N-methyl-O-[3-(perfluorooctyl)propyl]-N-(β-D-glucopyranosyl)hydroxylamine | 1011478-19-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-methyl-O-[3-(perfluorooctyl)propyl]-N-(β-D-glucopyranosyl)hydroxylamine
• 英文别名: (2R,3R,4S,5S,6R)-2-[4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecoxy(methyl)amino]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 1011478-19-5
• 化学式: C₁₈H₂₀F₁₇NO₆
• 分子量: 669.333
• InChiKey: SNQVWSHZJLVRGE-HOTMZDKISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  103
• 氢给体数：
  4
• 氢受体数：
  24

反应信息

• 作为产物：
  描述：

  葡萄糖 、 N-methyl-3-(perfluorooctyl)propylhydroxylamine 在 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以92%的产率得到N-methyl-O-[3-(perfluorooctyl)propyl]-N-(β-D-glucopyranosyl)hydroxylamine
  参考文献：
  名称：

  Synthesis of Fluorous Tags for Incorporation of Reducing Sugars into a Quantitative Microarray Platform

  摘要：

  Carbohydrate microarrays can map out key interactions of carbohydrates and proteins in a high-throughput manner, but require the inclusion of a range of sugars for their optimal use. Here we present the synthesis and use of a new hydroxylamine-modified fluorous tag that allows the facile incorporation of reducing sugars into a noncovalent fluorous-based microarray after simple purification by fluorous solid-phase extraction (FSPE). The microarray supports quantitative screening against carbohydrate-binding proteins.

  DOI：

  10.1021/ol702915e

文献信息

• Synthesis of Fluorous Tags for Incorporation of Reducing Sugars into a Quantitative Microarray Platform
  作者：Guo-Song Chen、Nicola L. Pohl

  DOI：10.1021/ol702915e

  日期：2008.3.1

  Carbohydrate microarrays can map out key interactions of carbohydrates and proteins in a high-throughput manner, but require the inclusion of a range of sugars for their optimal use. Here we present the synthesis and use of a new hydroxylamine-modified fluorous tag that allows the facile incorporation of reducing sugars into a noncovalent fluorous-based microarray after simple purification by fluorous solid-phase extraction (FSPE). The microarray supports quantitative screening against carbohydrate-binding proteins.