Yinyanghuo D | 174286-25-0

• 物质功能分类: 生物化工 - 提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Yinyanghuo D
• 英文别名: 5,7-dihydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one
• CAS: 174286-25-0；119240-82-3
• 化学式: C₂₀H₁₈O₅
• 分子量: 338.4
• InChiKey: PFQMUQWFRINBBG-UHFFFAOYSA-N

物化性质

• 熔点：
  134-135 °C
• 沸点：
  589.9±50.0 °C(Predicted)
• 密度：
  1.314±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

制备方法与用途

Licoflavanone是一种黄烷酮，可以从风干的 G. glabra var. typica 植物的甲醇提取物中分离得到，并且具有抗菌活性。

文献信息

• Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof
  申请人：National University of Singapore

  公开号：US20030170292A1

  公开（公告）日：2003-09-11

  Methods for preparing an estrogenic preparation and isolating estrogenic compounds from a plant, such as an Epimedium plant, are provided. Also provided are estrogenic compounds from Epimedium plant that have been isolated and characterized, and methods for their use in modulating estrogen receptors and in treating conditions mediated by estrogen receptors, such as menopause and estrogen-dependent cancers. Also provided are preparations from Epimedium that are enriched for estrogenic compounds, and methods for their use in modulating estrogen receptors and preventing and treating conditions that are mediated by estrogen receptors.

  提供了制备雌激素制剂和从植物（如淫羊藿）中分离雌激素化合物的方法。还提供了从淫羊藿植物中分离并表征的雌激素化合物，以及将其用于调节雌激素受体和治疗由雌激素受体介导的疾病（如更年期和雌激素依赖性癌症）的方法。此外，还提供了从淫羊藿中富集雌激素化合物的制剂，以及将其用于调节雌激素受体、预防和治疗由雌激素受体介导的疾病的方法。
• METHODS FOR PREPARING AN ESTROGENIC PREPARATION AND ISOLATED ESTROGENIC COMPOUNDS FROM A PLANT AND USES THEREOF
  申请人：NATIONAL UNIVERSITY OF SINGAPORE

  公开号：EP1453827A1

  公开（公告）日：2004-09-08
• EP1453827A4
  申请人：——

  公开号：EP1453827A4

  公开（公告）日：2005-02-23
• US6750248B2
  申请人：——

  公开号：US6750248B2

  公开（公告）日：2004-06-15
• [EN] METHODS FOR PREPARING AN ESTROGENIC PREPARATION AND ISOLATED ESTROGENIC COMPOUNDS FROM A PLANT AND USES THEREOF<br/>[FR] PROCEDES DE FABRICATION D'UNE PREPARATION OESTROGENIQUE, COMPOSES OESTROGENIQUES TIRES D'UNE PLANTE ET UTILISATIONS
  申请人：UNIV SINGAPORE

  公开号：WO2003040134A1

  公开（公告）日：2003-05-15

  Methods for preparing an estrogenic preparation and isolating estrogenic compounds from a plant, such as an Epimedium plant, are provided. Also provided are estrogenic compounds from Epimedium plant that have been isolated and characterized, and methods for t heir use in modulating estrogen receptors and in treating conditions mediated by estrogen receptors, such as menopause and estrogen-dependent cancers. Also provided are preparations from Epimedium that are enriched for estrogenic compounds, and methods for their use in modulating estrogen receptors and preventing and treating conditions that are mediated by estrogen receptors.