1,4-Dimethyl-1,4-dihydrochinolin | 51483-74-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,4-Dimethyl-1,4-dihydrochinolin
• 英文别名: 1,4-dimethyl-1,4-dihydro-quinoline；1,4 dimethyl quinoline；1,4-dimethyl-4H-quinoline
• CAS: 51483-74-0
• 化学式: C₁₁H₁₃N
• 分子量: 159.231
• InChiKey: PFIYRBCOFBHMQE-UHFFFAOYSA-N

物化性质

• 沸点：
  223.0±33.0 °C(Predicted)
• 密度：
  0.991±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,4-Dimethyl-1,4-dihydrochinolin 、 正丁基锂 、 potassium tert-butylate 、 三甲基氯硅烷 以47%的产率得到
  参考文献：
  名称：

  SCHLOSSER M.; SCHEIDER P., ANGEW. CHEM., 1979, 91, NO 6, 515-517

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-dimethylquinolinium 在 1-苯甲基-1,4-二氢烟酰胺 作用下， 以 水 、 乙腈 为溶剂， 生成 1,4-Dimethyl-1,4-dihydrochinolin
  参考文献：
  名称：

  Bunting, John W.; Fitzgerald, Norman P., Canadian Journal of Chemistry, 1985, vol. 63, p. 655 - 662

  摘要：

  DOI：

文献信息

• Regioreversed Thermal and Photochemical Reduction of 10-Methylacridinium and 1-Methylquinolinium Ions by Organosilanes and Oraganostannanes
  作者：Shunichi Fukuzumi、Morifumi Fujita、Souta Noura、Kei Ohkubo、Tomoyoshi Suenobu、Yasuyuki Araki、Osamu Ito

  DOI：10.1021/jp003518y

  日期：2001.3.1

  (AcrH+) in acetonitrile containing allylic silanes and stannanes results in the efficient and selective reduction of the 10-methylacridinium ion to yield the allylated dihydroacridines. In the photochemical reactions of AcrH+ with unsymmetric allylsilanes, the allylic groups are introduced selectively at the α position. Likewise, the reactions with unsymmetric allylstannanes afforded the α adducts predominantly

  在含有烯丙基硅烷和锡烷的乙腈中辐照 10-甲基吖啶离子 (AcrH+) 的吸收带导致 10-甲基吖啶离子有效且选择性地还原，从而产生烯丙基化二氢吖啶。在 AcrH+ 与不对称烯丙基硅烷的光化学反应中，烯丙基基团选择性地引入到 α 位。同样，与不对称烯丙基锡烷的反应主要得到 α 加合物，但也得到了 γ 加合物作为次要产物。与此相反，不对称烯丙基锡烷对 AcrH+ 和 1-甲基喹啉鎓离子 (QuH+) 的热还原仅产生 γ 加合物。在氟化物阴离子存在下，氢化三丁基锡或氢硅烷对 QuH+ 的热还原也会选择性地产生 1-甲基-1,2-二氢喹啉。
• Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
  申请人：Patton Wayne Forrest

  公开号：US20110130305A1

  公开（公告）日：2011-06-02

  Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.

  提供了染料和组合物，这些染料和组合物在许多应用中非常有用，例如检测和监测蛋白质聚集、蛋白质聚集的动力学研究、神经原纤维样斑块分析、评估蛋白质配方稳定性、蛋白质热稳定性位移测定和分子伴侣活性分析。这些染料和组合物也可作为核酸和蛋白质检测中的探针。
• ASYMMETRIC CYANINE FLUORESCENT DYES
  申请人：Peng Xiaojun

  公开号：US20090017441A1

  公开（公告）日：2009-01-15

  The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R 1 , R 2 , R 3 , R 4 , R 5 and Y − are as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods for staining biological samples using the fluorescent dyes and compositions thereof.

  本公开提供了式I中的不对称青霉素荧光染料，其中X、n、R1、R2、R3、R4、R5和Y-如规范中所定义。本公开还提供了荧光染料的结合物，其制备方法，包含荧光染料的组合物，以及使用荧光染料和其组合物对生物样本进行染色的方法。
• [EN] NOVEL DYES FOR THE DETECTION OR QUANTIFICATION OF DESIRABLE TARGET MOLECULES<br/>[FR] NOUVEAUX COLORANTS POUR LA DÉTECTION OU LA QUANTIFICATION DE MOLÉCULES CIBLES SOUHAITABLES
  申请人：ENZO LIFE SCIENCES INC

  公开号：WO2009014513A1

  公开（公告）日：2009-01-29

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

  本发明提供了染料、反应性染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质和核酸。所提供的染料可在溶液中自由使用，染料与目标分子的结合提供信号生成。还提供了包含反应性基团的染料，可用于将染料连接到将结合到所需目标分子的探针上。本发明的新型染料经过改性以提供有益性能。
• Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
  申请人：Pande Praveen

  公开号：US20090226954A1

  公开（公告）日：2009-09-10

  The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.

  本发明提供染料、反应染料和标记试剂，可用于检测或定量所需的目标分子，如蛋白质、核酸和细胞器。提供了可在溶液中自由使用的染料，其中染料与目标分子的结合提供信号产生。还提供了包含反应基团的染料，可用于将染料附着到将结合到所需目标分子的探针上。本发明的新型染料已被改性以提供有益的性质。