2-(4-acetylphenyl)-4,5-dihydrooxazole | 175979-88-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-acetylphenyl)-4,5-dihydrooxazole
• 英文别名: 2-(p-acetylphenyl)oxazoline；1-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]-1-ethanone；1-[4-(4,5-Dihydro-1,3-oxazol-2-yl)phenyl]ethanone
• CAS: 175979-88-1
• 化学式: C₁₁H₁₁NO₂
• 分子量: 189.214
• InChiKey: DIRXRHYASCZSJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-acetylphenyl)-4,5-dihydrooxazole 在 三甲基溴硅烷 、 三乙胺 、 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 、 四氢呋喃 为溶剂， 反应 23.0h， 生成 2-bromo-1-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]-1-ethanone
  参考文献：
  名称：

  DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION

  摘要：

  公开号：

  EP1956013B1
• 作为产物：
  描述：

  1-[4-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]-1-ethanol 在 manganese(IV) oxide 作用下， 以 氯仿 为溶剂， 反应 5.0h， 生成 2-(4-acetylphenyl)-4,5-dihydrooxazole
  参考文献：
  名称：

  DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION

  摘要：

  公开号：

  EP1956013B1

文献信息

• A General and Efficient Palladium-Catalyzed Carbonylative Synthesis of 2-Aryloxazolines and 2-Aryloxazines from Aryl Bromides
  作者：Xiao-Feng Wu、Helfried Neumann、Stephan Neumann、Matthias Beller

  DOI：10.1002/chem.201202652

  日期：2012.10.22

  Oxazoline is OK! A general and efficient method for the synthesis of oxazolines has been developed (see scheme). This allowed the preparation of 27 five‐membered‐ring heterocycles and 11 six‐membered‐ring heterocycles in moderate to good yields.

  恶唑啉还可以！已经开发了一种合成恶唑啉的通用有效方法（参见方案）。这允许以中等至良好的产率制备27个五元环杂环和11个六元环杂环。
• Ruthenium(II) 8-quinolinolates: Synthesis, characterization, crystal structure and catalysis in the synthesis of 2-oxazolines
  作者：P. Anitha、R. Manikandan、G. Prakash、B. Pachiyappan、P. Viswanathamurthi、J.G. Malecki

  DOI：10.1016/j.jorganchem.2015.06.005

  日期：2015.8

  New octahedral ruthenium(II) complexes (1-4) have been synthesized from the reaction of ruthenium( II) precursors [RuHCl(CO)(EPh3)(3)] (E - P or As) with the bidentate Schiff base ligands, 2-((2,6-dimethylphenylimino) methyl) quinolin-8-ol (L-1) and 2-((2,6-diisopropylphenylimino) methyl) quinolin-8-ol (L-2) in ethanol. These complexes have been characterized by elemental analyses, IR, UV-Vis, H-1, C-13 and P-31 NMR and ESI-Mass spectroscopy. The molecular structure of the complex [RuCl(CO)(PPh3)(2)(L-2)] (2) was determined by single-crystal X-ray diffraction, which reveals a distorted octahedral geometry around ruthenium(II) ion. The catalytic activity of the new complexes was evaluated for the condensation of nitriles with ethanolamine under solvent free conditions. The processes were operative with aromatic and heteroaromatic nitriles and tolerated several substitutional groups. The studies on the effect of substitution over ligands, coligands, reaction time, temperature and catalyst loading were carried out in order to find the best catalyst in this series of complexes and favorable reaction conditions. A probable mechanism for the catalytic condensation of nitrile has also been proposed. The catalyst was recovered and recycled up to five times without significant loss of its activity. (C) 2015 Elsevier B.V. All rights reserved.
• One-Step Conversion of Aldehydes to Oxazolines and 5,6-Dihydro-4<i>H</i>-1,3-oxazines Using 1,2- and 1,3-Azido Alcohols
  作者：Jennifer G. Badiang、Jeffrey Aubé

  DOI：10.1021/jo9521256

  日期：1996.1.1

  The reactions of 1,2- and 1,3-hydroxy azides with aldehydes under acidic conditions were examined. A variety of Lewis acids were examined, of which BF3 . OEt(2) was found the most convenient. Trimethylsilyl ether derivatives of the alcohols could also be reacted using trimethylsilyl triflate as the promoter. Twenty-five examples that proceed in moderate to quantitative yields are reported.
• US8022075B2
  申请人：——

  公开号：US8022075B2

  公开（公告）日：2011-09-20
• DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION
  申请人：Fujifilm RI Pharma Co., Ltd.

  公开号：EP1956013B1

  公开（公告）日：2016-04-13