polymer is formed by the crosslinker. The crosslinker is chosen from the group consisting of glutaraldehyde, carbodiimide, genipin, photoreactive diazines and a compound according to the general formula (1) wherein wherein R1 is a single bond between the adjacent carbon atoms, or a carbohydrate chain having 1 to 10 carbon atoms and optionally bearing a hydroxy group, the carbohydrate chain being saturated, unsaturated or polyunsaturated, and wherein R2, R3, R4 and R5 are independently from each other a hydrogen; a carbohydrate chain having 1 to 10 carbon atoms and optionally bearing a hydroxy group, the carbohydrate chain being saturated, unsaturated or polyunsaturated; a hydroxy group; or a sulfhydryl group; with the provision that the compound bears at least two hydroxy groups, or two sulfhydryl groups, or one hydroxy group and one sulfhydryl group. The invention further relates to an according product and its use.

  本发明涉及一种生产纳米纤维产品的方法，包括以下步骤：提供由载体材料组成的载体材料溶液；通过从纺丝装置中电纺出载体材料溶液，使载体材料与收集器接触。因此，收集器具有第一极性，而纺丝装置具有与第一极性相反的第二极性。根据本发明，载体材料主要由聚合物组成，该聚合物至少在与收集器接触后与交联剂的残留物发生化学交联和/或嵌入聚合物中，该聚合物由交联剂形成。交联剂选自戊二醛、碳化二亚胺、基因平、光活性重氮和通式 (1) 所示化合物组成的组中 其中 R1 是相邻碳原子之间的单键，或具有 1 至 10 个碳原子并可选择带有羟基的碳水化合物链，该碳水化合物链为饱和、不饱和或多不饱和，且 R2、R3、R4 和 R5 相互独立地为氢；具有 1 至 10 个碳原子并可选带有羟基的碳水化合物链，该碳水化合物链为饱和、不饱和或多不饱和；羟基；或巯基；规定该化合物至少带有两个羟基，或两个巯基，或一个羟基和一个巯基。本发明还涉及一种相应的产品及其用途。
• CROSSLINKER COMPRISING GENIPIN FOR USE IN PREPARATION OF SENSING FILM OR DIFFUSION CONTROL FILM OF ELECTROCHEMICAL SENSOR
  申请人：i-Sens, Inc.

  公开号：EP3805304A1

  公开（公告）日：2021-04-14

  The present disclosure relates to a composition for a crosslinking agent for the preparation of a sensing layer or a diffusion control layer of an electrochemical biosensor comprising genipin or a derivative thereof, in which due to the properties of genipin that can be extracted and used from plants, not only it has high biocompatibility compared to conventional crosslinking agents with high toxicity, but also it can easily confirm the progress of the reaction by measuring UV or measuring the amount of amine groups present when reacting with a compound having an amine group, for example, an electron transport medium, and additionally, it has the advantage of suppressing a rapid decrease in sensor life due to high concentration of glucose while maintaining an appropriate sensitivity to glucose.

  本公开涉及一种用于制备电化学生物传感器的传感层或扩散控制层的交联剂组合物，该组合物由基因素或其衍生物组成，其中由于基因素可以从植物中提取和使用的特性，与具有高毒性的传统交联剂相比，它不仅具有高生物相容性、此外，它还具有在保持对葡萄糖的适当灵敏度的同时，抑制因葡萄糖浓度过高而导致传感器寿命迅速缩短的优点。