dibenzyl L-glutamate | 2768-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dibenzyl L-glutamate
• 英文别名: L-glutamic acid dibenzyl ester；glutamic acid dibenzyl ester；dibenzyl glutamate；Glu(OBzl)-OBzl；(S)-dibenzyl 2-aminopentanedioate；H-Glu(OBn)2；dibenzyl (2S)-2-aminopentanedioate
• CAS: 2768-50-5
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.38
• InChiKey: DHQUQYYPAWHGAR-KRWDZBQOSA-N

物化性质

• 沸点：
  453.5±40.0 °C(Predicted)
• 密度：
  1.183±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  dibenzyl L-glutamate 在 1,4-二氧六环 、 三正丁胺 、 氢碘酸 、 氯甲酸乙酯 、 potassium carbonate 、 钯 、 溶剂黄146 作用下， 生成 N-L-γ-glutamyl-D-alanine
  参考文献：
  名称：

  Optical Rotation of Peptides. VII. α- and γ- Dipeptides of Glutamic Acid and Alanine¹

  摘要：

  DOI：

  10.1021/ja01114a528
• 作为产物：
  描述：

  N-苄氧羰基-L-谷氨酸 在 氢溴酸 、 对甲苯磺酸 、 溶剂黄146 、 甲苯 作用下， 生成 dibenzyl L-glutamate
  参考文献：
  名称：

  Helferich et al., Chemische Berichte, 1957, vol. 90, p. 700,707

  摘要：

  DOI：

文献信息

• NOVEL NITROGEN-CONTAINING COMPOUND OR SALT THEREOF, OR METAL COMPLEX THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20160199520A1

  公开（公告）日：2016-07-14

  The present invention provides a compound represented by the formula (1) or a salt thereof, or a complex of the compound or the salt with a metal, in the formula (1), A 1 represents a chelate group; R 1 represents a hydrogen atom or the like; R 2 represents a hydrogen atom or the like; and Z 1 , Z 2 , Z 3 , Z 4 , and Z 5 are the same or different and each represent a nitrogen atom or CR 3 or the like wherein R 3 represents a hydrogen atom or an optionally substituted C 1-6 alkyl group or the like; L 1 represents a group represented by the formula (3) wherein R 13 , R 14 , R 15 , and R 16 are the same or different and each represent a hydrogen atom or the like; L 2 represents an optionally substituted C 1-6 alkylene group; and L 3 represents an optionally substituted C 1-6 alkylene group.

  本发明提供了由式（1）表示的化合物或其盐，或者该化合物或盐与金属形成的络合物，其中在式（1）中，A1代表螯合基团；R1代表氢原子或类似物；R2代表氢原子或类似物；Z1、Z2、Z3、Z4和Z5相同或不同，每个代表氮原子或CR3或类似物，其中R3代表氢原子或可选择取代的C1-6烷基基团或类似物；L1代表由式（3）表示的基团，其中R13、R14、R15和R16相同或不同，每个代表氢原子或类似物；L2代表可选择取代的C1-6亚烷基基团；L3代表可选择取代的C1-6亚烷基基团。
• SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDES
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20130244958A1

  公开（公告）日：2013-09-19

  There are provided compounds of the formula wherein X, Y, Z, R 1 , R 2 , R 3 and R 4 are as described herein and enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

  提供了以下式的化合物 其中X、Y、Z、R1、R2、R3和R4如本文所述 以及其对映体和药用可接受的盐和酯。这些化合物可用作抗癌药物。
• N-substituted prodrugs of fluorooxindoles
  申请人：Starrett E. John

  公开号：US20050203089A1

  公开（公告）日：2005-09-15

  The present invention provides novel N-substituted fluorooxindoles having the general Formula I wherein the wavy bond represents the racemate, the (R)-enantiomer or the (S)-enantiomer and m, n, p, q, A, B, D, Q, X, and Z are as defined below, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of potassium channels.

