2-heptylimidazole | 56750-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-heptylimidazole
• 英文别名: 2-Heptyl-1H-imidazole
• CAS: 56750-07-3
• 化学式: C₁₀H₁₈N₂
• 分子量: 166.266
• InChiKey: ABLCFODXAYBNID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-heptylimidazole 在 sodium methylate 、 铁粉 、 溶剂黄146 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 29.5h， 生成 2-[[4-[(2-Heptylimidazol-1-yl)methyl]phenyl]carbamoyl]benzoic acid
  参考文献：
  名称：

  有效的非肽类血管紧张素II受体拮抗剂的发现：一类新型的高效降压药。

  摘要：

  已经发现了一类新型的有效降压药，它们通过阻断血管紧张素II（AII）受体发挥作用。迄今为止，大多数报道的AII拮抗剂都是内源性血管收缩八肽血管紧张素II的肽模拟物。本文的化合物是非肽，因此构成了一类新的有效的AII受体拮抗剂。基于AII构象与文献铅3的重叠，提出了一个假设，提示需要额外的酸性功能以增加铅的效力。通过系统的SAR研究，对另一种羧酸的取代导致对二酸4的观察到的结合亲和力增加了10倍。对于后续化合物的结合亲和力最终比文献上的结果增加了1000倍。因此，例如，对于化合物前导1，AII受体结合亲和力[IC50（microM）]为15 microM，对于化合物33和53，增加到0.018和0.012 microM。已经发现结构亲和关系需要存在四个关键具有良好活性的元素：（1）在苄基咪唑核的N-苄基对位上有一个额外的苯环，（2）在末端芳环的邻位上有一个酸性官能团，（3）在咪唑上有一个亲脂

  DOI：

  10.1021/jm00167a007
• 作为产物：
  描述：

  辛酸 、 乙二胺 在 Pt/Al₂O₃ 、 AP-64K platinum-alumina catalyst 氢气 作用下， 生成 2-heptylimidazole
  参考文献：
  名称：

  Catalytic synthesis of C-alkylimidazoles over platinum-alumina catalysts

  摘要：

  The synthesis of C-alkylimidazoles from 1,2-diamines and carboxylic acids over bifunctional, platinum-alumina catalysts has been studied. It has been shown that this method is effective for the synthesis of 2-alkyl and 2,4-dialkylimidazoles including imidazoles with long-chain alkyls. The effect of the reaction temperature, space velocity of the flow of the raw materials, and dilution by hydrogen on the yield of product has been examined for the example of the synthesis of 2-methylimidazole from ethylenediamine and acetic acid, and the stability of the catalyst in continuous reaction cycles with intermediate oxidative regeneration has been studied. The composition of the accompanying products has been established and a mechanism proposed for their formation.

  DOI：

  10.1007/bf01150900

文献信息

• [EN] HETEREOCYCLIC AGENT AS CATALYTIC STABILIZING AGENT IN A HYDROFORMYLATION PROCESS<br/>[FR] AGENT HÉTÉROCYCLIQUE COMME AGENT DE STABILISATION CATALYTIQUE DANS UN PROCÉDÉ D'HYDROFORMYLATION
  申请人：DOW TECHNOLOGY INVESTMENTS LLC

  公开号：WO2014149915A1

  公开（公告）日：2014-09-25

  A heterocyclic nitrogen stabilizing agent is employed to reduce the rate of catalyst deactivation in a hydroformylation process.

  在氢甲酰化过程中，使用杂环氮稳定剂来降低催化剂失活的速率。
• BENZYL ARALKYL ETHER COMPOUNDS, METHOD FOR PREPARING SAME, INTERMEDIATE COMPOUNDS, USE OF SAID COMPOUNDS, METHOD FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND MEDICAMENT CONTAINING SAME
  申请人：Keppler Artur Franz

  公开号：US20120196908A1

  公开（公告）日：2012-08-02

  This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I): wherein: Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil; R 1 , R 2 , R 4 and R 5 are independently hydrogen, halogen, C 1-6 alkyl; R 3 represents halogen, C 1-6 alkyl or O—R′ where R′ represents hydrogen or lower alkyl; R 6 represents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O—R′ where R′ represents hydrogen or lower alkyl; being the substituents of the aryl a halogen or a radical tetrazolyl; n and m represent independently an integer between 0 and 5; With the proviso that when Ar is imidazolil, R 3 is chlorine, R 6 is p-phenyl and R 1 , R 2 , R 4 and R 5 are hydrogen, n must be different from 2. When n and m are not 0 and 1, R 3 or R 6 can be represented by substituents not necessarily equal. This invention also refers to their salts, solvates, prodrugs, esters, enantiomers and/or pharmaceutically acceptable diastereoisomers, or mixtures thereof, processes for the preparation of these compounds, intermediate compounds, pharmaceutical compositions comprising such compounds and/or derivatives, including those compounds and/or derivatives, as well as the uses and methods of these compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by microorganisms such as fungi, bacteria and/or protozoa, for the inhibition of proliferation and/or survival of said microorganisms, for the treatment and/or prevention of colonization of microorganisms in an individual, and for the manufacture of a medicine.

