Geraniol chloroformate | 15859-43-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Geraniol chloroformate
• 英文别名: geranyl chloroformate；Chlorameisensaeuregeranylester；[(2E)-3,7-dimethylocta-2,6-dienyl] carbonochloridate
• CAS: 15859-43-5
• 化学式: C₁₁H₁₇ClO₂
• 分子量: 216.708
• InChiKey: VTFAPDMMOXFESG-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Geraniol chloroformate 、 2-mercaptopyridine-1-oxide sodium salt 以76%的产率得到2-[(2E)-3,7-dimethylocta-2,6-dienyl]sulfanyl-1-oxidopyridin-1-ium
  参考文献：
  名称：

  Cyclizations and intermolecular additions of alkoxycarbonyloxy radicals from N-hydroxypyridine-2-thione carbonates

  摘要：

  Alkoxycarbonyloxy radicals from allyl and homoallyl alcohols cyclize in an exo fashion to give, respectively, 3-substituted 1,2-diol carbonates and 4-substituted 1,3-diol carbonates whereas simple alkoxycarbonyloxy radicals add intermolecularly to ethyl vinyl ether to give, ultimately, carbonates of glycolaldehyde derivatives.

  DOI：

  10.1016/s0040-4039(00)71214-7
• 作为产物：
  描述：

  光气 、 香叶醇 生成 Geraniol chloroformate
  参考文献：
  名称：

  Cyclizations and intermolecular additions of alkoxycarbonyloxy radicals from N-hydroxypyridine-2-thione carbonates

  摘要：

  Alkoxycarbonyloxy radicals from allyl and homoallyl alcohols cyclize in an exo fashion to give, respectively, 3-substituted 1,2-diol carbonates and 4-substituted 1,3-diol carbonates whereas simple alkoxycarbonyloxy radicals add intermolecularly to ethyl vinyl ether to give, ultimately, carbonates of glycolaldehyde derivatives.

  DOI：

  10.1016/s0040-4039(00)71214-7

文献信息

• FAT EMULSION
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0510197A1

  公开（公告）日：1992-10-28

  A fat emulsion mainly comprising 0.001 to 10 % (w/v) of a mitomycin C derivative of general formula (I), 0.5 to 30 % (w/v) of a simple lipid, a phospholipid in an amount of 0.05 to 2 times by weight as large as the simple lipid, and an appropriate amount of water: (I) wherein X represents -(CH₂)n-O- or -(CH₂)n-NHCOO-; n represents an integer of 0 to 4; and R represents a linear or branched, open-chain or cyclic, saturated or unsaturated hydrocarbon group containing 3 to 25 carbon atomes. This emulsion causes efficient migration of a prodrug of mitomycin C with a carcinostatic action in the form of an injection into the tissues, helps to maintain its blood level, and allows safe administration of an effective dose.

  一种脂肪乳剂，主要包括 0.001-10%(重量/体积)的通式(I)丝裂霉素 C 衍生物、0.5-30%(重量/体积)的单纯脂质、用量为单纯脂质的 0.(I) 其中 X 代表-(CH₂)n-O-或-(CH₂)n-NHCOO-；n 代表 0 至 4 的整数；R 代表含有 3 至 25 个碳原子的线性或支链、开链或环状、饱和或不饱和烃基。这种乳剂能使具有致癌作用的丝裂霉素 C 原药以注射形式有效地迁移到组织中，有助于维持其血液水平，并能安全地施用有效剂量。
• 一种甲基环戊烯醇酮香叶醇碳酸酯香料及其合成方法与应用
  申请人：安徽中烟工业有限责任公司

  公开号：CN114380693A

  公开（公告）日：2022-04-22

  本发明公开了一种甲基环戊烯醇酮香叶醇碳酸酯香料及其合成方法与应用，其化学结构式为： 本发明的新型香料化学结构稳定、香气保持较好，具有焦甜香、花香、蜜甜香香韵，适用于烟用香精、洗涤用品、烘焙食品等产品中产生香气。
• Effect of acyclic monoterpene alcohols and their derivatives on TRP channels
  作者：Giorgio Ortar、Aniello Schiano Moriello、Enrico Morera、Marianna Nalli、Vincenzo Di Marzo、Luciano De Petrocellis

  DOI：10.1016/j.bmcl.2014.10.012

  日期：2014.12

  A series of thirty-six geraniol, nerol, citronellol, geranylamine, and nerylamine derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels. Most of them acted as strong modulators of TRPA1 channels with EC50 and/or IC50 values <1 mu M. None was able to significantly activate TRPM8 channels, while thirteen of them behaved as 'true' TRPM8 antagonists. Little or no effect was generally observed on TRPV1 channels. Some of the compounds examined, that is, compounds 1d, g, n, 2c, d, h, i, o, 3b, e exhibited an appreciable selectivity for TRPA1 subtype. (C) 2014 Elsevier Ltd. All rights reserved.
• Bestmann,H.J.; Schnabel,K.H., Justus Liebigs Annalen der Chemie, 1966, vol. 698, p. 106 - 108
  作者：Bestmann,H.J.、Schnabel,K.H.

  DOI：——

  日期：——
• US5651991A
  申请人：——

  公开号：US5651991A

  公开（公告）日：1997-07-29