  本发明提供了具有一般式I的新型N-取代氟代草酮，其中波浪键代表消旋体，(R)-对映体或(S)-对映体，m、n、p、q、A、B、D、Q、X和Z如下所定义，或其无毒的药学上可接受的盐或溶剂，用于治疗对钾通道开放有响应的疾病。
• Flies and flowers: taxonomic diversity of anthophiles and pollinators
  作者：B.M.H. Larson、P.G. Kevan、D.W. Inouye

  DOI：10.4039/ent133439-4

  日期：2001.8

  The Diptera are the second most important order among flower-visiting (anthophilous) and flower-pollinating insects worldwide. Their taxonomic diversity ranges from Nematocera to Brachycera, including most families within the suborders. Especially important are Syrphidae, Bombyliidae, and Muscoidea. Other families, especially of small flies, are less appreciated and often overlooked for their associations with flowers. We have compiled records of their flower visitations to show that they may be more prevalent than usually thought. Our knowledge of anthophilous Diptera needs to be enhanced by future research concerning (i) the significance of nocturnal Nematocera and acalypterate muscoids as pollinators, (ii) the extent to which the relatively ineffective pollen-carrying ability of some taxa can be compensated by the abundance of individuals, and (iii) the role of Diptera as pollinators of the first flowering plants (Angiospermae) by using phylogenetic and palaeontological evidence. Specializations in floral relationships involve the morphology of Diptera, especially of their mouthparts, nutritional requirements, and behaviour, as well as concomitant floral attributes. The South African flora has the most highly specialized relations with dipterous pollinators, but in arctic and alpine generalist fly–flower relations are important in pollination and fly nutrition.

  摘要双翅目昆虫是全世界访花（嗜蚁）昆虫和授粉昆虫中第二重要的目。双翅目昆虫在分类学上具有多样性，从线虫纲（Nematocera）到臂翅目（Brachycera），包括亚目中的大多数科。其中尤为重要的是蚜蝇科（Syrphidae）、蝇科（Bombyliidae）和麝科（Muscoidea）。其他科，尤其是小型苍蝇科，与花卉的关系较少受到重视，也经常被忽视。我们汇编了它们的访花记录，以显示它们可能比通常认为的更为普遍。我们对嗜粉双翅目昆虫的了解需要通过未来的研究来加强，这些研究涉及：（i）夜行蝇类（Nematocera）和螨类作为授粉者的重要性；（ii）某些类群相对较弱的花粉携带能力在多大程度上可以通过个体的丰富程度来弥补；以及（iii）通过使用系统发育和古生物学证据来研究双翅目昆虫作为最早开花植物（被子植物）授粉者的作用。花卉关系中的特化涉及双翅目昆虫的形态，尤其是其口器、营养需求和行为，以及相关的花卉属性。南非植物区系与双翅目传粉昆虫的关系最为专业化，但在北极和高山地区，普通苍蝇与花卉的关系在传粉和苍蝇营养方面也很重要。
• [EN] PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASAL INSULIN OF WHICH THE PI IS FROM 5.8 TO 8.5 AND A CO-POLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS AND A LIMITED AMOUNT OF M-CRESOL<br/>[FR] SOLUTION INJECTABLE DE PH 7 COMPRENANT AU MOINS UNE INSULINE BASALE À PI COMPRIS ENTRE 5,8 ET 8,5 ET UN ACIDE CO-POLYAMINO PORTANT DES CHARGES CARBOXYLATE ET DES RADICAUX HYDROPHOBES ET UNE QUANTITÉ LIMITÉE DE M-CRÉSOL
  申请人：ADOCIA

  公开号：WO2020115333A1

  公开（公告）日：2020-06-11

  The invention relates to physically stable compositions in the form of an injectable aqueous solution, the pH of which is from 6.0 to 8.0, comprising at least: a) a basal insulin whose isoelectric point (pI) is from 5.8 to 8.5, b) m-cresol in a concentration lower than or equal to 30 mM (0 < [m-cresol] ≤ 30 mM), and c) a co-polyamino acid bearing carboxylate charges and at least one Formula X hydrophobic radical.

  这项发明涉及一种物理稳定的组合物，其形式为可注射的水溶液，其pH值为6.0至8.0，包括至少：a) 一种碱性胰岛素，其等电点（pI）为5.8至8.5，b) 间甲酚的浓度低于或等于30毫摩尔（0 < [间甲酚] ≤ 30毫摩尔），以及c) 一种带有羧酸基团和至少一个X式疏水基团的共聚氨基酸。