  该发明描述了一种新的抗真菌化合物，它们是公式（I）的芳基烷基苯醚，其中：Ar代表芳基，咪唑基，1,2,4-三唑基，苯并咪唑基；R1、R2、R4和R5独立地代表氢、卤素、C1-6烷基；R3代表卤素、C1-6烷基或O—R′，其中R′代表氢或较低的烷基；R6代表芳基、取代芳基、三氟甲基、三氯甲基或O—R′，其中R′代表氢或较低的烷基；芳基的取代基是卤素或四唑基基团；n和m分别表示介于0和5之间的整数；但是当Ar为咪唑基，R3为氯，R6为对苯基且R1、R2、R4和R5为氢时，n必须不等于2。当n和m不为0和1时，R3或R6可以用不必相等的取代基表示。该发明还涉及它们的盐、溶剂合物、前药、酯、对映体和/或药学上可接受的对映异构体或它们的混合物，制备这些化合物的过程，中间体化合物，包括这些化合物和/或衍生物的制药组合物，以及这些化合物和/或衍生物的用途和方法，用于治疗和/或预防由微生物引起的疾病和/或疾病，如真菌、细菌和/或原虫，用于抑制这些微生物的增殖和/或生存，用于治疗和/或预防微生物在个体中的定殖，并用于制药。
• Powder coating composition
  申请人：SOMAR CORPORATION

  公开号：EP0385745A2

  公开（公告）日：1990-09-05

  A powder coating composition is disclosed which includes an epoxy resin which is solid at room temperature, and a curing agent, characterized in that the curing agent includes an adduct obtained by reaction of (a) a polyfunctional epoxy resin, (b) an imidazole compound having a secondary amino group in the imidazole ring thereof and (c) a polyhydric phenol.

  本发明公开了一种粉末涂料组合物，它包括一种在室温下为固体的环氧树脂和一种固化剂，其特征在于固化剂包括由以下物质反应得到的加合物：(a) 多官能团环氧树脂；(b) 在咪唑环上具有仲氨基的咪唑化合物；(c) 多氢苯酚。
• COMPOSITION FOR SEALING OPTICAL SEMICONDUCTOR, OPTICAL SEMICONDUCTOR SEALING MATERIAL, AND METHOD FOR PRODUCING COMPOSITION FOR SEALING OPTICAL SEMICONDUCTOR
  申请人：JSR Corporation

  公开号：EP1736500A1

  公开（公告）日：2006-12-27

  A polyorganosiloxane having a weight average molecular weight of 500 to 1,000,000 obtained by heating a silane compound having an epoxy group and a silane compound having no epoxy group in the presence of an organic solvent, an organic base and water, an optical semiconductor sealing composition comprising the same as the main component, an optical semiconductor sealer and an optical semiconductor.

  在有机溶剂、有机碱和水的存在下，加热具有环氧基团的硅烷化合物和不具有环氧基团的硅烷化合物而得到的重量平均分子量为 500-1,000,000 的聚有机硅氧烷、以其为主要成分的光学半导体密封组合物、光学半导体密封剂和光学半导体。
• METHOD FOR PRODUCING METAL PARTICLE DISPERSION, CONDUCTIVE INK USING METAL PARTICLE DISPERSION PRODUCED BY SUCH METHOD, AND CONDUCTIVE COATING FILM
  申请人：Toyo Ink Mfg. Co., Ltd

  公开号：EP1952918A1

  公开（公告）日：2008-08-06

  Disclosed is a method for producing a metal particle dispersion wherein a metal compound is reduced by using carbodihydrazide represented by the formula (1) below or a polybasic acid polyhydrazide represented by the formula (2) below (wherein R represents an n-valent polybasic acid residue) in a liquid medium. By reducing the metal compound in the presence of a compound having a function preventing discoloration of the metal, there can be obtained a metal particle dispersion having excellent discoloration preventing properties. Metal particles produced by such methods have a uniform particle diameter and are excellent in dispersion stability. By using a conductive resin composition or conductive ink containing a metal particle dispersion obtained by such production methods, there can be formed a conductive coating film, such as a conductive circuit or an electromagnetic layer, having good characteristics.

  本发明公开了一种生产金属颗粒分散液的方法，该方法通过在液体介质中使用下式 (1) 所代表的碳二酰肼或下式 (2) 所代表的多基酸多酰肼（其中 R 代表正价多基酸残基）还原金属化合物。通过在具有防止金属褪色功能的化合物存在下还原金属化合物，可获得具有优异防褪色性能的金属颗粒分散液。通过这种方法制得的金属颗粒具有均匀的颗粒直径和出色的分散稳定性。使用含有通过这种生产方法获得的金属颗粒分散体的导电树脂组合物或导电墨水，可以形成具有良好特性的导电涂膜，例如导电电路或电磁层。