(S)-4',7-Dihydroxy-3',8-diprenylflavanone | 59870-65-4

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (S)-4',7-Dihydroxy-3',8-diprenylflavanone
• 英文别名: 7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
• CAS: 59870-65-4
• 化学式: C₂₅H₂₈O₄
• 分子量: 392.5
• InChiKey: CUFAXDWQDQQKFF-UHFFFAOYSA-N

物化性质

• 熔点：
  121-123 °C
• 沸点：
  600.0±55.0 °C(Predicted)
• 密度：
  1.166±0.06 g/cm3(Predicted)
• 溶解度：
  溶于二甲基亚砜
• 物理描述：
  Solid
• 保留指数：
  3424.3

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 储存条件：
  存储条件：2-8°C，密封保存，置于干燥处。

制备方法与用途

生物活性

Glabrol (Compound 1) 是从甘草根的乙醇提取物中分离得到的一种异戊二烯类黄酮，是一种有效且非竞争性的 ACAT（酰基辅酶 A：胆固醇酰基转移酶）抑制剂。其对大鼠肝脏微粒体 ACAT 的 IC50 值为 24.6 μM。

靶点	ratACAT
IC50 (μM)	24.6

体外研究

Glabrol (Compound 1) 可以减少 HepG2 细胞中胆固醇酯的形成，其 IC50 值为 26.0 μM。

文献信息

• PROCESS FOR PRODUCING PLANT EXTRACT CONTAINING PLANT POWDER
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1407679A1

  公开（公告）日：2004-04-14

  The present invention relates to a method for producing a liquid plant extract containing plant powder, which comprises concentrating a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from aplant containing the active ingredient; aprocess for producing a plant extract containing plant powder, which is characterized by comprises concentrating and drying a liquid extract containing an active ingredient in the presence of the plant powder, the liquid extract being obtained from a plant containing the active ingredient; a liquid plant extract or plant extract containing plant powder which comprises a liquid extract or plant extract containing the active ingredient obtained from a plant containing the active ingredient and comprises plant powder, and in which the content of the active ingredient in the liquid extract or plant extract is higher than that in the plant; and a food and drink or feed to which the liquidplant extract or plant extract containingplant powder is added.

  本发明涉及一种生产含有植物粉末的液态植物提取物的方法，该方法包括在植物粉末存在 的情况下浓缩含有活性成分的液态提取物，该液态提取物取自含有活性成分的植物； 一种生产含有植物粉末的植物提取物的工艺，其特征在于包括在植物粉末存在的情况下浓缩 和干燥含有活性成分的液态提取物，该液态提取物取自含有活性成分的植物；液态植物提取物或含有植物粉末的植物提取物，它包括从含有活性成分的植物中获得的液态提取物或含有活性成分的植物提取物，其中液态提取物或植物提取物中的活性成分含量高于植物中的含量；以及添加了液态植物提取物或含有植物粉末的植物提取物的食品和饮料或饲料。
• PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR LIGANDS AND PROCESS FOR PRODUCING THE SAME
  申请人：KANEKA CORPORATION

  公开号：EP1440688A1

  公开（公告）日：2004-07-28

  The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

  本发明简便高效地提供了一种过氧化物酶体增殖体激活受体配体，以及一种用于改善胰岛素抵抗或预防和/或改善胰岛素抵抗综合征的组合物，其中含有该配体作为活性成分。 本发明涉及一种过氧化物酶体增殖体激活受体配体，它包括一种前黄酮类化合物、一种不包括前黄酮类化合物的查尔酮衍生物、一种不包括前黄酮类化合物的黄酮醇衍生物，以及可作为药物制剂或食品或饮料的盐、苷和/或酯化物质；一种含有上述配体的组合物；一种含有上述配体的植物提取物；以及一种生产上述提取物的工艺。
• PROCESSED FAT COMPOSITION FOR PREVENTING/AMELIORATING LIFESTYLE-RELATED DISEASES
  申请人：KANEKA CORPORATION

