2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one | 13463-28-0

• 物质功能分类: 生物化工 - 提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
• CAS: 13463-28-0
• 化学式: C₂₇H₃₂O₁₅
• 分子量: 596.5
• InChiKey: OMQADRGFMLGFJF-UHFFFAOYSA-N

物化性质

• 熔点：
  161-190°C
• 沸点：
  956.9±65.0 °C(Predicted)
• 密度：
  1.77
• 溶解度：
  DMSO（微溶）、甲醇
• LogP：
  1.470 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  245
• 氢给体数：
  9
• 氢受体数：
  15

安全信息

• WGK Germany：
  3
• 海关编码：
  29389090
• 安全说明：
  S22,S24/25
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

制备方法与用途

生物活性

Eriocitrin 是从柠檬中分离出来的一种黄酮类化合物，是一种强效的抗氧化剂。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞，从而抑制肝癌细胞的增殖。此外，Eriocitrin 还能激活线粒体涉及的内在信号传导途径，触发细胞凋亡。

化学性质

Eriocitrin 是一种淡黄色粉末，可溶于甲醇、乙醇和 DMSO 等有机溶剂。它来源于柠檬等柑橘属果树。

用途

Eriocitrin 主要用于含量测定、鉴定以及药理实验等。作为一种具有较强抗氧化效果的物质，常被用作饮料、食品和酒类中的抗氧化剂。圣草次苷能够抑制大鼠肝脏因急性运动引起的氧化应激损伤，并且具有降血脂的作用。其抗氧化能力优于橙皮苷和柚皮苷。

用途

圣草次苷可以有效抑制大鼠肝脏因急性运动引起的氧化应激损伤，同时具备显著的降血脂作用。它的抗氧化能力也明显优于橙皮苷和柚皮苷等其他化合物。

文献信息

• Compositions and methods for joint health
  申请人：Unigen, Inc.

  公开号：US11123393B2

  公开（公告）日：2021-09-21

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

  本公开提供了前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物，能够调节关节炎症、关节疼痛、关节僵硬、软骨退化，或改善活动能力、活动范围、柔韧性、关节物理功能或其任意组合。这种前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物可以选择性地与其他关节调理剂结合使用，如非甾体抗炎剂/镇痛剂、COX/LOX 抑制剂、氨基葡萄糖化合物、神经性疼痛缓解剂等。
• COMPOSITIONS AND METHODS FOR JOINT HEALTH
  申请人：Unigen, Inc.

  公开号：US20150072953A1

  公开（公告）日：2015-03-12

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.
• Compositions and Methods for Joint Health
  申请人：Unigen, Inc.

  公开号：US20160067296A1

  公开（公告）日：2016-03-10

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.
• [EN] COMPOSITIONS AND METHODS FOR JOINT HEALTH<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR DES ARTICULATIONS SAINES
  申请人：UNIGEN INC

  公开号：WO2014204866A1

  公开（公告）日：2014-12-24

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.