N-p-Tolyl-D-xylosylamin | 3054-60-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-p-Tolyl-D-xylosylamin
• 英文别名: p-Toluidino-N-D-xylosid；N-p-Methylphenyl-D-xylosylamine；(3R,4S,5R)-2-(4-methylanilino)oxane-3,4,5-triol
• CAS: 3054-60-2
• 化学式: C₁₂H₁₇NO₄
• 分子量: 239.271
• InChiKey: OUQMOMTTXCJVRM-FBTJUVTCSA-N

物化性质

• 熔点：
  124-125 °C
• 沸点：
  456.7±45.0 °C(Predicted)
• 密度：
  1.410±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  82
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-p-Tolyl-D-xylosylamin 、 乙酸酐 在 吡啶 作用下， 反应 2.0h， 生成 Acetic acid (3R,4S,5R)-4,5-diacetoxy-2-p-tolylamino-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Electron impact mass spectra of per-O-acetyl derivatives of 4′-substituted glycopyranosylphenylamines

  摘要：

  DOI：

  10.1016/0008-6215(88)80073-9
• 作为产物：
  描述：

  D-吡喃木糖 、 乙烷,三氯氟- 在 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 以13%的产率得到N-p-Tolyl-D-xylosylamin
  参考文献：
  名称：

  Synthesis of N-(substituted phenyl)-D-xylopyranosylamines as potential modifiers of the formation of glycosaminoglycans

  摘要：

  N-(Substituted-phenyl)-D-xylopyranosylamines and their O-peracetyl derivatives have been synthesized and tested for their ability (a) to inhibit the replication of cultured B16 melanoma cells and (b) to modify the synthesis of glycosaminoglycans by these neoplastic cells. The most cytotoxic compound synthesized was N-(p-methoxyphenyl)-D-xylopyranosylamine (6), which produced 50% inhibition of cellular proliferation at a concentration of 2 microM; a number of other compounds were relatively cytotoxic, causing 50% inhibition of cell replication at levels of 12 to 25 microM. Several of the synthesized xylosides appeared to be capable of serving as artificial initiators of glycosaminoglycan synthesis, with the most active agents causing approximately 2- to 4-fold increases in the incorporation of [35S]sulfate into the glycosaminoglycans of B16 melanoma cells excreted into the culture medium.

  DOI：

  10.1021/jm00359a002

文献信息

• Synthesis of N-(substituted phenyl)-D-xylopyranosylamines as potential modifiers of the formation of glycosaminoglycans
  作者：Lin Wang、Charles A. Maniglia、Sharon L. Mella、Alan C. Sartorelli

  DOI：10.1021/jm00359a002

  日期：1983.5

  N-(Substituted-phenyl)-D-xylopyranosylamines and their O-peracetyl derivatives have been synthesized and tested for their ability (a) to inhibit the replication of cultured B16 melanoma cells and (b) to modify the synthesis of glycosaminoglycans by these neoplastic cells. The most cytotoxic compound synthesized was N-(p-methoxyphenyl)-D-xylopyranosylamine (6), which produced 50% inhibition of cellular proliferation at a concentration of 2 microM; a number of other compounds were relatively cytotoxic, causing 50% inhibition of cell replication at levels of 12 to 25 microM. Several of the synthesized xylosides appeared to be capable of serving as artificial initiators of glycosaminoglycan synthesis, with the most active agents causing approximately 2- to 4-fold increases in the incorporation of [35S]sulfate into the glycosaminoglycans of B16 melanoma cells excreted into the culture medium.
• Electron impact mass spectra of per-O-acetyl derivatives of 4′-substituted glycopyranosylphenylamines
  作者：J.A. Cremata、A.J. Nún̄ez、E. Díaz、R. León、L.M. Alfonso

  DOI：10.1016/0008-6215(88)80073-9

  日期：1988.9