3,3'-(4-isopropylbenzylidene)-bis-(4-hydroxycoumarin) | 200060-89-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,3'-(4-isopropylbenzylidene)-bis-(4-hydroxycoumarin)
• 英文别名: 2-Hydroxy-3-[(2-hydroxy-4-oxo-chromen-3-yl)-(4-propan-2-ylphenyl)methyl]chromen-4-one；4-hydroxy-3-[(4-hydroxy-2-oxochromen-3-yl)-(4-propan-2-ylphenyl)methyl]chromen-2-one
• CAS: 200060-89-5
• 化学式: C₂₈H₂₂O₆
• 分子量: 454.479
• InChiKey: HJFQCLUSKVFGHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 、 4-异丙基苯甲醛 在 bael fruit ash 作用下， 以 水 为溶剂， 反应 0.33h， 以89%的产率得到3,3'-(4-isopropylbenzylidene)-bis-(4-hydroxycoumarin)
  参考文献：
  名称：

  Aegle marmelos果灰在合成双香豆素和2-amino-4 H-chromenes中的协同作用

  摘要：

  摘要 的干燥果皮木橘（巴尔）水果灰分作为协同替代材料昂贵，有毒和腐蚀性催化剂biscoumarins的合成和2-氨基-4- ħ -chromenes在水环境温度被报告。来自EDL，FTIR，XRD和SEM分析的光谱学证据证明了贝尔果灰的存在，这些金属氧化物，碳酸盐和氢氧化物的存在对反应的加速起着至关重要的作用。该协议的显着特征是利用生物废物，具有成本效益，可回收和可生物降解的催化系统，该系统可在短反应时间内提供良好或优异的收率。 图形摘要

  DOI：

  10.1007/s11164-020-04367-6

文献信息

• Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives
  作者：Jing Li、Xiao-yan Xue、Xia Li、Zheng Hou、Xiao-hui Yang、Di Qu、Ying Zhou、Zi-dan Zhang、Xiao-xing Luo、Jiang-tao Li、Ming-kai Li

  DOI：10.1007/s12272-015-0614-7

  日期：2016.10

  A series of bisoumarin (1–4) and dihydropyran (5–8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffraction study. Among these compounds tested toward Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC), compounds 1 and 2 displayed the most potent antibacterial activity. Additionally, the HB energy in biscoumarins 1–4 was calculated by density functional theory (DFT) [B3LYP/6-31G*] method.

  一系列双香豆素（1–4）和二氢吡喃（5–8）衍生物作为新的抗菌剂成功合成。通过单晶X射线衍射研究确认了三种代表性化合物1、5和7的分子结构。在针对金黄色葡萄球菌（S. aureus ATCC 29213）、耐甲氧西林金黄色葡萄球菌（MRSA XJ 75302）、万古霉素中介金黄色葡萄球菌（Mu50 ATCC 700699）和美国300（洛杉矶县克隆，LAC）进行测试的化合物中，化合物1和2表现出了最强的抗菌活性。此外，通过密度泛函理论（DFT）[B3LYP/6-31G*]方法计算了双香豆素1–4中的氢键能。
• Tetrabutylammonium bromide (TBAB): a neutral and efficient catalyst for the synthesis of biscoumarin and 3,4-dihydropyrano[c]chromene derivatives in water and solvent-free conditions
  作者：Jitender M. Khurana、Sanjay Kumar

  DOI：10.1016/j.tetlet.2009.04.125

  日期：2009.7

  A simple, efficient and ecofriendly procedure has been developed using tetrabutylammonium bromide as catalyst for the synthesis of biscoumarin and dihydropyrano[c]chromene derivatives in water and solvent-free neat conditions. The present methodology offers several advantages such as excellent yields, short reaction time and environmentally benign milder reaction conditions.

