3-{(2E)-3-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]prop-2-enoyl}-2H-chromen-2-one | 1609628-26-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-{(2E)-3-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]prop-2-enoyl}-2H-chromen-2-one
• 英文别名: 3-[(E)-3-(4-allyloxy-3-methoxy-phenyl)prop-2-enoyl]chromen-2-one；3-[(E)-3-(3-methoxy-4-prop-2-enoxyphenyl)prop-2-enoyl]chromen-2-one
• CAS: 1609628-26-3
• 化学式: C₂₂H₁₈O₅
• 分子量: 362.382
• InChiKey: FRZHUMBSOYGMCU-CSKARUKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  香草醛 在 potassium carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 6.0h， 生成 3-{(2E)-3-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]prop-2-enoyl}-2H-chromen-2-one
  参考文献：
  名称：

  Design, economical synthesis and antiplasmodial evaluation of vanillin derived allylated chalcones and their marked synergism with artemisinin against chloroquine resistant strains of Plasmodium falciparum

  摘要：

  The in vitro blood stage antiplasmodial activity of a series of allylated chalcones based on the licochalcone A as lead molecule was investigated against chloroquine (CQ) sensitive Pf3D7 and CQ resistant PfINDO strains of Plasmodium falciparum using SYBR Green I assay. Of the forty two chalcones tested, eight showed IC50 < 5 mu M. Structure-activity relationship (SAR) studies revealed 9 {1-(4-Chlorophenyl)-3-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]-prop-2-en-1-one} as the most potent (IC50: 2.5 mu M) against Pf3D7 with resistance indices of 1.2 and 6.6 against PfDd2 and PfINDO strains, respectively. Later on, the synergistic effects 9 with standard antimalarials fartemisinin (ART) and chloroquine (CQ)} were studied in order to provide the basis for the selection of the best partner drug. In vitro combinations of 9 with ART showed strong synergy against PfINDO (Sigma FIC50: 0.31-0.72) but additive to slight antagonistic effects (Sigma FIC50: 1.97-2.64) against Pf3D7. Sigma FIC50 0.31 of ART+9 combination corresponded to a 320 fold and 3 fold reduction in IC50 of 9 and ART, respectively. Similar combinations of 9 with CQ showed synergy to additivity to mild antagonism against the two strains {Sigma FIC50: 0.668-2269 (PfINDO); 1.45-2.83 (Pf3D7)}. Drug exposure followed by drug withdrawal indicated that 9 taken alone at IC100 killed rings, trophozoites and schizonts of P. falciparum. The combination of ART and 9 (1X Sigma FIC100) selectively inhibited the growth of rings while the 2X Sigma FIC100 combination of the same caused killing of rings without affecting trophozoites and schizonts. In contrast, the 1x combination of CQ and 9 (Sigma FIC100: 0.5) killed rings and trophozoites. DNA fragmentation and loss of mitochondrial membrane potential (Delta Psi m) in the 9 treated P. falciparum culture indicated apoptotic death in malaria parasites. Prediction of ADME properties revealed that most of the molecules did not violate Lipinski's parameters and have low TPSA value suggesting good absorption. The results suggest the promising drug-like properties of 9 against CQ resistant Pf and propensity for synergy with classical antimalarial drugs together with easy and economical synthesis. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.03.079

文献信息

• Synthesis and in vitro SAR evaluation of natural vanillin-based chalcones tethered quinolines as antiplasmodial agents
  作者：Nitin H. Andhare、Mohammad Anas、Sumit K. Rastogi、Ashan Manhas、Yogesh Thopate、Kumkum Srivastava、Niti Kumar、Arun K. Sinha

  DOI：10.1007/s00044-022-02975-y

  日期：2022.12

  A series of novel chalcone derivatives were synthesized and investigated against the chloroquine-sensitive P. falciparum 3D7 (Pf3D7) strain and chloroquine-resistant P. falciparum K1 strain to establish their structure-activity relationship. In this study, compound 7 was found most active as well as less cytotoxic (IC50 = 4.12 µM and 3.14 µM for Pf3D7 and PfK1 respectively; CC50 = 46.18 µM). Compound

  合成了一系列新型查尔酮衍生物，并针对氯喹敏感的恶性疟原虫3D7 ( Pf 3D7) 菌株和耐氯喹的恶性疟原虫K1 菌株进行了研究，以建立它们的构效关系。在这项研究中，化合物7的活性最高且细胞毒性较低（Pf 3D7和 Pf K1的 IC 50  = 4.12 µM 和 3.14 µM ；CC 50  = 46.18 µM）。研究了化合物 7 对寄生虫生长的影响，显微镜检查显示滋养体阶段的 DNA 损伤过度。由于化合物的显着遗传毒性作用，药物去除后的寄生虫恢复很差7 . 这表明 7-氯喹啉和三唑键对抗疟潜力至关重要。