dihydro-3,4-diveratryl-2(3H)-furanone | 4773-01-7

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 呋喃类木脂素
• 英文名称: dihydro-3,4-diveratryl-2(3H)-furanone
• 英文别名: 3,4-bis-(3,4-dimethoxy-benzyl)-dihydro-furan-2-one；3,4-diveratryl-dihydro-furan-2-one；3,4-Diveratryl-dihydro-furan-2-on；Dimethylmatairesinol；3,4-bis[(3,4-dimethoxyphenyl)methyl]oxolan-2-one
• CAS: 4773-01-7
• 化学式: C₂₂H₂₆O₆
• 分子量: 386.445
• InChiKey: SNAOLIMFHAAIER-UHFFFAOYSA-N

物化性质

• 熔点：
  126.5-127 °C(Solv: ethanol (64-17-5))
• 沸点：
  545.6±45.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dihydro-3,4-diveratryl-2(3H)-furanone 生成 (3S)-3,4-bis[(3,4-dimethoxyphenyl)methyl]-3-hydroxyoxolan-2-one
  参考文献：
  名称：

  KHAMLACH, KENZA;DHAL, ROBERT;BROWN, ERIC, TETRAHEDRON LETT., 30,(1989) N7, C. 2221-2224

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-双(3,4-二甲氧基亚苄基)丁二酸 在 H4Ru4(CO)84 氢气 作用下， 以 甲苯 为溶剂， 180.0 ℃ 、28.0 MPa 条件下， 反应 48.0h， 以94%的产率得到dihydro-3,4-diveratryl-2(3H)-furanone
  参考文献：
  名称：

  New Synthetic Route to Butanolide Lignans by a Ruthenium Complex Catalyzed Hydrogenation of the Corresponding Stobbe's Fulgenic Acids

  摘要：

  DOI：

  10.3987/com-88-4321

文献信息

• PHARMACEUTICAL COMPOSITIONS COMPRISING 8-SUBSTITUTED DIBENZYLBUTYROLACTONE LIGNANS
  申请人：Peuhu Emilia

  公开号：US20130281381A1

  公开（公告）日：2013-10-24

  Therapeutic compositions comprising at least one 8-substituted-dibenzylbutyrolactone lignan, preferably a lignan is selected from the group of nortrachelogenin, diasteromeric forms of nortrachelogenin, isomeric forms of nortrachelogenin and combinations thereof as well as 8-methylmatairesinol and 8-methyldimethylmatairesinol, for use in a method of treating cancer or a similar condition wherein the growth factor signaling pathway of a mammal is deregulated. The invention also provides therapeutic pharmaceutical combinations comprising a hydroxy-dibenzylbutyrolactone lignan and at least one TRAIL receptor agonist. The hydroxy-dibenzylbutyrolactone lignans and a TRAIL receptor agonist can be used as a combined preparation for administration to a patient simultaneously, separately or spaced out over a period of time in treating cancer.

  治疗组合物包括至少一种8-取代-二苯基丁酸内酯木脂素(lignan)，优选的木脂素选自nortrachelogenin、nortrachelogenin的对映异构体、nortrachelogenin的异构体和它们的组合，以及8-甲基马铁脂素和8-甲基二甲基马铁脂素，用于治疗哺乳动物生长因子信号通路失调引起的癌症或类似疾病的方法。本发明还提供了治疗性药物组合物，包括羟基-二苯基丁酸内酯木脂素和至少一种TRAIL受体激动剂。羟基-二苯基丁酸内酯木脂素和TRAIL受体激动剂可以作为联合制剂同时、分开或在一段时间内间隔使用，用于治疗癌症。
• Pharmaceutical compositions comprising 8-substituted dibenzylbutyrolactone lignans
  申请人：Peuhu Emilia

  公开号：US09168243B2

  公开（公告）日：2015-10-27

  Therapeutic compositions comprising at least one 8-substituted-dibenzylbutyrolactone lignan, preferably a lignan is selected from the group of nortrachelogenin, diasteromeric forms of nortrachelogenin, isomeric forms of nortrachelogenin and combinations thereof as well as 8-methylmatairesinol and 8-methyldimethylmatairesinol, for use in a method of treating cancer or a similar condition wherein the growth factor signaling pathway of a mammal is deregulated. The invention also provides therapeutic pharmaceutical combinations comprising a hydroxy-dibenzylbutyrolactone lignan and at least one TRAIL receptor agonist. The hydroxy-dibenzylbutyrolactone lignans and a TRAIL receptor agonist can be used as a combined preparation for administration to a patient simultaneously, separately or spaced out over a period of time in treating cancer.

  治疗组合物包括至少一种8-取代-二苯基丁内酯木脂素，优选为从北天然黄酮组中选择的木脂素，包括北诺咯杆菌素、北诺咯杆菌素的对映体形式、北诺咯杆菌素的异构体形式和它们的组合，以及8-甲基马泰脂醇和8-甲基二甲基马泰脂醇，用于治疗哺乳动物生长因子信号通路失调引起的癌症或类似疾病的方法。本发明还提供了治疗性药物组合物，包括羟基-二苯基丁内酯木脂素和至少一种TRAIL受体激动剂。羟基-二苯基丁内酯木脂素和TRAIL受体激动剂可以作为联合制剂同时、分别或在一段时间内间隔使用，用于治疗癌症。
• COSMETIC COMPOSITION FOR SKIN WHITENING COMPRISING ARCTIIN, ARCTIGENIN OR THE MIXTURE THEREOF AS ACTIVE
  申请人：Lee Jung Noh

  公开号：US20100104524A1

  公开（公告）日：2010-04-29

  Present Invention relates to a skin whitening cosmetic composition comprising arctiin, arctigenin or a mixture thereof as an active ingredient. The disclosed composition can control or inhibit the synthesis of melanin by acting on a melanin synthesis route of α-MSH secreted by UV, and thus show an excellent whitening effect compared to a conventional skin whitening cosmetic. Also, the composition has high formulation stability and low skin irritation.

  本发明涉及一种皮肤美白化妆品组合物，其包含作为活性成分的牛蒡苷、牛蒡素或两者的混合物。所述组合物可以通过作用于α-MSH分泌的黑色素合成途径来控制或抑制黑色素的合成，因此与传统的皮肤美白化妆品相比，表现出优异的美白效果。此外，该组合物具有高配方稳定性和低皮肤刺激性。
• Stereoselective Synthesis of Methoxy Substituted 2, 3-Dibenzylbutyrolactones Via Organic Phosphonates
  作者：Reinaldo S. Compagnone、Alírica Suárez

  DOI：10.1080/00397919209409252

  日期：1992.11

  A highly convergent, short and stereoselective synthesis of a series of methoxy substituted 2,3-dibenzylbutyrolactones was achieved using a Horner-Wadsworth-Emmons (HWE) reaction as the key step in overall yields above 32%.
• Neelima; Bhaduri, A. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 3, p. 209 - 215
  作者：Neelima、Bhaduri, A. P.

  DOI：——

  日期：——