α-tocopherol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: α-tocopherol
• 英文别名: 5,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-ol
• 化学式: C₂₈H₄₈O₂
• 分子量: 416.688
• InChiKey: WCLCXQXLAQYYQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-mercaptopurine 、 α-tocopherol 以 四氢呋喃 为溶剂， 生成 、 α-tocopheroxy radical
  参考文献：
  名称：

  Photochemical Properties of Excited Triplet State of 6H-Purine-6-thione Investigated by Laser Flash Photolysis

  摘要：

  Photochemical reactions of 6H-purine-6-thione (PuT) via the excited triplet state [(3)(PuT)*] have been studied by means of laser flash photolysis in organic solvents. Transient absorption bands at 475 and 690 nm were assigned to (3)(PuT)*. Intersystem quantum yield and the lowest triplet energy of (3)(PuT)* were evaluated to be 0.99 and 63 kcal/mol, respectively. The self-quenching rate constant is quite large (2.3 x 10(9) M-1 s(-1) in THF). In photoinduced electron transfer, (3)(PuT)* acts as electron acceptor for tetramethylbenzidine, while (3)(PuT)* acts as electron donor for p-dinitrobenzene. Rate constants for H-atom abstraction (k(hT)) Of (3)(PUT)* from benzenethiols, tocopherol, and 1,4-cyclohexadiene are on the order of 10(8) M-1 s(-1). From the Hammett plots of k(hT) for substituted benzenethiols, a negative rho value indicates that (3)(PuT)* has electrophilic character. In the addition reaction of (3)(PuT)* toward various alkenes, the electrophilic character of (3)(PuT)* was also confirmed. By steady-light photolysis of PuT, purine was produced via (3)(PuT)* after H-atom abstraction. On combination of these results, the character of the lowest (3)(PuT)* was presumed.

  DOI：

  10.1021/jp973274q

文献信息

• Method of vitamin production
  申请人：DCV Inc. doing business as Bio-Technical Resourses

  公开号：EP2305825A1

  公开（公告）日：2011-04-06

  The invention relates to methods for producing farnesol or geranylgeraniol comprising: (a) culturing a microorganism in a fermentation medium to produce a product selected from the group consisting of farnesyl phosphate and farnesol or geranylgeranyl phosphate and geranylgeraniol, wherein the action of squalene synthase of said microorganism is reduced; and (b) recovering said product.

  本发明涉及生产法呢醇或香叶基香叶醇的方法，包括：(a) 在发酵培养基中培养微生物，生产选自磷酸法呢醇和法呢醇或磷酸香叶基香叶醇和香叶基香叶醇的产物，其中所述微生物的角鲨烯合成酶的作用减弱；以及 (b) 回收所述产物。