sulphurenic acid | 1260-08-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: sulphurenic acid
• 英文别名: sulfurenic acid；(3β,15α)-dihydroxy-24-methylenelanost-8-en-21-oic acid；(2R)-2-[(3S,5R,10S,13R,14R,15S,17R)-3,15-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid
• CAS: 1260-08-8
• 化学式: C₃₁H₅₀O₄
• 分子量: 486.736
• InChiKey: XZEKQUYJGSOILA-JBDXZHTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  versisponic acid D 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以8 mg的产率得到sulphurenic acid
  参考文献：
  名称：

  Five Lanostane Triterpenoids and Three Saponins from the Fruit Body of Laetiporus versisporus.

  摘要：

  Five lanostane triterpenes, named versisponic acids A-E and three lanostanoid glycosides, laetiposides E-G, were isolated from the fruit bodies of Laetiporus versisporus. Their stuctures were established by extensive NMR experiments and chemical methods.

  DOI：

  10.1248/cpb.48.1418

文献信息

• TRITERPENOID COMPOSITION OF ANTRODIA CINNAMOMEA, PREPARATION AND ANALYSIS METHOD THEREOF
  申请人：WU YANG-CHANG

  公开号：US20120190871A1

  公开（公告）日：2012-07-26

  Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia cinnamomea using HPLC and NMR, as well as the stereo structures and the amounts of the triterpenoid compositions. The cytotoxicity of triterpenoids is also revealed. Based on the aforementioned techniques, the presence and amounts of ergostane and lanostane in the drugs, healthcare food or other goods are able to be detected.

  本发明揭示了采用HPLC和NMR技术从红树孔菌子实体中分离、纯化和分析三萜类化合物（包括麦角甾烷和榄香甾烷），以及三萜类化合物的立体结构和含量。此外，还揭示了三萜类化合物的细胞毒性。基于上述技术，能够检测到药物、保健食品或其他商品中麦角甾烷和榄香甾烷的存在和含量。
• METHOD FOR TREATING STROKE OR REDUCING NERVE INJURY
  申请人：Arjil Biotech Holding Company Limited

  公开号：EP3415145A2

  公开（公告）日：2018-12-19

  The disclosure is related to a compound for use in treating stroke or reducing nerve injury, wherein the compound is isolated and purified from Antrodia camphorata fruiting body by methanol extraction. In particular, the compound is dehydroeburicoic acid, dehydrosulphurenic acid (dehydrosulfurenic acid) or 4,7-Dimethoxy-5-methyl-1,3-benzodioxole.

  本公开涉及一种用于治疗中风或减轻神经损伤的化合物，其中该化合物是通过甲醇萃取从樟芝子实体中分离纯化的。特别是，该化合物是脱氢琥珀酸、脱氢硫琥珀酸或 4,7-二甲氧基-5-甲基-1,3-苯并二恶茂。
• Method and composition for inhibiting virus infection
  申请人：ARJIL BIOTECH HOLDING COMPANY LIMITED

  公开号：US11253527B2

  公开（公告）日：2022-02-22

  The present invention pertains to a composition for preparing a medicament for preventing and/or treating a virus infection, especially a hepatitis B virus infection and/or a herpes simplex virus, and uses thereof.

  本发明涉及一种用于制备预防和/或治疗病毒感染（尤其是乙型肝炎病毒感染和/或单纯疱疹病毒感染）的药物组合物及其用途。
• ANTIVIRAL ACTIVITY FROM MEDICINAL MUSHROOMS AND THEIR ACTIVE CONSTITUENTS
  申请人：Stamets, Paul Edward

  公开号：EP3277271A1

  公开（公告）日：2018-02-07
• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.