(S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid | 14296-92-5

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 脯氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid
• 英文别名: Boc-Gly-Pro-OH；(tert-butoxycarbonyl)glycyl-L-proline；Boc-Gly-Pro；Boc-GP-OH；Boc-glycyl-L-proline；N-(tert-butoxycarbonyl)glycyl-L-proline；N-Boc-glycyl-L-proline；(2S)-1-[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]pyrrolidine-2-carboxylic acid
• CAS: 14296-92-5
• 化学式: C₁₂H₂₀N₂O₅
• mdl: MFCD00057234
• 分子量: 272.301
• InChiKey: CMSBRKBRYYDCFQ-QMMMGPOBSA-N

物化性质

• 熔点：
  142-144℃
• 沸点：
  490.9±40.0 °C(Predicted)
• 密度：
  1.248

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  -15°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Boc-Gly-Pro-OH
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Boc-Gly-Pro-OH
CAS number: 14296-92-5

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H20N2O5
Molecular weight: 272.3

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

Boc-Gly-Pro OH是一种甘氨酸（HY-Y0966）的衍生物。

反应信息

• 作为反应物：
  描述：

  (S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid 在 palladium on activated charcoal 甲酸 、 氢气 、 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 、 三乙胺 、 柠檬酸 作用下， 以 甲醇 为溶剂， 反应 89.75h， 生成 N-Boc-S-trityl-L-cysteinyl-glycyl-L-prolyl-glycyl-L-prolyl-S-trityl-L-cysteine benzhydryl ester
  参考文献：
  名称：

  Phenceptin: a biomimetic model of the phenytoin receptor

  摘要：

  5,5-二苯基肼（苯妥英）是最广泛使用的抗癫痫药物，但具有许多副作用。尽管其化学作用方式尚不清楚，但人们认为苯妥英主要通过干扰神经元膜上钠离子的传输来发挥作用。结构活性和亲脂性活性研究表明，该药物通过氢键与N3—C4酰胺键以及与C5取代基的芳香-芳香相互作用与其受体相互作用。由于钠通道是富含半胱氨酸的肽，其功能取决于半胱氨酸[公式：见文本]半胱氨酸氧化还原过程，有人假设苯妥英受体的作用可能被一个设计良好的环脱氨肽所模拟，其中包含一个半胱氨酸基团、一个以三角双锥方式定向排列的五个氧原子构成的腔，适合选择性地传输钠离子，并且有一个结合苯妥英的位点。开发了一个计算程序和策略，允许在合成之前查看潜在靶分子的三维结构。使用该程序导致发现了Boc-L-半胱氨酰基-L-甘氨酰-L-脯氨酰基-L-甘氨酰-L-脯氨酰-L-半胱氨酸-OCHPh₂。这种化合物被称为苯塞普汀，它是从一个线性前体合成的，该前体在N-末端具有叔丁氧羰保护基，在C-末端具有苄基酯保护基，在硫上具有三苄基保护基。用碘在甲醇-吡啶中进行去三苄基化和环化制备苯塞普汀。使用正辛醇膜研究离子传输动力学，发现苯塞普汀只在其氧化的环状形式中选择性地传输钠离子。这种传输受到苯妥英一个当量的显著抑制，而对于该药物的生物非活性类似物则完全没有抑制作用。通过核磁共振在n-C₈D₁₇-OH溶剂中研究苯妥英与苯塞普汀的结合性质，发现药物与一个氧原子参与与钠离子络合的甘氨酸残基之间的氢键结合。

  DOI：

  10.1139/v88-425
• 作为产物：
  描述：

  L-脯氨酸甲酯 在 N-甲基吗啉 、 水 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 乙酸乙酯 为溶剂， 反应 16.0h， 生成 (S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid
  参考文献：
  名称：

  A macrocyclic coumarin-containing tripeptide via CuAAC chemistry

  摘要：

  进行了一项铜催化的环化反应，以获得一种含有香豆素的环状三肽，用于凝血酶活性测定。

  DOI：

  10.1039/b906762k

文献信息

• High penetration prodrug compositions of peptides and peptide-related compounds
  申请人：Yu Chongxi

  公开号：US09248109B2

  公开（公告）日：2016-02-02

  The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of peptides and peptide-related compounds, which are capable of crossing biological barriers with higher penetration efficiency comparing to their parent drugs. The HPPs are capable of being converted to parent drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs/HPCs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs/HPCs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

