1-ubiquinol | 75426-26-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-ubiquinol
• 英文别名: ubiquinol-10；Coenzym-Q(10)-hydrochinon；reduced coenzyme Q10；2,3-dimethoxy-5-methyl-6-decaisoprenyl-1,4-dihydroxybenzene；Ubiquinol-10;CoQH2-10；2-(3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl)-5,6-dimethoxy-3-methylbenzene-1,4-diol
• CAS: 75426-26-5
• 化学式: C₅₉H₉₂O₄
• 分子量: 865.377
• InChiKey: QNTNKSLOFHEFPK-UHFFFAOYSA-N

物化性质

• 沸点：
  866.9±65.0 °C(Predicted)
• 密度：
  0.951±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  20.2
• 重原子数：
  63
• 可旋转键数：
  31
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-ubiquinol 在 吡啶 、 盐酸 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 丙酮 为溶剂， 反应 24.0h， 生成 2,3-dimethoxy-5-methyl-6-decaisoprenyl-4-hydroxybenzene 1-sarcosinate hydrochloride
  参考文献：
  名称：

  DERMATOLOGICAL AGENT

  摘要：

  本发明的目的是提供皮肤学制剂，例如美白剂和促进毛发生长的剂，其包含具有高水溶性和特定结构的化合物，能够释放2,3-二甲氧基-5-甲基-1,4-二羟基苯（还原形式）。根据本发明的皮肤学制剂包含下述一般式（I）所表示的2,3-二甲氧基-5-甲基-1,4-二羟基苯甲酸酯衍生物或其盐：其中在式（I）中，R1，R2和R3是特定的基团。

  公开号：

  US20110144376A1
• 作为产物：
  描述：

  磷酸二氢2-甲基-1,1-二羟基-3-(吡啶-2-基氨基甲酰)-2H-1,2-苯并噻嗪-4-酯 在 sodium tetrahydroborate 、 异丙醚 作用下， 以 甲醇 为溶剂， 反应 0.05h， 生成 1-ubiquinol
  参考文献：
  名称：

  Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

  摘要：

  这项研究的目的是开发泛醌醇-10（UqH-10）的前药，它是泛醌酮-10（Uq-10）的活性形式，用于口服给药。UqH-10的生物利用度受到其易氧化和水不溶性的影响。我们制备了三种新型的N，N-二甲基甘氨酸酯衍生物，包括1-单酯（UqH-1-DMG）、4-单酯（UqH-4-DMG）和1,4-双酯（UqH-DMG），并在体外和体内评估了它们的理化性质。UqH-DMG在36.5°C时自发形成了一个包含20纳米颗粒的水性胶束溶液。阳离子UqH-DMG与牛磺胆酸形成了5纳米的混合胶束。在人类肝微粒体中，衍生物重新转化为UqH-10的速度加快。给予UqH-衍生物或Uq-10后，在禁食和饮食后的正常和高胆汁水平大鼠体内测定了UqH-10的口服生物利用度。在禁食大鼠中，给予UqH-衍生物后血浆中的UqH-10在2-3小时达到Cmax，而给予Uq-10后，其保持较低。给予UqH-衍生物后的UqH-10的AUC0-24h比给予Uq-10后高2-3倍。在饮食后的大鼠中，给予UqH-衍生物后的UqH-10的Tmax比给予Uq-10后提前一个小时。总之，阳离子UqH-衍生物是方便的前药，通过与肠道胆汁酸形成纳米级混合胶束来增强UqH-10的生物利用度。

  DOI：

  10.3390/molecules25030546

文献信息

• [EN] COCRYSTALS OF UBIQUINOL AND COMPOSITIONS COMPRISING THEM<br/>[FR] CO-CRISTAUX D'UBIQUINOL ET COMPOSITIONS LES COMPRENANT
  申请人：CENTER FOR INTELLIGENT RES IN CRYSTAL ENGINEERING S L

  公开号：WO2019162429A1

  公开（公告）日：2019-08-29

  The present invention relates to a cocrystal of ubiquinol and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.

  本发明涉及一种辅酶Q10醌和氢键供体协同剂的共晶体，其制备方法以及其作为药物或膳食补充剂的使用。本发明还涉及包含该共晶体的组合物。
• Antiaging composition
  申请人：Fujii Kenji

  公开号：US20050154066A1

  公开（公告）日：2005-07-14

  The object of the present invention is to provide a composition which is effective in retarding or preventing the development of energy decrease, appearance change, etc. of humans and animals due to aging, and is highly safe even with a long period of taking. The present invention relates to an antiaging composition which comprises reduced coenzyme Q as an active ingredient. By feeding mice which develop the aging symptom early (aging-accelerated model mice) with a feed containing reduced coenzyme Q 10 for a long period of time, aging process was prevented and retarded. Furthermore, aging-accelerated model mice fed with reduced coenzyme Q 10 for a long period of time showed no toxic symptom, thus it was found that the antiaging composition comprising a composition containing said substance can be made into a safe antiaging composition capable of being taken for a long period of time.

  本发明的目的是提供一种组成物，该组成物能够有效地延缓或预防因衰老而导致的人类和动物的能量减少、外观变化等，并且即使长期服用也非常安全。本发明涉及一种抗衰老组成物，其包含还原型辅酶Q作为活性成分。通过长期喂养早期出现衰老症状的小鼠（衰老加速模型小鼠）含有还原型辅酶Q10的饲料，可以预防和延缓衰老过程。此外，长期喂养还原型辅酶Q10的衰老加速模型小鼠没有显示出有毒症状，因此发现包含该物质的组成物可以制成一种安全的抗衰老组成物，可长期服用。
• COCRYSTALS OF UBIQUINOL AND COMPOSITIONS COMPRISING THEM
  申请人：Center for Intelligent Research in Crystal Engineering, S.L.

  公开号：EP3755683A1

  公开（公告）日：2020-12-30
• MELT-STABILIZED ULTRA HIGH MOLECULAR WEIGHT ANTIOXIDANT
  申请人：Zimmer, Inc.

  公开号：US20160280863A1

  公开（公告）日：2016-09-29

  Various embodiments disclosed relate to melt-stabilized ultra high molecular weight antioxidant, methods of making the same, and medical implants made from the same. In various embodiments, the present invention provides a method of melt-stabilizing ultra high molecular weight polyethylene (UHMWPE). The method can include coating a solid material including LIMA/PE with an antioxidant, to provide an antioxidant-coated solid material. The method can include pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material. The method can include irradiating the antioxidant-diffused solid material, to provide an irradiated solid material. The method can include post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. The method can also include solidifying the heated material, to provide a melt-stabilized material.
• Compositions comprising Quinone and/or Quinol and methods of preparations and use thereof
  申请人：American River Nutrition, LLC

  公开号：US20210113491A1

  公开（公告）日：2021-04-22

  The present embodiments are directed to compositions of quinones and/or quinols, such as, but not limited to, ubiquinone and/or ubiquinol, vitamin E quinone and/or vitamin E quinol, vitamin K quinone and/or vitamin K quinol, menaquinones and/or menaquinols, and pyrroloquinoline quinone and/or pyrroloquinoline quinol, and methods for preparations and use thereof. The present embodiments are also directed to compositions of reduced forms of curcuminoid and methods for preparations and use thereof.