2-hydroxy-1,7-heptanedioic acid | 87043-79-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-hydroxy-1,7-heptanedioic acid
• 英文别名: 2-hydroxyheptanedfioic acid；2-hydroxyheptanedioic acid；2-hydroxypimelic acid；α-Hydroxy-pimelinsaeure；2-Hydroxy-heptandisaeure；2-Hydroxy-pimelinsaeure；hydroxypimelic acid
• CAS: 87043-79-6
• 化学式: C₇H₁₂O₅
• 分子量: 176.169
• InChiKey: LYFNCKPMTCSLBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-hydroxy-1,7-heptanedioic acid 在 1H-1,2,4-三唑 、 sodium hydroxide 、 氯化亚砜 、 羟胺 、 对甲苯磺酸 、 溶剂黄146 、 N,N-二甲基甲酰胺 、 silver(l) oxide 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 5-(6-Diazo-5-oxo-hexyl)-2,2-dimethyl-[1,3]dioxolan-4-one
  参考文献：
  名称：

  ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence

  摘要：

  A series of omega-alkoxy ethers were prepared with variation of the length of the aliphatic chain of suberoylanilide hydroxamic acid (SAHA, vorinostat). Eight carbon long chain analogues showed the best activity, among which several substituted benzyl ether derivatives exhibited inhibitory activity on HDAC comparable to SAHA, and antiproliferative activity on three human cell lines (NB4, H460, and HCT-116) better than SAHA. However, no significant difference in antiproliferative activity was observed between two enantiomers bearing the benzyl ether moiety. (C) 2007 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2007.09.014
• 作为产物：
  描述：

  DL-2-氨基庚二酸 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 2-hydroxy-1,7-heptanedioic acid
  参考文献：
  名称：

  WO2008/110583

  摘要：

  公开号：

文献信息

• Oxidative transformations of some pyrimidine derivatives into oxazolidine derivatives
  作者：Jiří Křepelka、Vladimír Pouzar、Jiří Schlanger、Jiří Holubek、Jiří Körbl、Fedir Jančik、Rudolf Kotva

  DOI：10.1135/cccc19831212

  日期：——

  The action of dilute hydrogen peroxide in aqueous alkaline solutions on compounds I-VI and XX produced derivatives of 2-iminooxazolidine-4-one, VII-XI and XXI. Their structures were demonstrated by spectral comparison with hydantoin derivatives XXII, XXIV and XXV, which were prepared from 2-aminoalkanedioic acids XXVIII, XXX and XXXI by reaction with potassium cyanate, followed by ring closure induced by a mineral acid. The structure of compound X was revealed by basic hydrolysis to 2-hydroxy-1,7-heptanedioic acid (XXVII) and by conversion of the latter, in an acid medium, into a derivative of oxazolidine-2,4-dione, XXIX. To elucidate the probable mechanism of the oxidative transformation, compound IV was converted by oxidation in an acid medium into the 5-hydroxy derivative XXXII. Exposure of the latter to an alkaline medium gave compound X. Bromination of acid IV with bromine, or with a mixture of potassium bromide and bromate in an acid solution, afforded the 5-bromo derivative XXXIV. Analogously, reaction of the acid IV with a mixture of hydrogen peroxide and hydrochloric acid gave the 5-chloro derivative XXXV. Boiling the compound XXXIV in aqueous sodium hydroxide led to the acid IV and a smaller amount of compound X. Reaction of the compound X with morpholine yielded the morpholine analogue XXXVI. In the screening for antineoplastic activity, compounds XXXII and XXXVI showed weak antitumors effects with some types of experimental tumors. Compound X was quite ineffective in the general pharmacological screening.

  在水性碱溶液中稀释的过氧化氢对化合物I-VI和XX的作用产生了2-亚胺氧氮杂环-4-酮衍生物VII-XI和XXI。它们的结构通过与由2-氨基脂肪酸XXVIII、XXX和XXXI与氰酸钾反应后由矿酸诱导的环合反应制备的脲衍生物XXII、XXIV和XXV的光谱比较得到证明。化合物X的结构通过碱性水解成2-羟基-1,7-庚二酸（XXVII）和后者在酸性介质中转化为2,4-二酮-亚胺氧氮杂环衍生物XXIX来揭示。为了阐明氧化转化的可能机制，化合物IV在酸性介质中氧化成5-羟基衍生物XXXII。将后者暴露在碱性介质中得到化合物X。将酸性IV与溴或在酸性溶液中的溴化钾和溴酸混合物反应得到5-溴衍生物XXXIV。类似地，将酸性IV与过氧化氢和盐酸混合物反应得到5-氯衍生物XXXV。将化合物XXXIV在水性氢氧化钠中加热可得到酸性IV和少量化合物X。将化合物X与吗啡啶反应可得到吗啡啶类似物XXXVI。在抗肿瘤活性筛选中，化合物XXXII和XXXVI对某些实验性肿瘤表现出微弱的抗肿瘤效果。化合物X在一般药理筛选中效果不佳。
• Coloring composition for color filters containing microencapsulated pigment composed of polyhydroxyalkanoate
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20030203458A1

  公开（公告）日：2003-10-30

  The invention provides coloring composition for color filters making use of a pigment, in which the dispersed state of the pigment is stable without using any surfactant, and so aggregation is hard to occur, and which permits formation of high-definition and high-quality images excellent in color rendition, transparency and contrast, and a simple production process thereof, by which the use of surfactants can be abolished, or the amount of surfactants used can be reduced to a great extent. The coloring composition for color filters is provided by using at least a coloring material obtained by coating at least part of surfaces of pigment particles with polyhydroxyalkanoate, and a dispersion medium for the coloring material.