  公开号：EP1649854A1

  公开（公告）日：2006-04-26

  The obj ect of the invention is to provide a composition for prevention and/or amelioration of life-style related disease, and/or a composition for inhibition and/or amelioration of increase in body weight, comprising at least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3'-hydroxy-4'-O-methylglabridin, 4' -O-methylglabridin and hyspaglabridin B as compounds having a PPARγ ligand activity effective in amelioration of insulin resistance and in prevention and/or amelioration of life-style related diseases such as visceral fat obesity, type 2 diabetes, hyperlipemia and hypertension, which can be utilized in food and drink such as health food and health functional food (food for specifieduses and food with nutrient function) , pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. At least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3'-hydroxy-4'-O-methylglabridin, 4' -O-methylglabridin and hyspaglabridin B is dissolved in medium-chain fatty acid triglycerides and/or partial glycerides, whereby the stability of the compound (s) is improved and the processability thereof into food and drink, pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. is also improved.

  本发明的目的是提供一种用于预防和/或改善生活方式相关疾病的组合物，和/或一种用于抑制和/或改善体重增加的组合物，该组合物包含至少一种选自由格拉布林、格拉布林、格拉布醇、3'-羟基-4'-O-甲基格拉布林、4'-O-甲基格拉布林和 hyspaglabridin B 组成的组的化合物、4' -O-甲基格拉布甙和hypaglabridin B 作为具有 PPARγ 配体活性的化合物，可有效改善胰岛素抵抗，预防和/或改善与生活方式相关的疾病，如内脏脂肪肥胖、2 型糖尿病、高脂血症和高血压，可用于食品和饮料，如保健食品和保健功能食品（特定用途食品和具有营养功能的食品）、药物制剂、非药物制剂、化妆品等。将至少一种选自格拉布烯、格拉布林、格拉布罗尔、3'-羟基-4'-O-甲基格拉布林、4'-O-甲基格拉布林和 hyspaglabridin B 的化合物溶解在中链脂肪酸甘油三酯和/或部分甘油酯中，从而提高化合物的稳定性，并改善其加工成食品和饮料、药物制剂、非药物制剂、化妆品等的可加工性。
• OIL/FAT-CONTAINING COMPOSITION FOR SUPPRESSION OF CANCER DEVELOPMENT
  申请人：Kaneka Corporation

  公开号：EP1864643A1

  公开（公告）日：2007-12-12

  The present invention relates to an oil/fat-containing composition for suppressing carcinogenesis, the composition including a solution produced by bringing a hydrophobic extract of licorice, which has been produced by bringing licorice into contact with an alcohol, into contact with an oil/fat. According to the present invention, there are provided an oil/fat-containing composition for prevention or treatment of the cancer, which can act through oral administration, and can be safely ingested on a day-to-day basis, pharmaceuticals and foods containing the oil/fat-containing composition.

  本发明涉及一种用于抑制癌变的含油/脂组合物，该组合物包括一种溶液，该溶液是将甘草的疏水性提取物与油/脂接触后产生的，该提取物是将甘草与酒精接触后产生的。根据本发明，提供了一种用于预防或治疗癌症的含油/脂组合物，该组合物可以通过口服发挥作用，并且可以每天安全摄入，药品和食品中含有该含油/脂组合物。
• Use of a plant extract or plant juice
  申请人：Melbrosin International Produktions und Vertriebs GmbH & Co KG

  公开号：EP1925311A1

  公开（公告）日：2008-05-28

  Use of a plant extract or plant juice for the production of a pharmaceutical or nutritional preparation for the treatment of metabolic syndrome, wherein the plant extract or juice is from thyme, oregano, glove, nutmeg, red clover, bay leaves or red onion, as well as chemical compounds usually obtainable from plants for this use.

  将植物提取物或植物汁用于生产治疗代谢综合征的药物或营养制剂，其中植物提取物或植物汁来自百里香、牛至、手套、肉豆蔻、红三叶草、月桂叶或红洋葱，以及通常可从植物中获得的用于此用途的化合物。