  这项发明提供了一种新型高渗透性肽类化合物（HPC）或高渗透性前药（HPP）的组合物，这些化合物能够比其原始药物更高效地穿越生物屏障。HPP能够在穿越生物屏障后转化为原始药物或药物代谢物，从而可以治疗原始药物或代谢物所能治疗的疾病。此外，HPP/HPC能够到达原始药物可能无法进入或在目标区域提供足够浓度的区域，从而提供新颖的治疗方法。HPP/HPC可以通过各种给药途径给予受试者，例如，局部给药到疾病作用部位以高浓度给药，或者系统给药到生物体内并以更快的速率进入全身循环。
• Visible‐Light‐Mediated S−H Bond Insertion Reactions of Diazoalkanes with Cysteine Residues in Batch and Flow
  作者：Long‐Zhou Qin、Xin Yuan、Yu‐Sheng Cui、Qi Sun、Xiu Duan、Kai‐Qiang Zhuang、Lin Chen、Jiang‐Kai Qiu、Kai Guo

  DOI：10.1002/adsc.202000716

  日期：2020.11.18

  diazoacetates with cysteine residues that enabled metal‐free, S−H functionalization under visible‐light conditions. Moreover, this process could be intensified by a continuous‐flow photomicroreactor on the acceleration of the reaction (6.5 min residence time). The batch and flow protocols described were applied to obtain a wide range of functionalized cysteine derivatives and cysteine‐containing dipeptides

  我们描述了芳基重氮乙酸酯与半胱氨酸残基的S-H键插入反应的应用，该反应可在可见光条件下实现无金属的S-H功能化。此外，连续反应光微反应器可加快反应速度（6.5分钟的停留时间），从而增强该过程。所描述的批次和流程方案可用于获得各种功能化的半胱氨酸衍生物和含半胱氨酸的二肽，从而为其在温和条件下的功能化提供了一个简单而通用的平台。
• Continuous-flow processes for the <i>S</i>-alkynylation of cysteine-containing peptides and thioglycosides under catalyst-free, oxidant-free and mild conditions
  作者：Long-Zhou Qin、Xin Yuan、Jie Liu、Meng-Yu Wu、Qi Sun、Xiu Duan、Xin-Peng Zhang、Jiang-Kai Qiu、Kai Guo

  DOI：10.1039/d1gc01937f

  日期：——

  Selective S-alkynylation of cysteine-containing peptides and 1-thioglycoside residues was developed using continuous flow.

  含半胱氨酸肽和1-硫代糖苷残基的选择性S-炔基化反应已经在连续流条件下开发。
• Visible-Light-Driven, Copper-Catalyzed Decarboxylative C(sp³ )−H Alkylation of Glycine and Peptides
  作者：Chao Wang、Mengzhun Guo、Rupeng Qi、Qinyu Shang、Qiang Liu、Shan Wang、Long Zhao、Rui Wang、Zhaoqing Xu

  DOI：10.1002/anie.201809400

  日期：2018.11.26

  well‐developed and growing body of work in Cu catalysis, the potential of Cu to serve as a photocatalyst remains underexplored. Reported herein is the first example of visible‐light‐induced Cu‐catalyzed decarboxylative C(sp3)−H alkylation of glycine for preparing α‐alkylated unnatural α‐amino acids. It merits mentioning that the mild conditions and the good functional‐group tolerance allow the modification

  尽管铜催化方面的工作已经发展成熟并且在不断发展，但是铜作为光催化剂的潜力仍未得到开发。本文报道的是第一个可见光诱导的铜催化甘氨酸脱羧C（sp 3）-H烷基化制备甘氨酸α-烷基化非天然α-氨基酸的例子。值得一提的是，温和的条件和良好的官能团耐受性允许使用此方法对肽进行修饰。机理研究表明，该反应涉及自由基-自由基偶联途径。
• [EN] STAT DEGRADERS AND USES THEREOF<br/>[FR] AGENTS DE DÉGRADATION DE STAT ET LEURS UTILISATIONS
  申请人：KYMERA THERAPEUTICS INC

  公开号：WO2021188696A1

  公开（公告）日：2021-09-23

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用相同的方法。