  该发明提供了一种用于彩色滤光片的染色组合物，其中颜料的分散状态稳定，不需要使用任何表面活性剂，因此聚集很难发生，并且允许形成高清晰度和高质量的图像，具有出色的色彩再现度、透明度和对比度，以及简单的生产过程，通过该过程可以废除表面活性剂的使用，或者大大减少所使用的表面活性剂的数量。通过使用至少一种染色材料，该染色材料通过在颜料颗粒的至少一部分表面上涂覆聚羟基烷酸酯而获得，并且用于染色材料的分散介质。
• Pigment containing ink and production method thereof
  申请人：——

  公开号：US20030203987A1

  公开（公告）日：2003-10-30

  A micro-capsulated pigment containing pigment ink being excellent in density, fineness, transparency, and coloring and color rendering properties required for ink solutions and having excellent dispersibility and dispersion stability with time due to the reduced particle size is provided. At least a color material with at least part of the surfaces of pigment particles covered with polyhydroxyalkanoate, and a medium for dispersion of the color material are used to obtain the pigment ink.

  提供了一种微胶囊化颜料，其中包含颜料油墨，其具有油墨溶液所需的密度、细度、透明度、着色和色彩还原性，由于粒子尺寸的减小，具有优异的分散性和稳定性。使用至少一种颜料材料，其中颜料颗粒的至少一部分表面被聚羟基脂肪酸酯覆盖，以及用于分散颜料材料的介质来获得颜料油墨。
• Electrostatic charge image developing toner, producing method therefor, image forming method and image forming apparatus utilizing the toner, construct and method for making the construct
  申请人：Canon Kabushiki Kaisha

  公开号：US20040259026A1

  公开（公告）日：2004-12-23

  A construct that comprises a base material and a polyhydroxyalkanoate, wherein at least a part of the base material is coated with the polyhydroxyalkanoate, and the polyhydroxyalkanoate comprises a 3-hydroxyalkanoic acid unit other than 3-hydroxypropionic acid unit, 3-hydroxy-n-butyric acid unit, and 3-hydroxy-n-valeric acid unit. In addition, an electrostatic charge image developing toner allows to design the toner characteristics such as chargeability, flowability, stability in time and environmental stability uniform among the toners of different colors. The toner has a small particle size enough for enabling uniform dispersion and being excellent in color saturation and transparency. The toner also shows higher contribution to the environmental security. The toner includes a coloring agent of which at least a part of the surface is covered with polyhydroxyalkanoate (PHA). The toner is produced by dispersing the coloring agent in aqueous medium, then fixing PHA synthesizing enzyme to the coloring agent dispersed in the aqueous medium, then adding 3-hydroxyacyl CoA, and executing a PHA synthesizing reaction to cover at least a part of the surface of the coloring agent with PHA. The toner thus obtained is used for an image forming method.

  一种构造物，包括基材料和聚羟基脂肪酸酯，其中至少一部分基材料被聚羟基脂肪酸酯涂覆，而聚羟基脂肪酸酯包括除了3-羟基丙酸单元、3-羟基-n-丁酸单元和3-羟基-n-戊酸单元之外的3-羟基脂肪酸单元。 此外，静电荷图像开发调色剂可以使调色剂的特性如电荷性、流动性、时间稳定性和环境稳定性在不同颜色的调色剂之间保持一致。调色剂具有足够小的粒径，足以实现均匀分散，并具有优异的色彩饱和度和透明度。调色剂还显示出更高的环境安全贡献。调色剂包括至少部分表面覆盖聚羟基脂肪酸酯（PHA）的着色剂。调色剂通过将着色剂分散在水性介质中，然后将PHA合成酶固定在分散在水性介质中的着色剂上，然后添加3-羟基酰基辅酶A，并执行PHA合成反应，以覆盖至少着色剂表面的一部分与PHA。因此获得的调色剂用于图像形成方法。
• Particles for electrophoresis, a production method thereof and a display using the articles
  申请人：——

  公开号：US20030206330A1

  公开（公告）日：2003-11-06

  Electrophoretic particles for electrophoretic display having excellent dispersibility and dispersion stability with time for insulating media, and being protected against coagulation, settling and the like, a process for production of the electrophoretic particles having high versatility for pigments to be used in response to a full-color display, and an electrophoretic display device using the electrophoretic particles that has an excellent memory property and is highly reliable are provided. The electrophoretic particles are formed using as at least a part of structure a pigment with at least a part of the surface covered with polyhydroxyalkanoate.

  提供了一种具有优异分散性和分散稳定性的电泳显示用电泳粒子，适用于绝缘介质，并受到凝聚、沉淀等的保护。提供了一种用于生产具有高适用性的颜料的电泳粒子的过程，以响应全彩色显示，以及使用电泳粒子的电泳显示装置，具有优异的记忆性能和高可靠性。电泳粒子是使用至少部分表面覆盖聚羟基脂肪酸酯的颜料作为结构的一部分形成的。