  使用四丁基溴化铵作为催化剂，在水和无溶剂纯净条件下合成双香豆素和二氢吡喃并[ c ]色烯衍生物，已开发出一种简单，高效且环境友好的方法。本方法提供了许多优点，例如优异的产率，短的反应时间和对环境无害的温和的反应条件。
• Chickpea leaf exudates (CLE) mediated Knoevenagel–Michael reactions for the synthesis of diketodiols and biscoumarins
  作者：Rupesh C. Patil、Dnyandev N. Zambare、Shashikant A. Damate、Ashutosh A. Jagdale、Snehali R. Mali、Sachinkumar K. Shinde、Suresh S. Patil

  DOI：10.1007/s11164-022-04707-8

  日期：2022.5

  A green, highly efficient, and eco-friendly protocol for Knoevenagel–Michael addition reaction is reported in Chickpea leaf exudates (CLE) as a naturally sourced biosurfactant. The reactions between dimedone/4-hydroxycoumarins and a variety of aryl aldehydes were carried out in presence of CLE to afford diketodiols/biscoumarins. The synthetic pathway complies with several key requirements of green chemistry principles such as the employment of natural feedstock as green reaction media, ambient temperature, atom economy along with natural biosurfactant type Bronsted acids, and recyclable and biodegradable catalyst which led to a 28-fold increase in molar efficiency versus industrial standard protocols. Its dynamic phase is confirmed by the optical microscopy technique and critical micelle concentration measurement. The notable advantages of the present protocol were simple work-up procedure, high yield within short reaction time, easy separation of products, avoiding tedious column chromatography thus making the protocol environmentally friendly, sustainable, and economical.

  报告采用鹰嘴豆叶渗出物（CLE）作为天然生物表面活性剂，提出了一种绿色、高效、环保的 Knoevenagel-Michael 加成反应方案。在 CLE 的存在下，二酮/4-羟基香豆素与多种芳基醛发生反应，生成二酮二醇/双香豆素。该合成途径符合绿色化学原则的几个关键要求，如使用天然原料作为绿色反应介质、环境温度、原子经济性以及天然生物表面活性剂型勃朗斯特酸和可回收和生物降解催化剂，与工业标准协议相比，摩尔效率提高了 28 倍。光学显微镜技术和临界胶束浓度测量证实了其动态阶段。本方案的显著优点是操作步骤简单，反应时间短，产率高，产品易于分离，避免了繁琐的柱层析，从而使该方案具有环境友好性、可持续性和经济性。
• Mohr's Salt Hexahydrate: A Novel, Cheap and Powerful Reagent for Green Synthesis of Biscoumarins on Water
  作者：Saeed Khodabakhshi、Mojtaba Baghernejad

  DOI：10.1002/jccs.201200489

  日期：2013.5

  A new and convenient method for the synthesis of biscoumarins based on the condensation of 4‐hydroxycoumarin and aromatic aldehydes in the presence of Mohr's salt hexahydrate (ferrous ammonium sulfate hexahydrate) as a novel catalyst on water is developed. This method has advantages such as the use of inexpensive and available reagent, avoidance of organic solvents, short reaction times, and high product

  开发了一种新的便捷的合成双香豆素的方法，该方法基于4-羟基香豆素和芳香醛在莫尔盐六水合物（六水合硫酸亚铁铵）存在下作为水的新型催化剂的缩合反应。该方法的优点是例如使用廉价和可用的试剂，避免有机溶剂，反应时间短和产物产率高。
• Image making medium
  申请人：——

  公开号：US20030035917A1

  公开（公告）日：2003-02-20

  The invention relates to an image support medium for creation of an aesthetic image that is an work or object for display. This support medium includes a polymer in an amount sufficient to enable the image to have at least one aesthetic element. In different embodiments, the image support medium is an image support stabilizer, the polymer is a synthetic absorbent or conductive polymer, or the polymer is a transparent or synthetic translucent polymer and a property of this transparent or translucent polymer is enhanced to facilitate the creation or preservation of the image by at least one stabilizer. The invention also relates to a method for preparing this image support medium. The method includes forming a reaction mixture comprising a monomer in an amount sufficient to provide or enable the image to have an aesthetic element, and processing the reaction mixture into a 2- or 3-dimensional shape.

  本发明涉及一种图像支持介质，用于创建作为作品或展示对象的美学图像。这种支撑介质包括一种聚合物，其用量足以使图像具有至少一种审美元素。在不同的实施例中，图像支持介质是一种图像支持稳定剂，聚合物是一种合成的吸收性或导电性聚合物，或者聚合物是一种透明或合成的半透明聚合物，并且这种透明或半透明聚合物的特性被至少一种稳定剂增强，以促进图像的创建或保存。本发明还涉及一种制备这种图像支持介质的方法。该方法包括形成由单体组成的反应混合物，其用量足以提供或使图像具有美学元素，并将反应混合物加工成 2 维或 3 维形状。